Relationship between body mass index and outcomes for patients with oral squamous cell carcinoma

Wang, Chong; Pan, Yuesong; Xu, Qiaoshi; Li, Bo; Kim, Kyojin; Mao, Minghui; Li, Jinzhong; Qin, Lizheng; Li, Hua; Han, Zhengxue; Feng, Zhien

doi:10.1111/odi.12963

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…Preventing a decline in the nutritional status prior to surgery could be a means to reduce these negative consequences. In another study, our team found that the incidence of complications after OSCC surgery was highest (33.3%) in the low BMI group, but no significant relationship between BMI and POCs was demonstrated in this study (14). This may be due to the stricter screening procedure before free flap reconstruction for patients enrolled in this study.…”

Section: Perioperative Factors (Operation Time and Antibiotic Prophyl...contrasting

confidence: 60%

“…Demographic factors (age, sex, Body Mass Index (BMI) and weight loss), tumor anatomy and pathological features (tumor site, T stage, pathological nodal [pN] stage, clinical features, and growth patterns) and operation-related variables (operation time, blood loss, intraoperative fluid, tracheostomy[yes/no], type of flaps used, ND (unilateral/bilateral), type of antibiotic prophylaxis and red blood cell (RBC) transfusion during the operation[yes/no]) were recorded. Based on World Health Organization (WHO) cutoff points of BMI status, BMI were categorized into obese (≥30.0 kg/m 2 ), overweight (25.0-29.9 kg/ m 2 ), normal weight (18.5-24.9 kg/m 2 ), and underweight (<18.5 kg/m 2 ) (14). Weight loss was defined as "weight loss >10% of the body weight within the past 6 months (21).…”

Section: Covariatesmentioning

confidence: 99%

“…Many valuable works had been done about POCs of free-flap reconstruction for head and neck cancers, and reported rates of POCs ranged from 15% to 62% in published studies (10)(11)(12)(13)(14)(15). Most of the literatures are retrospective study based on medical records or public database, while the occurrence and severity of complications were usually not defined or described so clearly (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data

Wang

Wei

et al. 2022

Front. Oncol.

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BackgroundPostoperative complications (POCs) of moderate-advanced head and neck squamous cell carcinoma (HNSCC) after free flap reconstruction have received little attention. We investigated the risk factors that lead to POCs and their impact on management and prognosis.Patients and MethodsA single-center, prospective cohort study was conducted at Beijing Stomatological Hospital on primary HNSCC patients treated between 2015 and 2020.ResultsIn total, 399 consecutive HNSCC patients who underwent radical resection of the primary tumor and free flap reconstruction were enrolled in this study, 155(38.8%) experienced POCs. The occurrence of POCs directly led to worse short-term outcomes and poorer long-term overall survival (P=0.0056). Weight loss before the operation (P=0.097), Tumor site (P=0.002), stage T4b (P=0.016), an ACE-27 index of 2-3 (P=0.040), operation time≥8h (P=0.001) and Clindamycin as antibiotic prophylaxis (P=0.001) were significantly associated with POCs.ConclusionsThe occurrence of POCs significantly leads to worse short-term outcomes and increases the patients’ burden.

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Section: Perioperative Factors (Operation Time and Antibiotic Prophyl...contrasting

confidence: 60%

Section: Covariatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data

Wang

Wei

et al. 2022

Front. Oncol.

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“…In contrast, the phenomenon of "obesity paradox" is dominated in recent literatures 9 . It is believed that, poor nutritional intake and tumor cachexia might have contributed to low BMI documented in studies 18 . In present research, we found an association of low BMI with advanced stage tumor, which corroborates with recent data.…”

Section: Discussionmentioning

confidence: 99%

The obesity paradox - Is BMI associated with advanced stage in oral cancer?

