Relationship between C-Reactive Protein, White Blood Cell Count and Metabolic Syndrome in Nigerians with Type 2 Diabetes Mellitus

Abstract

Background: Presence of metabolic syndrome (MS) in people with diabetes confers increased cardiovascular and diabetes-specific micro-and macrovascular complications. The pathogenic pathways for metabolic syndrome are still issues for discussion especially in some special groups like those with type 2 diabetes mellitus (T2DM). Recent evidences suggest that inflammation may play a key role in MS. This study assessed the relationship between MS (and its component risks) and markers of inflammation (high-sensitivity C-reactive protein {hs-CRP} and white blood cells {WBC}). Methods: A cross-sectional study involving 108 patients with T2DM. Anthropometric measurements and clinical examination were conducted. Blood sample was collected for hs-CRP, WBC, glycated haemoglobin etc. Metabolic syndrome was defined using the International Diabetes Federation criteria. Ethical approval was granted and informed consent was obtained from participants. Results: Mean age of male and female participants were 58.00 ± 7.01 years and 55.48 ± 8.35 years respectively (p = 0.092). Eighty-two (75.9%) participants had metabolic syndrome. Median values of hs-CRP and total WBC were 0.89mg/L and 5.73 x10 3 /mm 3 respectively. On correlation, hs-CRP showed statistically significant association with waist circumference (r = 0.194; p = 0.044), fasting plasma glucose (r = 0.191; p = 0.048) and serum triglycerides (p = 0.226; r = 0.019). There was no statistically significant association between WBC and the metabolic components. Conclusion: Prevalence of metabolic syndrome is high, and C-reactive protein was associated with waist circumference, fasting plasma glucose and serum triglycerides.How to cite this paper: Soyoye, D.O.,

Serum Calcium, Magnesium and Creactive protein levels in female Metabolic Syndrome patients

“…[6][7][8][9][10][15][16][17] One study result revealed no significant elevation of CRP in Mets patients. 18 Though there is some evidences of altered calcium, magnesium and CRP levels in MetS patients in separate studies of different countries in the world, there is no informed published data available in reproductive age group female in Bangladesh. Therefore, this study has been designed to assess serum calcium, magnesium and CRP status in a small cross section of female MetS patients in Bangladesh.…”