Relationship between cigarette smoking and radiographic knee osteoarthritis in Chinese population: a cross-sectional study

Abstract

The purpose of this paper was to estimate the cross-sectional association between cigarette smoking and radiographic knee Osteoarthritis (OA) in Chinese population. A total of 3,789 subjects (1,796 females and 1,993 males) participated in this study. A subject was diagnosed with radiographic knee OA if Kellgren-Lawrence (K-L) grade ≥2 in at least one leg. The smoking status was classified into four levels based on the daily smoking habit: (1) 0/day; (2) 1-10/day; (3) 11-20/day; and (4) >20/day. Linear trend and multivariable logistic regression were conducted for statistical analysis. The prevalence of radiographic knee OA was 28.4 % among the subjects of this study. An inverse association was observed between cigarette smoking and radiographic knee OA in the linear trend test. Such association remained valid after adjusting the factors of age, gender, body mass index, betel quilt chewing status, physical activity, alcohol drinking status, mean total energy intake and educational level in the multivariable logistic regression. This study suggested a negative association between cigarette smoking and radiographic knee OA in the Chinese population. The findings of this study need to be confirmed by further prospective research.

Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

“…This cross-sectional study enrolled Chinese members of the general public who were undergoing health screening to explore the association between nutrition and the disease; the study design has been published 15 . This cross-sectional study enrolled Chinese members of the general public who were undergoing health screening to explore the association between nutrition and the disease; the study design has been published 15 .…”

Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis

“…Five studies provided enough data for doseeresponse analysis 13,26,28,57,58 . After evaluating the doseeresponse patterns of cigarettes per day in ever vs never smokers, we observed a linear decrease in knee OA with increasing cigarette consumption.…”

“…The results of previous studies investigating the association between smoking and knee OA have been variable. Some studies found that smoking protected against knee OA 12,13 , while others failed to detect any significant association between them 14,15 . A metaanalysis conducted by Hui et al 16 concluded that previous epidemiological studies are likely to be affected by selection bias, and thus the protective effect of smoking against OA may be false.…”

Association between height and osteoarthritis of the knee and hip: The Northern Finland Birth Cohort 1966 Study

“…Age, body mass index (BMI) and gender are the most investigated and acknowledged risk factors for knee OA . However, there is also evidence of associations between knee OA and ethnicity, physical stress at work, joint injuries, metabolic disturbances and smoking . Age, physical stress at work and joint injuries are known to increase the risk of hip OA.…”

“…[5][6][7] However, there is also evidence of associations between knee OA and ethnicity, 8,9 physical stress at work, 7 joint injuries, 10 metabolic disturbances [11][12][13] and smoking. 14 Age,15 physical stress at work [16][17][18] and joint injuries 17,19 are known to increase the risk of hip OA. There is also evidence of an association between high BMI and hip OA.…”