Relationship Between Blood Viscosity and No-Reflow Phenomenon in St-Segment Elevation Myocardial Infarction Performed in Primary Percutaneous Coronary Interventions

Yıldırım, Arafat; Küçükosmanoğlu, Mehmet; Koyunsever, Nermin Yıldız; Çekici, Yusuf; BELİBAĞLI, Mehmet Cenk; Kilic, Salih

doi:10.2217/bmm-2020-0772

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…37 HSR and LSR are parameters that are classically formulated from total protein and hematocrit values, which are indicators of serum viscosity and are used in many thrombogenic conditions, including no-reflow. [38][39][40] The MAPH score, which we created by adding age in addition to these parameters that have an effect on viscosity, showed a better performance in showing increased thrombus load in STEMI patients according to both self-forming hematocrit, age, total protein and MPV values, and compared to known biomarkers such as HSR and LSR.…”

Section: Discussionmentioning

confidence: 99%

A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score

Abacıoğlu

Yıldırım

Karadeniz

et al. 2022

Clin Appl Thromb Hemost

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Aim to investigate whether the MAPH score, which is a new score that combines blood viscosity biomarkers such as mean platelet volume (MPV), total protein and hematocrit, can be used to predict thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients. Methods A total of 473 consecutive patients with STEMI were included in the study. Intracoronary tirofiban/abciximab infusion was applied to patients with thrombus load ≥3 and these patients (n = 71) were defined as the patient group with high thrombus load. MPV, age, hematocrit and total protein values of the patients were recorded. High shear rate (HSR) and low shear rate (LSR) were calculated from total protein and hematocrit values. Cut-off values were determined for high thrombus load by using Youden index, and score was determined as 0 or 1 according to cut-offs. The sum of the scores was calculated as the MAPH score. Results The mean age of the patients included in the study was 59.6 ± 12.6 (n = 354 male, 74.8%). There was no difference between the groups in terms of gender, HT and DM ( P = .127, P = .402 and P = .576, respectively). In the group with high thrombus load; total protein, MPV and hematocrit values were higher ( P < .001, P = .001 and P = .03, respectively). Comparison of receiver operating characteristic (ROC) curve analysis revealed that the MAPH score had better performance in predicting higher thrombus load than both other self-containing parameters and HSR and LSR. Conclusion The MAPH score may be a new score that can be used to determine thrombus burden in STEMI patients.

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Section: Discussionmentioning

confidence: 99%

A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score

Abacıoğlu

Yıldırım

Karadeniz

et al. 2022

Clin Appl Thromb Hemost

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“…In addition, the importance of blood viscosity has been revealed in previous studies. High WBV at an HSR and an LSR has been related to poor results for STEMI patients performed PCI with a risen risk for the presence of apical thrombus, stent thrombosis and no reflow [24,25]. Moreover, elevated WBV at both shear rates has been related to an HTB and an independent predictor for an HTB in patients with NSTEMI [14].…”

Section: Discussionmentioning

confidence: 99%

The predictive value of MAPH score for determining thrombus burden in patients with non-ST segment elevation myocardial infarction

et al. 2022

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Background A high thrombus burden has been connected with poor clinical events in patients with non-ST segment elevation myocardial infarction (NSTEMI). In patients with STEMI, a high MAPH score has been associated with a large thrombus burden. However, the predictive value of the MAPH score in determining the thrombus burden in patients with NSTEMI is unclear. The present report aimed to evaluate the prognostic role of the MAPH score in the estimating coronary thrombus burden in NSTEMI patients. The study patients were split into two groups according to their thrombus grade. The low shear rate (LSR) and high shear rate (HSR) were estimated by haematocrit levels and serum total protein levels. The MAPH score was calculated by adding mean platelet volume (MPV) levels and age, in addition to total protein and haematocrit. Results The patients with a high thrombus burden (HTB) had a higher LSR, higher HSR and higher MAPH score compared to patients with low thrombus burden. MAPH score was found to be an independent predictors of HTB in Model 1 (OR: 1.124, 95% CI: 1.011–1.536; p = 0.039) and Model 2 (OR: 1.236; 95% CI: 1.002–1.525; p = 0.047). The cut-off value of the MAPH score for predicting HTB was 2 based on the Youden index. Conclusions The MAPH score, which calculated by adding MPV levels and age, in addition to total protein and haematocrit, is a novel, easily accessible score. The MAPH score at both LSR and HSR was an independent predictor of HTB.

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“…Patients suffering from acute pulmonary embolism and stroke may also experience negative outcomes. [14][15][16][17][18][19] There is currently no research in the literature to assess the effect of WBV on the prognosis in patients with COVID-19 and its relationship with the deterioration in cardiovascular parameters after the patients recover. The aim of this study is to evaluate the effects of WBV on prognosis and deterioration in cardiac parameters after recovery in COVID-19 patients, with cardiac MRI and echocardiography which are sensitive tools in the detection of cardiac involvement in patients with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

May high blood viscosity predict cardiac involvement in COVID-19 patients?

Karataş,

Keles,

Emrecan Parsova

et al. 2024

JCCVS

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Aims: Assessing the effects of whole blood viscosity (WBV) on prognosis and deterioration in cardiac parameters in COVID-19 patients after recovery using cardiac magnetic resonance imaging (CMRI) and echocardiography is the purpose of this study. Methods: The study involved 70 patients. Patients who had COVID-19 pneumonia were admitted to the hospital. All patients met the eligibility criteria if they remained symptom-free of respiratory and cardiac symptoms and had negative swab test results at the end of the isolation period, for at least two weeks following the positive swab test result. Transthoracic echocardiography was performed within 24 hours prior to CMRI. WBV was measured in centipoises (cP) at 208 seconds-1 shear rate. The median value of WBV was calculated for the entire study population, which was subsequently utilized to divide the population into two subgroups. These were designated as high WBV and low WBV subgroups. Results: Elevated levels of hemoglobin, hematocrit, total protein, C-reactive protein, D-dimer, and fibrinogen were observed in individuals with high WBV. Conversely, TAPSE, S, and FAC were notably reduced in those with high WBV. Notably, CMRI revealed significant increases in native T1, native T2 mapping signal, and extracellular volume among patients with high WBV. Furthermore, in individuals with high WBV, there was a significant decrease in right ventricle stroke volume and right ventricle ejection fraction, accompanied by a notable increase in right ventricle end-systolic volume. Conclusion: WBV values measured during hospital admission may have early and late prognostic importance for COVID-19 infection.

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Relationship Between Blood Viscosity and No-Reflow Phenomenon in St-Segment Elevation Myocardial Infarction Performed in Primary Percutaneous Coronary Interventions

Cited by 8 publications

References 29 publications

A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score

A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score

The predictive value of MAPH score for determining thrombus burden in patients with non-ST segment elevation myocardial infarction

May high blood viscosity predict cardiac involvement in COVID-19 patients?

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