Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women

Haliloğlu, Berna; Aksungar, Fehime Benli; İlter, Erdin; Peker, Hakan; Akın, Figen Temelli; Mutlu, Nilgün; Özekici, Ümit

doi:10.1007/s00404-009-1297-4

Cited by 40 publications

(33 citation statements)

References 24 publications

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“…Herrman et al [21] failed to find association between Hcy and BMD similar to previous study in the group of postmenopausal Iranian women [17]. Similar to our results recent study of Haliloglu et al [20] showed that vitamin B 12 , folate and Hcy levels were not related with BMD [20].…”

Section: Discussionsupporting

confidence: 88%

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Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Rumbak

Žižić

Sokolić

et al. 2011

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 88%

“…Contrary to all mentioned studies, recent research reported no association between folate, vitamin B 12 , Hcy levels and BMD [20], while Herrmann et al [21] reported no significant relations between Hcy and BMD measured at different sites [21].…”

Section: Introductionmentioning

confidence: 94%

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Rumbak

Žižić

Sokolić

et al. 2011

Arch Gynecol Obstet

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show abstract

“…Eight studies [18, 21, 22, 24–26, 28, 29] were conducted in Turkey, 4 [6, 15, 31, 34] were from Italy, and the others were from India [32], UK [30], Morocco [27], Iran [23], and China [33], respectively. The study size was relatively small with the number of cases ranging from 22 to 110 and the number of controls from 15 to 110.…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

et al. 2016

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Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.

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“…It was found that vitamin B12 and folate are correlated with BMD in postmenopausal women and the possibility of involvement of a mechanistic link was suggested [37]. …”

Section: Discussionmentioning

confidence: 99%

Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women

et al. 2014

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BackgroundIn spite of several studies, the impact of homocysteine level and folic acid supplementation on bone metabolism is yet to be recognized. In this registered clinical trial (IRCT2014042217385N1), we aimed to find out the power of 6-month folic acid supplementation on homocysteine level and bone metabolism.MethodsForty postmenopausal osteoporotic women (50 to 87 years) were enrolled in the study. All participants were randomized to receive folic acid 1 mg (n = 17) or placebo (n = 14). At baseline, 3 months, and finally 6 months post intervention, the level of homocysteine, vitamin B12, and bone biomarkers were measured.ResultsBoth groups were similar at baseline. The homocysteine decreased in both groups but statistically non-significant (P > 0.05). The changes of the serum level of vitamin B12, osteocalcin, and β cross laps were significant between groups after 6 months (P ≤ 0.05).ConclusionThe trend of changes of bone biomarkers after 6 months folic acid supplementation shows that homocysteine concentration and/or folic acid supplementation have impact on the rate of bone metabolism. However, further investigations by larger sample size and differentiating age and gender are still needed to clarify the exact role of folate, homocysteine and vitamin B12.

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Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women

Abstract: Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers.

Cited by 40 publications

References 24 publications

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women

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