Relationship between bone mineral density and alcohol intake: A nationwide health survey analysis of postmenopausal women

Jang, Hae‐Dong; Hong, Jae Young; Han, Kyungdo; Lee, Jae Chul; Shin, Byung-Joon; Choi, Seok Keun; Suh, Seung Woo; Yang, Jae Hyuk; Park, Si Young; Bang, Chungwon

doi:10.1371/journal.pone.0180132

Cited by 54 publications

(30 citation statements)

References 27 publications

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“…Garddini et al [10] defined moderate drinking as the regular (≥3 d/week) consumption of ≤14 g/d EtOH for women and ≤28 g/d EtOH for men, suggesting that light to moderate alcohol consumption may exert beneficial effects on aBMD, but heavy alcohol consumption has negative effects on bone quality. Our results are partially in agreement with previous findings reporting beneficial effects on aBMD (≥2 times per week) [10,14,19]. This could occur, in part, due to decreased bone resorption [41].…”

Section: Discussionsupporting

confidence: 93%

“…Similarly, the highest aBMD was exhibited in postmenopausal women (mean 62.8 ages) who drank 2-3 times per week compared to the non-drinkers [19]. In terms of volumetric BMD (vBMD, g/cm 3 ) measured by high-resolution peripheral quantitative computed tomography, Paccou et al [17] found that men (mean 76.1 years) who consumed low amounts of alcohol had a lower vBMD, but women (mean 76.5 years) with moderate/high alcohol intake had a significantly higher vBMD.…”

Section: Discussionmentioning

confidence: 89%

“…All of these factors can interplay to produce conflicting results on human skeletons. Unfortunately, most of the previous studies investigating the relationship between alcohol consumption and areal bone mineral density (aBMD) have focused on either middle-aged/older men and/or middle-aged/postmenopausal women [16][17][18][19][20]. Very few studies have examined the relationship between alcohol and bone in young adults [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

Sung

Singh

et al. 2019

IJERPH

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The purpose of this cross-sectional study was to determine the differences in areal bone mineral density (aBMD) based on alcohol consumption behaviors, bone-loading history as assessed by a bone-specific physical activity questionnaire (BPAQ), and the body mass index (BMI). College-aged female students (N = 112) were recruited from the universities in Seoul and Gyeonggi province, South Korea. The aBMD of the lumbar spine and non-dominant side of the proximal femur (total hip, TH; femoral neck, FN; femoral trochanter, FT) were measured using dual energy X-ray absorptiometry (DXA). Alcohol consumption was determined by the frequency and amount of alcohol intake during the past 12 months using a self-reported questionnaire. The X-scan plus II was used to measure height (cm), body mass (kg), fat-free mass (FFM, kg), and % body fat. Drinking two or more times alcohol per week was associated with greater aBMD of the TH (p = 0.04–0.002) and FN (p = 0.043) compared to a lower frequency of alcohol consumption and 2–4 times per month, respectively. Based on the drinking amount per occasion, there were no significant group differences (p > 0.05) in aBMD at any of the sites. The highest group of total BPAQ had greater aBMD of the TH, FN, and FT versus the lowest (p = 0.023–0.009) and mid of total BPAQ groups (p = 0.004–0.009). Additionally, the highest group had greater aBMD of the lumbar spine compared to the mid group (p = 0.001). No significant group differences in aBMD at any of the sites were noted based on the BMI (p > 0.05). Young college-aged women with greater bone-loading physical activity showed greater aBMD at the TH, FN, FT, and lumbar spine, while a moderate alcohol intake was associated with greater aBMD of the TH and FN. These findings have clinical implications for young women who may not participate in high-impact physical activity and are binge drinkers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

Sung

Singh

et al. 2019

IJERPH

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“…High consumption of alcohol is expected to have a negative effect on BMD. 60,61 Higher calcium intake is associated with decreased bone loss, but alcohol consumption is correlated with low calcium level and bone loss. However, when both alcohol and calcium intake are high, decreased bone loss is observed.…”

Section: Lifestylementioning

confidence: 99%

<p>Bone-mineral density: clinical significance, methods of quantification and forensic applications</p>

