Relationship between body-mass index and serum folate concentrations in pregnant women

Kim, H.; Hwang, Ji Yun; Kim, K. N.; Ha, Eh; Park, Hyesook; Ha, Mina; Lee, K. Y.; Hong, Yun Chul; Tamura, Tsunenobu; Chang, Namsoo

doi:10.1038/ejcn.2011.160

Cited by 25 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An inverse relation between pre-pregnancy BMI and folate, vitamin D, carotenoids has formerly been reported [10,11,13]. Our results have expanded this knowledge by reporting also lower levels of PLP (vitamin B6), riboflavin (vitamin B2), and cobalamin (vitamin B12) with higher pre-pregnancy BMI.…”

Section: Discussionsupporting

confidence: 84%

“…An inverse relation between pre-pregnancy BMI and several micronutrients like folate, vitamin D, carotenoids, zinc, and essential fatty acids have been reported in pregnant women, and negative pregnancy outcomes related to obesity might be related to impaired micronutrient status [10,11,12,13]. An adequate B vitamin status during pregnancy is important for maternal health and normal fetal development [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

et al. 2016

View full text Add to dashboard Cite

Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5′-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5′-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Our data indicate that the differential association between serum and RBC folate and BMI observed in non-pregnant obese women likely persists into pregnancy. Serum folate was also found to be inversely associated with BMI at mid and late pregnancy in Korean women, although no RBC folate was measured simultaneously in that study (14) . In both Canadian and American populations, non-pregnant obese women, including those of childbearing age, have been shown to have lower plasma folate and higher RBC folate in comparison to normal-weight women (2,5,7) .…”

Section: Discussionmentioning

confidence: 99%

Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women

Shen

Chaudhry

MacFarlane

et al. 2016

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women. Design: A cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual. Setting: The Ottawa Hospital and Kingston General Hospital, Ontario, Canada. Subjects: Pregnant women recruited between 12 and 20 weeks of gestation. Results: A total of 869 pregnant women recruited from April 2008 to April 2009 were included in the final analysis. Serum folate was inversely associated and RBC folate positively associated with BMI, after adjusting for folic acid supplementation, age, gestational age at blood sample collection, race, maternal education, annual income, smoking and MTHFR 677C→T genotype. In stratified analyses, this differential association was significant in women with the MTHFR CC variant. In women with the CT and TT variants, the differential associations were in the same direction but not significant. Folic acid supplementation during pregnancy did not alter the differential association of BMI with serum and RBC folate concentration. This indicates that the current RBC folate cut-off approach for assessing risk of neural tube defects in obese women may be limited. Conclusions: BMI is inversely associated with serum folate and positively associated with RBC folate in pregnant women, especially for those with the MTHFR CC variant.

show abstract

“…The negative association between raised pre-pregnancy BMI and folate status did not appear to be related to dietary inadequacy in these women unlike those described by others [ 9 , 10 , 11 ]. It is possible that other adaptations to a high pre-pregnancy BMI, such as hormonal changes in pregnancy and endocrine modifications, could contribute [ 6 ]. It is possible that adaptations within the maternal microbiome could impact on maternal folate status [ 32 ], as has been shown in the rat during late gestation when manipulating macronutrient intake [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Limited dietary availability can contribute to abnormal DNA methylation patterns in mice [ 4 ] and, thus, potentially to developmental programming [ 5 ]. Fortification of the diet with folic acid has been adopted by many countries to ensure that dietary intake is rarely limited, particularly during pregnancy, in order to prevent neural tube defects when folate requirements can increase because of increased rates of cell division and growth, especially during embryo development [ 6 , 7 ]. Indeed, it is now recommended that, during pregnancy, there should be no upper limit on dietary intake [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta

et al. 2018

View full text Add to dashboard Cite

Dietary methyl donors, including folate, may modify the placenta and size at birth but the influence of maternal body weight has not been widely investigated. We therefore examined whether maternal or fetal folate status, together with indices of placental folate transport, were modulated by either maternal pre-pregnancy body mass index (BMI i.e., overweight: 25 ≤ BMI < 30 or obesity: BMI ≥ 30 kg/m2) and/or gestational diabetes mellitus (GD). We utilised a sub-sample of 135 pregnant women participating in the Spanish PREOBE survey for our analysis (i.e., 59 healthy normal weight, 29 overweight, 22 obese and 25 GD). They were blood sampled at 34 weeks gestation, and, at delivery, when a placental sample was taken together with maternal and cord blood. Placental gene expression of folate transporters and DNA methyltransferases (DNMT) were all measured. Folate plasma concentrations were determined with an electro-chemiluminescence immunoassay. Food diaries indicated that folate intake was unaffected by BMI or GD and, although all women maintained normal folate concentrations (i.e., 5–16 ng/mL), higher BMIs were associated with reduced maternal folate concentrations at delivery. Umbilical cord folate was not different, reflecting an increased concentration gradient between the mother and her fetus. Placental mRNA abundance for the folate receptor alpha (FOLR1) was reduced with obesity, whilst DNMT1 was increased with raised BMI, responses that were unaffected by GD. Multi-regression analysis to determine the best predictors for placental FOLR1 indicated that pre-gestational BMI had the greatest influence. In conclusion, the placenta’s capacity to maintain fetal folate supply was not compromised by either obesity or GD.

show abstract

Relationship between body-mass index and serum folate concentrations in pregnant women

Cited by 25 publications

References 11 publications

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women

The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta

Contact Info

Product

Resources

About