Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women

Yazıcı, Selma; Yazıcı, Mehmet; Korkmaz, Uğur; Erkan, Melih Engin; Baki, Ali Erdem; Erden, İsmail; Özhan, Hakan; Ataoğlu, Safinaz

doi:10.5114/aoms.2011.22077

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…In fact, cross-sectional analyses and prospective studies revealed that 25-hydroxy vitamin D (25-OHD) serum levels were inversely related to high cardiovascular risk [3–5] and calcium metabolism and the cardiovascular system may have an interaction [6]. On the other hand, normalisation of 25-OHD level by exogenous supplementation is associated with a slight but significant improvement in blood pressure [7–10].…”

Section: Introductionmentioning

confidence: 99%

25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women

Ertek¹,

Akgül²,

Cicero³

et al. 2012

aoms

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IntroductionVitamin D was shown to be related to endothelial function and blood pressure. Reactive hyperaemia index (RHI) measurement by pulse arterial tonometry is a new method to evaluate vasodilator function of endothelium. We aimed to evaluate the relationship between vitamin D levels and RHI in women.Material and methodsWe enrolled 56 normotensive, nonsmoker, normolipidemic and normoglycemic women, (23 with 25-OH-vitamin D levels>20 µg/l, and 33 with values lower than 20 µg/l). The cardiologist who was blind for vitamin D results executed measurements by pulse arterial tonometry. The measurement was performed on the lying patient with pre- and post-occlusion measurements of RHI by digital sensors placed on each index finger, by 5 min intervals. Pulse amplitudes were recorded, pre-occlusion and post-occlusion ratio was compared by the software of device. Stepwise linear regression and multiple regression analyses were performed to evaluate predictors of endothelial function.ResultsThe low vitamin D group had a lower RHI value than the normal vitamin D group (p = 0.042). In regression analysis, positive predictors of RHI were serum 25-OHD (β = 0.401; 95% CI 0.010–0.042, p = 0.002), serum albumin (β = 0.315; 95% CI 0.286–2.350, p = 0.013), and, inversely, serum calcium (β = −0.247; 95% CI (−1.347)-(−0.010), p = 0.047).ConclusionsSerum 25-hydroxy vitamin D was significantly related to endothelial functions measured as RHI, even in healthy non-smoker women.

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Section: Introductionmentioning

confidence: 99%

25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women

Ertek¹,

Akgül²,

Cicero³

et al. 2012

aoms

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“…Osteoporosis is a serious health problem in our country, as in many other countries (1). In the diagnosis and followup of osteoporosis, double-energy X-ray absorptiometry (DXA) management is used as the golden standard (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…Osteoporosis (OP) is characterized with a decrease in bone density and increasing bone fragility, spoiling the micro-structure of bone structure, and affects millions of women and men and is a frequently seen, chronic, progressive, and systemic disease (1)(2)(3). Osteoporosis is a serious health problem in our country, as in many other countries (1).…”

Section: Introductionmentioning

confidence: 99%

Assessment of 10-Year Major Osteoporotic and Femur Fracture Risk of Postmenopausal Women Using FRAX®

