Relationship between caga-positive Helicobacter pylori infection and risk of gastric cancer: a case control study in Porto Alegre, RS, Brazil

Meine, Gilmara Coelho; Rota, C.; Dietz, Judite; Sekine, Setsuo; Prolla, João Carlos

doi:10.1590/s0004-28032011000100009

Cited by 17 publications

(11 citation statements)

References 37 publications

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“…Even with no proven association between the presence of H. pylori infection and any specific symptom (18) , one could expect to find a higher prevalence of cagA-positive strains than we actually did (29.6%) considering that patients in our sample had more severe clinical presentations (11) . Previous studies with adults from southern Brazil, including from southern Brazil, including from Porto Alegre, found prevalence rates of cagA-positive infection ranging from 65% to 71% (24,26) , as well as an association between presence of this gene and duodenal ulcer (26) and gastric cancer (19) . The difference between adults and children from the same population may denote a different behavior of the infection in children (18,20,31) .…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Oliveira

Ferreira

Camerin³

et al. 2014

Arq. Gastroenterol.

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-Context -Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. Objective -Describe the prevalence of infection with cagA-positive H. pylori strains in a group of children and adolescents who underwent esophagogastroduodenoscopy in Porto Alegre, Rio Grande do Sul. Methods -Fifty-four gastric biopsy specimens of children and adolescents with H. pylori infection demonstrated by histology, urease test and molecular analysis were tested for the presence of cagA-positive H. pylori strains by the polymerase chain reaction method. Results -The prevalence of cagA-positive H. pylori was 29.6% (95% confidence interval, 18 to 43.6%). There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histological features of patients infected with cagA-positive strains as compared with those infected by cagA-negative strains. Conclusions -The study showed a low prevalence of infection with cagA-positive H. pylori strains among children and adolescents who underwent EGD in southern Brazil, in comparison to studies conducted with children from other regions of Brazil. There was no association between the presence of cagA-positive strains and more severe clinical presentations in the studied sample.

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Section: Discussionmentioning

confidence: 94%

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Oliveira

Ferreira

Camerin³

et al. 2014

Arq. Gastroenterol.

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“…Almost certainly, these include a more varied diet and better food conservation, including refrigeration, as well as control of infection by Helicobacter pylori (H pylori) (22,23) , decreasing of risk factors exposure, such as consumption of salt and salty foods, which can lead to damage of the protective layer of the mucosa of stomach (11,22) and smoking (18) .…”

Section: Discussionmentioning

confidence: 99%

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Guimarães

Muzi

2012

Arq. Gastroenterol.

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CONTEXT: The most recent global estimate revealed the presence of about one million new cases of stomach cancer for the year 2008, setting itself as the fourth most common cause of cancer. OBJECTIVE: The present study aims to assess the trend of mortality from stomach cancer in Brazil according to regions between 1980 and 2009. METHODS: Data on deaths from stomach cancer were obtained from the Mortality Information System, and the demographic data, from the Brazilian Institute of Geography and Statistics. The rates of mortality were standardized by age according to world population. The trend curves were calculated for Brazilian regions by sex. The technique used was polynomial regression and joinpoint. RESULTS: The tendency for males and females is similar in all regions, although the magnitude is higher among men in all places. Regions Midwest, South, Southeast tended to decline, while the Northern region showed no significant trend, and the Northeast tended to increase. CONCLUSION: It is therefore a need to evaluate public health policies for gastric cancer aimed at the demographic transition (change of urbanization and lifestyle) that is occurring throughout the country.

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“…Helicobacter pylori ( H. pylori ) infection constitutes a public health concern in developed and developing countries [ 1 , 2 ], since it was associated with chronic gastritis, gastric and duodenal ulcers, and gastric adenocarcinoma in humans, as well as mucosa-associated lymphoid tissue lymphoma [ 3 - 6 ]. In the year 1994, the International Agency for Research on Cancer of WHO classified H. pylori as a Type I, or definite carcinogen to humans and reconfirmed this classification in 2009 [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori glmM gene in bovine milk using Nested polymerase chain reaction

Osman

Eleragi

Musa³

et al. 2015

Vet World

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Aim:The aim was to detect the glmM gene of Helicobacter pylori (H. pylori) in cow’s milk from different dairy farms in Khartoum State using Nested polymerase chain reaction (PCR).Materials and Methods:A total of 50 milk samples were collected from different dairy farms in Khartoum State (13 from Khartoum, 24 Khartoum North, and 13 from Omdurman Provinces).Results:The generated results showed that 11/50 (22%) were harboring the investigated H. pylori glmM gene in Khartoum State (1/13 [7.7%] Khartoum, 9/24 [37.5%] Khartoum North, and 1/13 [7.7%] Omdurman provinces, respectively).Conclusion:To the best of our knowledge, this was the first report on the detection of H. pylori glmM gene in cattle milk in Khartoum State. Nonetheless, the high percentages of H. pylori DNA detection in milk opened new avenues toward exploring the risk of human infection with H. pylori through the consumption of raw milk.

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Relationship between caga-positive Helicobacter pylori infection and risk of gastric cancer: a case control study in Porto Alegre, RS, Brazil

Cited by 17 publications

References 37 publications

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Prevalence of Infection With Caga-Positive Helicobacter Pylori Strains Among Children and Adolescents in Southern Brazil

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Detection of Helicobacter pylori glmM gene in bovine milk using Nested polymerase chain reaction

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