Relationship between Changes in Components Associated with Metabolic Syndrome and Disappearance, or Remission, of Metabolic Syndrome during 1 Year

Chang, Hsiao-Chien; Horng, Jorng-Tzong; Chau, Tran Thi Minh; Chen, Y. W.; Hsieh, Chuan Fa; Chang, Chih-Jen; Hsiao, Tsun-Wen

doi:10.1177/030006051204000629

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…This study is the first study assessing the impact of thyroid function on the regression of dyslipidemia and its components. To our best knowledge, the disappearance of metabolic syndrome was common (30%), mainly due to a reduction in TG and an increase in HDL-C. [ 16 ] In our study, high normal FT4 levels showed an independent association with the regression of dyslipidemia, especially high TG and low HDL-C status, in adult males.…”

Section: Discussionsupporting

confidence: 52%

The correlation between serum free thyroxine and regression of dyslipidemia in adult males

et al. 2017

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Elevated free thyroxine (FT4) levels may play a protective role in development of dyslipidemia. However, few prospective studies have been performed to definite the effects of thyroid hormones on the improvement of dyslipidemia and its components. Thus, this study aims to clarify the association between thyroid hormones within normal range and reversal of dyslipidemia in the absence of intervention.A prospective analysis including 134 adult males was performed between 2010 and 2014. Anthropometric parameters, thyroid function, and lipid profile were measured at baseline and during follow-up. Logistic regression and receiver operating characteristic (ROC) analysis were conducted to identify the variables in forecasting the reversal of dyslipidemia and its components.During 4.5-year follow-up, 36.6% (49/134) patients resolved their dyslipidemia status without drug intervention. Compared with the continuous dyslipidemia group, subjects in reversal group had elevated FT4 and high-density lipoprotein cholesterol (HDL-C) levels, as well as decreased total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels at baseline. Furthermore, baseline FT4 is negatively associated with the change percentages of TG (r = −0.286, P = .001), while positively associated with HDL-C (r = 0.227, P = .008). However, no correlation of lipid profile change percentages with FT3 and TSH were observed. Furthermore, the improving effects of baseline FT4 on dyslipidemia, high TG, and low HDL-C status were still observed after multivariable adjustment. In ROC analysis, areas under curve (AUCs) for FT4 in predicting the reversal of dyslipidemia, high TG, and low HDL-C were 0.666, 0.643, and 0.702, respectively (P = .001 for dyslipidemia, .018 for high TG, and .001 for low HDL-C).Higher FT4 value within normal range may ameliorate the dyslipidemia, especially high TG and low HDL-C status, in males without drug intervention. This suggests that a more flexible lipid-lowering therapy may be appropriate for patients with high-normal FT4.

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Section: Discussionsupporting

confidence: 52%

The correlation between serum free thyroxine and regression of dyslipidemia in adult males

et al. 2017

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“…This may be attributed to the risk factors pertaining to the participants who went on a diet compared with other subjects without any special diet. Also, another reason may be changes in the risk factors that affect the components of MetS in the participants during the 10 years of the study ( 38 ) .…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary habits on the risk of metabolic syndrome: Yazd Healthy Heart Project

Sarebanhassanabadi

Mirhosseini

Mirzaei

et al. 2017

Public Health Nutr.

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A prospective study of serum adiponectin and regression of metabolic syndrome: The ARIRANG study

Kim

Yadav

Ahn³

et al. 2015

Biochemical and Biophysical Research Communications

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Relationship between Changes in Components Associated with Metabolic Syndrome and Disappearance, or Remission, of Metabolic Syndrome during 1 Year

Abstract: Short-term weight reduction has no impact on the status of metabolic syndrome. The disappearance of metabolic syndrome was common during a 1-year follow-up. This finding might impact on the treatment and management of people with metabolic syndrome.

Cited by 5 publications

References 23 publications

The correlation between serum free thyroxine and regression of dyslipidemia in adult males

The correlation between serum free thyroxine and regression of dyslipidemia in adult males

Effect of dietary habits on the risk of metabolic syndrome: Yazd Healthy Heart Project

A prospective study of serum adiponectin and regression of metabolic syndrome: The ARIRANG study

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