Anwar¹,

Baig²,

Shaikh³

et al. 2023

PJMHS

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Background: Recent studies have shown that cancer patients with low BMI have poor outcomes. Their results suggest, obesity have some protective effect in cancer termed as “obesity paradox”. Aim: To examine the association of BMI with prognostic indicators of oral squamous cell carcinoma (OSCC). Methodology: This multicenter cross-sectional study was conducted during the year 2020 and 2021. 126 patients recently diagnosed with OSCC were randomly selected from three different tertiary care setup in Karachi. Height and weight of each subject was recorded to calculate BMI and clinicopathological data was obtained. The BMI indices were categorized into low, normal and high strata according to WHO guidelines. Statistical analysis was done for association of independent factors with BMI strata. Results: We found 81(64.3%) participants were underweight compared to 32(25.4%) normal-weight and 13(10.3%) overweight cases. A strong statistical association was observed between low BMI (83.1% underweight) and advanced tumor stage i.e., Stage IV (P= 0.001) while among risk factors of OSCC, only smokeless tobacco showed significant association (P= 0.002) with reduced BMI. This research brings attention to the importance of BMI in cancer and add to the growing literature in the field of oncology. Our findings about the impact of BMI on OSCC outcome will help in the intervention and development of prevention strategies for one of the most prevalent cancers in Pakistan. This present research will help to answer the complex question of “optimum” BMI in cancer and will help to improve the prognosis of OSCC. Conclusion: Our findings suggested that low BMI could be an indicator of poor clinical outcomes in OSCC. We thus recommend monitoring of BMI in OSCC patients in order to optimize treatment strategies. However, we encourage further studies to examine other body composition metrics for individualized treatments and intervention strategies. Keywords: Adiposity, Obesity paradox, Squamous cells, carcinoma, BMI

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“…Penurunan berat badan merupakan salah satu gejala yang dikeluhkan oleh pasien pada penelitian lain. Indeks massa tubuh yang rendah juga dihubungkan dengan prognosis yang lebih buruk (Wang et al, 2019), (Li et al, 2015). Pekerjaan pasien terbanyak adalah buruh pabrik dan petani, hal ini berkorelasi dengan penelitian lain yang menyebutkan bahwa salah satu faktor risiko terjadinya KSS adalah riwayat paparan sinar matahari dalam jangka waktu lama (Sari et al, 2021).…”

Section: A Pembahasanunclassified

Karakteristik Pasien Karsinoma Sel Skuamosa Telinga dan Tulang Temporal Di RSUP Dr. Hasan Sadikin Bandung

Lestari

Mahdiani

Purwanto

2022

SLJIL

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Keganasan pada liang telinga merupakan kasus yang jarang terjadi, kurang dari 0.2% dari seluruh keganasan pada regio kepala dan leher. Secara histologis karsinoma sel skuamosa (KSS) merupakan jenis karsinoma terbanyak karena terjadi pada 80% kasus keganasan pada telinga luar. Prognosis KSS biasanya buruk dan mengancam jiwa. TUJUAN: Penelitian bertujuan untuk mengidentifikasi karakteristik klinis pasien KSS di RSUP Dr. Hasan Sadikin Bandung. Penelitian deskriptif dari data rekam medis pasien KSS telinga dan tulang temporal di RSUP DR Hasan Sadikin Bandung periode Januari 2014 - Desember 2019. Didapatkan 49 pasien dengan KSS telinga dan tulang temporal, laki-laki dan perempuan sebesar 3:1.75. Usia termuda adalah 21 tahun dan tertua 62 tahun, umumnya bekerja sebagai petani dan buruh pabrik. Mayoritas IMT adalah kategori underweight dan normal. Predileksi KSS terbanyak di liang telinga (79.5%), sebanyak 57.1% dengan limfadenopati leher, sejumlah 10.2% dengan paralisis nervus fasialis HB V, dan gangguan pendengaran tipe konduktif derajat berat sebanyak 44.8%. Berdasarkan klasifikasi histopatologi, didapatkan 89.7% pasien tipe well differentiated, dengan 28.5% disertai metastasis, dan sebanyak 57.1% berada pada stadium IV. Tatalaksana yang dilakukan sebagian besar adalah operasi diikuti radioterapi, dengan angka kesembuhan 18.3% dan rekurensi 12.2%. KSS adalah keganasan telinga dan tulang temporal yang paling umum, namun jarang ditemukan di praktik sehari-hari. Gejala KSS menyerupai kelainan telinga jinak dan sifatnya agresif, biasanya pasien datang ketika sudah dalam stadium lanjut sehingga memiliki prognosis buruk dan mengancam jiwa. Angka harapan hidup yang lebih baik akan dicapai dengan diagnosis dan tatalaksana sedini mungkin pada pasien dengan risiko tinggi.

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Relationship between body mass index and outcomes for patients with oral squamous cell carcinoma

Abstract: Obesity may contribute to a higher recurrence rate and a worse prognosis in OSCC patients than in normal-weight patients in northern China. However, underweight patients have a higher risk of postoperative complications.

Cited by 10 publications

References 35 publications

Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data

Postoperative Complications of Free Flap Reconstruction in Moderate-Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study Based on Real-World Data

The obesity paradox - Is BMI associated with advanced stage in oral cancer?

Karakteristik Pasien Karsinoma Sel Skuamosa Telinga dan Tulang Temporal Di RSUP Dr. Hasan Sadikin Bandung

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