Demir¹,

Kutlu²,

Çivi³

2014

Turk J Phys Med Rehab

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ÖzetAmaç: Bu çalışmanın amacı, postmenopozal kadınlarda osteoporoz (OP) risk faktörlerini ve Dünya Sağlık Örgütü (DSÖ) kırık risk değerlendirme skalası (FRAX) kullanılarak 10 yıllık majör OP ile kalça kırığı riskini değer-lendirmektir. Gereç ve Yöntemler: Kesitsel tipteki bu analitik araştırma 340 postmenopozal kadında yapıldı. Katılımcıların risk faktörleri ile kemik mineral yoğunluklarını (KMY) göz önünde bulundurarak ve FRAX risk değerlen-dirme skalası kullanılarak 10 yıllık majör osteoporotik ve kalça kırığı riskleri hesaplandı. Bulgular: Çalışmamızda kadınların yaş ortalamaları 57,5±7,8 idi. 8) osteoporotik, 177'si (%52,1) osteopenik, 116'sı (%34,1) normal olarak bulundu. Yaş arttıkça OP sıklığı artarken (p<0,001), beden kitle indeksi (BKİ) arttıkça OP sıklığı azalıyordu (p<0,001). Osteoporoz varlığı göz önüne alındığında, KMY kullanılarak veya kullanılmadan hesaplanan majör osteoporotik ve kalça kırığı riskleri arasında istatistiksel olarak anlamlı derecede önemli bir ilişki vardı (p<0,001). Kemik mineral yoğunlukları kullanılarak hesaplanan majör osteoporotik kırık riski katı-lanların %94,7'sinde düşük, %5'inde orta ve %0,3'ünde yüksek idi. Osteoporoz risk faktörleri incelendiğinde; 2 ve daha az klinik risk faktörü olanlarda OP sıklığı %12,8 iken, 3 veya 4 risk faktörü olanlarda bu sıklık %28,0 idi. Sonuç: Bu çalışmada, 10 yıllık osteoporotik kırık riskini değerlendirmede KMY kullanılsın ya da kullanılmasın FRAX risk değerlendirme skalasının önemli, maliyet etkin ve kullanması kolay bir değerlendirme kriteri olduğu sonucuna varılmıştır. Anahtar Kelimeler: Osteoporoz, postmenopozal kadın, klinik risk faktörleri, FRAX ® Abstract Objective: The aim of this study is to assess osteoporosis (OP) risk factors in postmenopausal women and 10-year major osteoporosis and femur facture risks using the World Health Organization's fracture risk assessment scale (FRAX ® ). Material and Methods:This cross-sectional analytic study was carried out on 340 postmenopausal women. Considering participant risk factors and bone mineral densities and using the FRAX ® risk assessment scale, their 10-year major osteoporotic and femur fracture was assessed. Results: The mean age of the women in our study was 57.5±7.8. Of the participants, 47 (13.8%) were osteoporotic, 177 (52.1%) were osteopenic, and 116 (34.1%) were normal. As age increased, OP frequency increased (p<0.001), and as body mass index (BMI) increased, OP frequency decreased (p<0.001). Considering OP existence, there was a statistically significant relation between major OP risk and femur fracture risk, calculated using BMD and without using BMD (p<0.001). Major OP fracture risk, calculated using BMD, was low in 94.7% of the subjects, mild in 5.0%, and high in 0.3%. When osteoporosis risk factors were assessed, while OP frequency in those with 2 or fewer clinical risk factors (CRFs) was 12.8%, OP frequency was 28.0% in those with 3 or 4 risk factors. Conclusion: In this study, it was determined that the FRAX ® risk assessment scale, which is used to assess 10-year OP fra...

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“…Although in this study there is no relationship was found between blood pressure and bone density, the direction of correlation is negative. Yazici et al (2011) mentioned that hypertension is a predictor of osteopenia and osteoporosis. Other studies suggest that bone mineral content (BMC) in juvenile hypertension is lower than the non-hypertensive teenagers (Pludowski et al 2007).…”

Section: Correlation Between Metabolic Syndrome Components Confoundimentioning

confidence: 99%

Metabolic Syndrome and Bone Density in Obese Adolescents

2019

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The purpose of this study was to analyse the correlations of metabolic syndrome components (central obesity, triglyceride levels, and hypertension) and related factors including nutrient intake and bone physical activity with bone density in obese adolescents. A cross-sectional study was conducted involving 47 obese adolescents (15-18 years) from three high schools in Semarang city, Central Java, selected by consecutive sampling. Bone density was measured by the Quantitative Ultrasound method. Metabolic syndrome and osteopenia were detected in 28% and 11% subjects, respectively. Positive correlations were found between triglyceride levels, calcium intake, vitamin D intake, current bone-physical activity (cBPA) and bone density (p<0.05). Conversely, central obesity, blood pressure, protein intake, animal protein, plant protein, phosphorus, potassium, sodium, past bone-physical activity (pBPA), and total bone-physical activity (tBPA) were not correlated with bone density. It was found that calcium intake, cBPA, and triglyceride levels were the two strongest factors related to bone density (adjusted R 2 =52.5%). This study showed that obese adolescents are at risk of having metabolic syndrome and higher triglyceride levels imply lower bone density.

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Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women

Cited by 32 publications

References 26 publications

25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women

25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women

Assessment of 10-Year Major Osteoporotic and Femur Fracture Risk of Postmenopausal Women Using FRAX®

Metabolic Syndrome and Bone Density in Obese Adolescents

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