Relationship Between BMI and Age at Diagnosis of Type 1 Diabetes in a Mediterranean Area in the Period of 1990–2004

Giménez, Marga; Aguilera, Eva; Castell, Conxa; Lara, Núria; Nicolau, Joana; Conget, Ignacio

doi:10.2337/dc06-2578

Cited by 28 publications

(33 citation statements)

References 15 publications

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“…Increased weight and BMI in children who have developed diabetes have been reported in some studies [18-20, 23, 24], but were not found in others [25][26][27]. The results in some of these studies [23,26,27] are complicated by the use of data collected from patients after diagnosis of diabetes, when insulin therapy had already been introduced.…”

Section: Introductionmentioning

confidence: 98%

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Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes

et al. 2008

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Aims/hypothesis High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). Methods Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. Results Birth length SDS corrected for MPH was increased in children developing diabetes compared with all (p< 0.048) and with non-HLA-(p<0.050) but not with HLAmatched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p<0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. Conclusions/interpretation Birth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA-but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA-and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes.

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Section: Introductionmentioning

confidence: 98%

“…The results in some of these studies [23,26,27] are complicated by the use of data collected from patients after diagnosis of diabetes, when insulin therapy had already been introduced. In the Diabetes Prediction in Skåne (DiPiS) study [14,28,29], children are followed from birth.…”

Section: Introductionmentioning

confidence: 99%

Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes

et al. 2008

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“…In addition a positive association between BMI-SDS and age at diagnosis has been also reported [176].…”

Section: Accelerator Hypothesismentioning

confidence: 81%

“…Noteworthy, other reports don't agree with the primary pathogenic role of obesity [174,175]. Recently another study in a large cohort of patients from the Mediterranean area makes this theory controversial and unproven up to now [176].…”

Section: Accelerator Hypothesismentioning

confidence: 98%

Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Group

d’Annunzio¹,

Accogli²,

Tallone³

et al. 2013

Genes and Autoimmunity - Intracellular Signaling and Microbiome Contribution

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“…Reports from the United Kingdom indicated a relationship between younger age at diagnosis of T1D and higher body mass index (BMI) in Middlesbrough [35], and Plymouth [64],but not in Birmingham [61]. Other European studies of large cohorts of German and Austrian children with T1D supported the hypothesis [62,63], although studies from Spain and Australia [66,67] did not. Two studies have been conducted in the United States to examine this hypothesis.…”

Section: Environmental and Behavioral Factorsmentioning

confidence: 99%

Double Diabetes: The Search for a Treatment Paradigm in Children and Adolescents

Nwosu¹

2013

Hot Topics in Endocrine and Endocrine-Related Diseases

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Relationship Between BMI and Age at Diagnosis of Type 1 Diabetes in a Mediterranean Area in the Period of 1990–2004

Cited by 28 publications

References 15 publications

Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes

Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes

Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Group

Double Diabetes: The Search for a Treatment Paradigm in Children and Adolescents

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