2015
DOI: 10.1007/s00417-014-2927-5
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Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt–Koyanagi–Harada disease

Abstract: Our data suggest that circulatory disturbances and increased thickness of the choroid relate to the pathogenesis of VKH disease with link mutually. LSFG is useful as an index for evaluating the choroiditis activity of VKH disease as well as EDI-OCT.

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Cited by 78 publications
(82 citation statements)
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“…In addition, excellent visual acuity was maintained over long-term follow-up, indicating that initial use of pulse intravenous corticosteroids in new-onset acute VKH disease may lead to long-term good visual outcomes and low rates of recurrence and complications. Our results are superior to a Japanese study by Hirooka and colleagues reporting that 69% of eyes with acute VKH disease achieved a visual acuity of 1.0 or better at 1 month 18. Of note in that study, patients received lower starting corticosteroid doses of prednisolone 200 mg/day.…”
Section: Discussioncontrasting
confidence: 83%
“…In addition, excellent visual acuity was maintained over long-term follow-up, indicating that initial use of pulse intravenous corticosteroids in new-onset acute VKH disease may lead to long-term good visual outcomes and low rates of recurrence and complications. Our results are superior to a Japanese study by Hirooka and colleagues reporting that 69% of eyes with acute VKH disease achieved a visual acuity of 1.0 or better at 1 month 18. Of note in that study, patients received lower starting corticosteroid doses of prednisolone 200 mg/day.…”
Section: Discussioncontrasting
confidence: 83%
“…At the initial onset of VKH disease, patients usually show signs of panuveitis or posterior uveitis with serous retinal detachment. Indocyanine green angiography (ICGA) and laser speckle flowgraphy reveal impaired choroidal circulation,4 5 and enhanced depth imaging optical coherence tomography (EDI-OCT) shows the markedly thickened choroid in eyes with VKH disease 5–7…”
Section: Introductionmentioning
confidence: 99%
“…17,33,47 Recent results also suggest that systemic corticosteroid therapy ameliorates the inflammation-related impairment of choroidal blood flow velocity in the macula of VKH patients. 17 In that study, LSFG was used to evaluate the effect of systemic corticosteroid administration by comparing measurements of blood flow velocity, which is considered to reflect inflammation activity in the choroid.…”
Section: Monitoring Ocular Circulationmentioning
confidence: 99%
“…17 Furthermore, decreased MBR and increased choroidal thickness, as measured with optical coherence tomography (OCT), have been reported to be mutually linked and to be related to the pathogenesis of VKH. 47 Thus, LSFG might be useful as an index for evaluating the activity of choroiditis in VKH, as a supplement to OCT. 47 In eyes with CSC, a negative correlation has been shown between visual recovery and decreased MBR with the regression of the disease, indicating that increase in macular choroidal MBR may be associated with a poor visual prognosis. 33 Moreover, the finding that MBR decreases concurrently with the regression of CSC provides additional evidence for the role of elevated choroidal blood flow in the pathogenesis of acute CSC.…”
Section: Monitoring Ocular Circulationmentioning
confidence: 99%