Relationship between Childhood Physical Abuse and Clinical Severity of Treatment-Resistant Depression in a Geriatric Population

Abstract

Background: We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. Methods: Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres. Results: Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). Most of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0-60; moderate severity≥20, high severity≥35] and 16.5 (SD=4.94) [IDS-SR score range: 0-27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD=6.26) [range 0-30]. In an age and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β=0.274; p=0.07) and QIDS-SR (β=0.302; p=0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β=0.304; p=0.03) and QIDS-SR (β=0.362; p=0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b=0.318, 95% BCa C.I. [0.07, 0.62]; QIDS-SR: b=0.177, 95% BCa C.I. [0.04, 0.37]]. Preacher & Kelly’s Kappa Squared values of 19.1% (k2=0.191) and 16% (k2=0.16), respectively, indicate a moderate effect. Conclusion: To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms.

Parental Rearing and Conflict Resolution among College Freshmen Students

“…After adjusting for significant confounding variables, the results indicated that occasional physical violence or fights, long-term physical abuse, chronic cold violence or ignorance of each other, and even persistent conflict or silent treatment to resolve the conflict were linked to one year increased risk of developing first-onset MDD. Most research on the influencing factors of depression mainly focus on the impact of direct physical trauma (Yrondi et al, 2020). Growing up and developmental stages in different types of trauma exposure could have differential effects on brain structure and function (van Rooij et al, 2020).…”

Gydymui Atspari Depresija: Rizikos Veiksniai Ir Gydymas

“…Gydymui atsparią depresiją lemia skirtingi rizikos veiksniai: pasikartojantys depresijos epizodai, ankstyva depresijos pradža (<18 metų), gretutinės ligos (koronarinė širdies liga, hipotirozė), lėtinis skausmas, vartojami medikamentai (gliukokortikoidai, interferonai), neigiami gyvenimo įvykiai [4,18]. Ligos sunkumo rodikliai, prarasta priklausomybė darbo rinkai, nemiga, migrena bei psichotropinių vaistų Atsparios depresijos gydymo strategijos pacientams, kurie nereaguoja į pradinį gydymą antidepresantais, apima gydymo sustiprinimą (angl.…”