Relationship between Chronic Pain and Cognition in Cognitively Intact Older Persons and in Patients with Alzheimer’s Disease

Scherder, E.J.A.; Eggermont, L.H.P.; Plooij, Bart; Oudshoorn, Jeroen; Vuijk, Pieter Jelle; Pickering, Gisèle; Lautenbacher, Stefan; Achterberg, Wilco P.; Oosterman, Joukje M.

doi:10.1159/000113216

Cited by 59 publications

(53 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is worth noting that in some of the pathological conditions for which σ 1 agonists are being investigated, pain is one of the symptoms. Examples include recovery from stroke43, traumatic brain injury44 or spinal cord injury45, Alzheimer’s disease46, Parkinson’s disease47 and multiple sclerosis48. In addition, other diagnoses such as anxiety or depression often occur concomitantly to pain states49.…”

Section: Discussionmentioning

confidence: 99%

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

Entrena

Sánchez-Fernández

Nieto

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Sigma-1 receptor antagonists promote antinociception in several models of pain, but the effects of sigma-1 agonists on nociception (particularly when the nociceptive system is primed) are not so well characterized; therefore we evaluated the effects of sigma-1 agonists on pain under different experimental conditions. The systemic administration of the selective sigma-1 agonists (+)-pentazocine and PRE-084, as well as the nonselective sigma-1 agonist carbetapentane (used clinically as an antitussive drug), did not alter sensitivity to mechanical stimulation under baseline conditions. However, they greatly promoted secondary mechanical allodynia after priming the nociceptive system with capsaicin. These effects of sigma-1 agonists were consistent in terms potency with the affinities of these drugs for sigma-1 receptors, were reversed by sigma-1 antagonists, and were not observed in sigma-1 knockout mice, indicating that they are sigma-1-mediated. Repeated systemic treatment with PRE-084 induced proallodynic effects even 24 h after treatment completion, but only after the nociceptive system was primed. However, neither the presence of this drug in the organism nor changes in sigma-1 receptor expression in areas involved in pain processing explains its long-term effects, suggesting that sustained sigma-1 agonism induces plastic changes in the nociceptive system that promote nociception.

show abstract

Section: Discussionmentioning

confidence: 99%

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

Entrena

Sánchez-Fernández

Nieto

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…For example, Eccleston (1994) showed that pain affected performance on an attentional-interference task, but only when the task was at its most complex. Studies by Suhr (2003) and Scherder et al (2008), however, failed to show any executive function deficits in chronic pain patients. A study by Oosterman and colleagues (2009) actually found a positive relationship between self-reported pain and executive function (increased pain levels associated with improved cognitive function).…”

Section: Executive Functionmentioning

confidence: 95%

“…There are also studies that report no association between chronic pain and impaired cognitive function (Bell et al, 1999;Landro et al, 1997;Pincus et al, 1998;Scherder et al, 2008Suhr, 2003. Furthermore, functional deficits may manifest in the absence of measurable cognitive impairment.…”

Section: Appraisal and Caveats Of Clinical Literaturementioning

confidence: 99%

The effect of pain on cognitive function: A review of clinical and preclinical research

Moriarty

McGuire

Finn

2011

Progress in Neurobiology

900

710

View full text Add to dashboard Cite

Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical and preclinical studies that have investigated pain-related alterations in cognition. These include impaired attentional, executive and general cognitive functioning. We describe the anatomical, neurochemical and molecular substrates common to both cognitive processing and supraspinal pain processing, and present the evidence for their involvement in pain-related cognitive impairment. We also examine the added complexity of cognitive impairment caused by analgesic medications and how this can further impact on morbidity in chronic pain patients. The need for a better understanding of the mechanisms of both pain-induced and treatment-related cognitive impairment is highlighted. Further research in this area will aid our understanding of patient symptoms and their underlying pathophysiology, ultimately leading to increased provision of guided therapy.

show abstract

“…Extensive research has tested the common wisdom assumption that pain engages domain-general cognitive resources in non-human animals [21; 31; 32; 10; 9; 4], chronic pain patients [28; 52; 18; 68; 30; 74; 19; 51; 60], and healthy volunteers exposed to transient noxious stimuli [53; 78; 27; 1; 6; 14; 17; 57; 61; 20; 33–35; 58; 64; 69–71; 77; 55; 73; 2; 40; 63; 62; 12; 39; 56]. We can distinguish these studies according to the explicit hypothesis tested (Fig.…”

mentioning

confidence: 99%

Performance-dependent inhibition of pain by an executive working memory task

Buhle

Wager

2010

Pain

229

241

View full text Add to dashboard Cite

It is widely assumed that distraction reduces pain. Similarly, it is assumed that pain distracts from concurrent, unrelated cognitive processing, reducing performance on difficult tasks. Taken together, these assumptions suggest pain processing and cognitive function engage an overlapping set of domain-general, capacity-limited mental resources. However, experimental tests of this proposal have yielded mixed results, leading to alternative proposals that challenge the common model of a bidirectional relationship between concurrent pain and task performance. We tested these contrasting positions using a novel concurrent pain and executive working memory paradigm. Both task difficulty and nociceptive stimulus intensity were individually calibrated for each participant. Participants reported less pain during the working memory task than a visually matched control condition. Conversely, increasing levels of heat incrementally reduced task performance. Path analyses showed that variations in pain completely mediated this effect, and that even within a given heat level, trial-by-trial fluctuations in pain predicted decrements in performance. In sum, these findings argue that overlapping cognitive resources play a role in both pain processing and executive working memory. Future studies could use this paradigm to understand more precisely which components of executive function or other cognitive resources contribute to the experience of pain.

show abstract

Relationship between Chronic Pain and Cognition in Cognitively Intact Older Persons and in Patients with Alzheimer’s Disease

Cited by 59 publications

References 92 publications

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

The effect of pain on cognitive function: A review of clinical and preclinical research

Performance-dependent inhibition of pain by an executive working memory task

Contact Info

Product

Resources

About