Kranioti¹,

Bonicelli²,

García-Donas³

2019

RRFMS

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Bone-mineral density (BMD) is a measure of the inorganic mineral content in bone, and is one of the more informative assessments of bone quality in both clinical studies and forensic investigations. Several factors, such as age, sex, disease, genetics, and lifestyle, affect BMD measurements, and normative standards must be applied for specific groups and individuals. One of the most common disorders associated with low BMD is osteoporosis and increased fracture risk, due to a decrease in bone strength and an increase in bone fragility. Medical conditions like diabetes or hyperthyroidism and other parameters like peak bone mass and postmenopausal estrogen deficiency also impact BMD. Single-and dualenergy photon absorptiometry, quantitative computet tomography, and magnetic resonance imaging are some of the technological modalities for BMD quantification, and each presents distinct advantages and limitations, depending on the purpose of the analysis, the specific characteristics of the individual, the bone site under examination, and the equipment and trained personnel available. Recently, BMD values were applied to forensic medicine in a variety of scenarios ranging from age and sex estimation to the assessment of malnutrition and the use of finite-element modelling. Despite technical and methodological inconsistencies reported in the literature on BMD readings, there is scope for expanding the use of this variable in forensic settings.

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“…Alcohol consumption affects bone metabolism, bone mass, and bone strength. Light alcohol consumption provides several beneficial effects to bone 12,13 , whereas heavy CAC is detrimental to bone and is known to induce secondary osteoporosis 13,14 . The decrease in bone mass and strength following CAC might be due to bone remodeling imbalance with a predominant decrease in bone formation 14,15 .…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice

et al. 2018

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Background: Alcohol dehydrogenase 3 (ADH3) plays major roles not only in alcohol metabolism but also in nitric oxide metabolism as S-nitrosoglutathione reductase (GSNOR). ADH3/GSNOR regulates both adipogenesis and osteogenesis through the denitrosylation of peroxisome proliferator-activated receptor γ. The current study investigated the contribution of ADH3 to the development of alcoholic osteoporosis in chronic alcohol consumption (CAC). Methods:Nine-week-old male mice of different ADH genotypes [wild-type (WT) and Adh3 −/− ] were administered a 10% ethanol solution for 12 months. The femurs were evaluated by histochemical staining and computed tomography-based bone densitometry. The mRNA levels of ADH3 were evaluated in the WT mice by reverse transcription-quantitative polymerase chain reaction. Results:The Adh3 −/− control mice exhibited increased activities of both osteoblasts and osteoclasts and lower bone masses than the WT control mice. CAC exhibited no remarkable change in osteoblastic and osteoclastic activities, but decreased bone masses were observed in WT mice despite an increase in the mRNA levels of ADH3. Conversely, bone masses in the Adh3 −/− control mice were not reduced after CAC. Conclusions:The Adh3 −/− control mice exhibited a high turnover of osteoporosis since osteoclastogenesis dominated osteoblastogenesis; however, bone resorption was not enhanced after CAC. In comparison, CAC lead to alcoholic osteoporosis in WT mice, accompanied by increased mRNA levels of ADH3.Hence, ADH3 can prevent osteoporosis development in normal ADH genotypes with no alcohol ingestion. However, ADH3 contributes to the development of alcoholic osteoporosis under CAC by participating in alcohol metabolism, increasing metabolic toxicity, and lowering GSNO reducing activity. (J Nippon Med Sch 2018; 85: 322 329) Key words: ADH3, GSNOR, alcoholic osteoporosis, chronic alcohol consumption, osteoclastogenesis ria to humans and ubiquitously distributed in mammalian tissues 3 . Several unique functions have been recognized, such as alcohol metabolism, detoxification of formaldehyde, and S-nitrosoglutathione (GSNO) reducing

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Relationship between bone mineral density and alcohol intake: A nationwide health survey analysis of postmenopausal women

Cited by 54 publications

References 27 publications

Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

Bone-Loading Physical Activity and Alcohol Intake but not BMI Affect Areal Bone Mineral Density in Young College-Aged Korean Women: A Cross-Sectional Study

<p>Bone-mineral density: clinical significance, methods of quantification and forensic applications</p>

The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice

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