My parents, Vaibhav and Vaidehiiii The more I read, the more I meditate; and the more I acquire, the more certain I am that I know nothing.-Voltaire iv ACKNOWLEDGMENTS I would, foremost, like to convey my gratitude to my advisor and guru Dr. Steven M.Levy, who has played the role of a great motivator and teacher with his unceasing support and guidance that have shaped this thesis. He has had a profound and phenomenal effect on the way I perceived the science of dentistry, research and life overall. I convey my deepest gratitude to Dr. Warren, Dr. Marshall and Dr. Cavanaugh for rendering their time and expertise in the making of this thesis and for being part of my committee. I would like to thank Mrs. Barbara Broffitt for her immense help with the IFS data and Mr. Ke Liu and Ms.Carmen Smith for offering statistical consultation.I take pride in thanking my father Dr. Raj S. Yaduwanshi, whose passion in dentistry and service to people left a strong impression on my life from a very tender age. I thank my mother Mrs. Krishna R. Yaduwanshi, a strong willed, passionate and righteous woman, who has been the pillar of strength all my life. I thank my daughter Vaidehi and my husband Vaibhav for being patient in this journey, for enriching it with their selfless love and countless sacrifices, and for allowing me to stay devoted to my research. I would also like to thank my father and mother-in-laws-Mr. Shrikant and Mrs. Saroj Yadav for their love, blessings and for backing me with their optimism. Last but not the least; I thank Akshay and Shreshtee-my loving brothers, for being there for me when I needed them most.
ABSTRACTObjective: To determine risk factors for cavitated caries incidence and extent of cavitated caries among adolescents.Methods: Three hundred and three Iowa Fluoride Study (IFS) subjects met inclusion criteria for interval between dental examination and the responses from the IFS (ages 13.5 to 17.0) and the Block Kids Food Frequency (ages 13.0 to 17.0) questionnaires, respectively. The analyses focused on the outcome variables of net cavitated caries incidence and net cavitated caries increment counts, respectively. The independent IFS questionnaire variables related to demographics, fluorides, oral hygiene, beverage intakes, dental visits, sealants and previous caries incidence variables, respectively, whereas, Block's questionnaire variables related to intakes of solid foods and beverages, respectively. Two sets of analyses, logistic and negative binomial regression analyses, were conducted to assess the associations between risk factors and net cavitated caries incidence and increment counts from 13 to 17, respectively.Results: In multivariable logistic regression analyses, significant (p<0.05) negative associations were found between age 13 to 17 net cavitated caries incidence and greater frequency of consumption of vegetables, greater brushing frequency and greater frequency of sugar-free beverage consumption. Additionally, significant (p<0.05) positive associations were found between age 13 to 17 ne...