Relationship between calcium-antagonist, antiaggregant, and antiarrhythmic activity of benzimidazole derivatives and their anticalmodulin activity

Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats

“…Benzimidazoles are heterocyclic aromatic organic compound having structural analogy to nucleotides found in human body and hence are an important pharmacophore in medicinal chemistry [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] . They are known to exhibit Rho-kinase (ROCK) inhibitory activity and thus could be considered as novel potential class of anti-glaucoma therapeutics [14] , [15] , [16] .…”

“…Data in this article is to present the effects of benzimidazole-based compounds on IOP of ocular normotensive rats and is supplementary to [1 , 2] . These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole [1] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] .…”

“… Data format Analyzed Experimental factors This data is supplementary to [1 , 2] . A total of 27 new compounds were synthesized as described previously [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] and tested for IOP lowering effect in rats. These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole.…”