Relationship between breast arterial calcification and lipid profile, plasma atherogenic index, Castelli's risk index and atherogenic coefficient in premenopausal women

Yıldız, Atilla; Seçen, Özlem; Yıldız, Cennet; Çiçekçi, Mehtap

doi:10.1016/j.ijcme.2016.05.003

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Negative changes in the levels of lipids and lipoproteins are crucial factors for the development of diseases of the cardiovascular system and to evaluate this trend in individuals with dyslipidemias, indexes that correlate values of lipids and lipoproteins, such as the indexes of Castelli I and II and the Triglyceride/HDL‐c ratio. However, the groups treated with phthalimides had only a small increase in the Castelli indexes, playing a role in the reduction of cardiovascular risk quite significant [22–23] …”

Section: Resultsmentioning

confidence: 94%

“…However, the groups treated with phthalimides had only a small increase in the Castelli indexes, playing a role in the reduction of cardiovascular risk quite significant. [22][23] In this study we also evaluated the triglyceride/ HDL-c ratio (TG/HDL-c), a measure of the particle size of LDL-c for ratios greater than 1 (> 1), indicating very small and high density particles, which are closely related to the development of atherosclerotic process, being this measure a good indicator of atherogenesis and therefore, an indicator of myocardial infarction. [24] Data obtained from this ratio compared to other studies show that the LDL-C particle size of the untreated and hyperlipid diet group is less than 25 nm, a favorable condition for the deposition of this lipoprotein in the vascular lumen, causing vascular diseases.…”

Section: Discussionmentioning

confidence: 99%

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Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance

Júnior

Araújo

Rocha

et al. 2022

Chemistry & Biodiversity

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Alterations in lipid and lipoprotein metabolism are factors that trigger several negative metabolic complications. Hyperlipidemia is the starting point for the development of comorbidities of the cardiovascular system, such as atherosclerosis. The search for compounds that reduce high levels of total cholesterol and triglycerides has been widely reported in several publications in the literature. Phthalimide derivatives have been extensively researched with various biological actions. In this study we evaluated the antihyperlipidemic ability of three phthalimide derivatives (FGT-2, FGT-3 and FGT-4) on a model of obesity and insulin resistance in mice. The animals were submitted to a hyperlipid diet for 60 days. On the thirtieth day they were treated with phthalimides (20 mg/kg). The positive control group was treated with Simvastatin (20 mg/kg) and the negative control received only the carboxymethylcellulose vehicle. Biochemical and histological analyzes of all groups were analyzed. The animals treated with phthalimidic derivatives had a reduction in total cholesterol, low density and very low density lipoproteins (LDL-c and VLDL-c), triglycerides and fasting glycemia when compared to the negative control group. The treated animals also showed good results when analyzing the atherogenic indexes Castelli i and II and the ratio Triglycerides/HDL-c. In the oral glucose tolerance test and in the insulin tolerance test, animals treated with phthalimides were more sensitive to the action of the hormone regulating carbohydrate uptake. In the evaluation of the transaminases (AST/ALT), the animals of the group treated with phthalimides presented a lower elevation than the other groups of the experiment, the same observed with the uric acid evaluation. Histological analyzes were performed on liver, kidney, heart and pancreas samples. The groups treated with the compounds FGT-2 and FGT3 presented discrete alterations in the liver and kidney. FGT-4 did not present histological alterations for both tissues and the three phthalimide derivatives did not cause alterations in the other organs. These results suggest that the phthalimides tested can act as antihyperlipidemic agents and have a pleiotropic action, by acting also reducing glycemia in insulin resistance model mimicking diabetes mellitus type 2. These compounds may appear as a new approach in the treatment of obesity and complications, which are multifaceted.

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Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance

Júnior

Araújo

Rocha

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…This research is the first study to examine the status of the atherogenic indices and lipid ratios in women living in Tabriz, Iran. The previous observations suggested that lipid ratios could be used for detecting subjects at higher risk of CVD and atherosclerosis when all values of lipoproteins seem normal and/or TG concentrations are elevated [12].…”

Section: Discussionmentioning

confidence: 99%

“…The atherogenic coefficient (AC), the ratio of non-HDL-C to HDL-C, is another ratio that relies on the significance of HDL-C in predicting the risk of CAD [12]. Cholindex (CI), the net effect of atherogenicity, is calculated by subtracting HDL-C from LDL-C.…”

Section: Introductionmentioning

confidence: 99%

Assessment of atherogenic indices and lipid ratios in the apparently healthy women aged 30–55 years

Gol

Rafraf

Jafarabadi

2022

Arterial Hypertension

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Background: Cardiovascular disease (CVD) is the main cause of death worldwide and atherogenic dyslipidemia is an established risk factor for CVD. This cross-sectional study aimed to assess the atherogenic indices and lipid ratios, including atherogenic coefficient (AC), atherogenic index of plasma (AIP), cholindex (CI), Castelli risk index-1 (CRI-1), CRI-2, and non-HDL-C, in women living in the Tabriz, Iran during April-May 2017. Material and methods: Anthropometric measurements, fasting serum lipids, and blood pressure of 150 women aged 30-55 years in Tabriz, Iran was evaluated. The atherogenic indices were calculated by the established formulas.

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“…In the OMN group, the highest mean values of LDL-C, non-HDL-C, and TC/HDL-C ratios compared to the other groups were observed. It should be pointed out that, according to the latest ESC/EAS guidelines [45], the non-HDL-C ratio is a vital risk factor [58][59][60].…”

Section: Cardiovascular Risk Factorsmentioning

confidence: 99%

Is It Feasible to Predict Cardiovascular Risk among Healthy Vegans, Lacto-/Ovo-Vegetarians, Pescatarians, and Omnivores under Forty?

Kwiatkowska

Olszak

Brożek

et al. 2023

IJERPH

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Guidelines for cardiovascular (CV) risk assessment among young adults are uncertain. Researchers are still looking for new tools for earlier diagnosis of cardiovascular diseases (CVD), the leading cause of mortality in the modern world. This study aimed to assess whether CV risk estimation is possible in groups of healthy individuals under the age of 40 on different dietary patterns (vegans—VEGAN (n = 48), lacto-/ovo-vegetarians—VEGE (n = 49), pescatarians—PESCA (n = 23), and omnivores—OMN (n = 35)) during the pandemic period. Four metrics containing selected risk classifiers were created, and participants were assessed using them. Groups including meat consumption showed increased CV risk predictions in the metrics assessment. The next analyzes showed statistically significant relationships between the results from the created metrics and selected non-basic biomarkers for ApoA1 (OMN group, p = 0.028), IL-6 (PESCA group, p = 0.048), HCY (VEGAN group, p = 0.05), and hsCRP (OMN + PESCA groups, p = 0.025). We found that predicting CV risk among healthy people under 40 adhering to different dietary patterns, taking into account basic and non-basic laboratory assessments and created metrics, is challenging but feasible. Furthermore, the OMN group appeared to be at the highest risk of increased CV risk in the future, while risk tended to be the lowest in the VEGAN group.

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Relationship between breast arterial calcification and lipid profile, plasma atherogenic index, Castelli's risk index and atherogenic coefficient in premenopausal women

Cited by 10 publications

References 25 publications

Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance

Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance

Assessment of atherogenic indices and lipid ratios in the apparently healthy women aged 30–55 years

Is It Feasible to Predict Cardiovascular Risk among Healthy Vegans, Lacto-/Ovo-Vegetarians, Pescatarians, and Omnivores under Forty?

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