Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Abstract

AimThe aim of this study was to assess the relationship of circadian syndrome and stroke.MethodsWe performed a cross-sectional analysis of 11,855 participants from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018, and collected the baseline characteristics. Multivariate logistic regression models were developed to explore the association between circadian syndrome and stroke. Simultaneously, subgroup analyses based on the difference of gender, race, and components associated with circadian syndrome also were performed. The odds ratio (OR) and 95% CI were calculated in this study.ResultsAll the participants were divided into the non-stroke group and the stroke group. There were approximately 3.48% patients exclusively with stroke and 19.03% patients exclusively with circadian syndrome in our study. The results suggested that the risk of stroke in patients with circadian syndrome was higher than that in patients without circadian syndrome (OR = 1.322, 95 CI%: 1.020–1.713). Similar associations were found in women with circadian syndrome (OR = 1.515, 95 CI%: 1.086–2.114), non-Hispanic whites with circadian syndrome (OR = 1.544, 95 CI%: 1.124–2.122), participants with circadian syndrome who had elevated waist circumference (OR = 1.395, 95 CI%: 1.070–1.819) or short sleep (OR = 1.763, 95 CI%: 1.033–3.009).ConclusionCircadian syndrome was associated with the risk of stroke. Particularly, we should pay more close attention to the risk of stroke in those populations who were female, non-Hispanic whites, had the symptoms of elevated waist circumference or short sleep.

Association between circadian syndrome and chronic diarrhea: a cross-sectional study of NHANES 2005–2010 data

“…Thus, it should be emphasized that short sleep was included as one of the Circs diagnostic components, and that a single component cannot adequately reflect circadian dysregulation. In our three-model analyses, OR increased with the number of diagnostic elements, consistent with a previous study ( Wang et al, 2022 ), which meant that the number of matching characteristics increased the risk of CD. In future research, the precise quantification of representative elements in Circs may benefit its clinical management.…”

“…For example, Shi et al (2021) and Shi et al (2022 ) reported that Circs had a better predictive value than metabolic syndrome for cardiovascular disease in both Chinese and US adults. Additionally, studies also reported positive Circs associations with stroke ( Wang et al, 2022 ), kidney stones ( Xiao et al, 2023a ), and testosterone deficiency ( Xiao et al, 2023b ).…”

The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018

“…The diagnosis of CircS is established by the presence of at least four chronic conditions, including hypertension, dyslipidemia, increased waist circumference, diabetes, short sleep duration, and depression [ 13 ]. Recent research suggests that CircS may be a more robust predictor of cardiovascular diseases [ 13 , 14 ] and stroke [ 15 ] than MetS alone, thereby underscoring its potential role in increasing the risk of frailty. Additionally, disruption in circadian rhythms can affect cognitive behaviors such as attention, alertness, higher-order executive functions, and memory [ 16 ].…”

Circadian Syndrome Is Associated with Dietary Patterns among Middle-Older Americans: The Health and Retirement Study

“…Previous studies have shown that the magnitude of associations between CircS and the prevalence and incidence of CVDs was higher than the magnitude of associations between MetS and CVDs [ 11 , 12 ]. Also, adults with CircS had higher odds of testosterone deficiency [ 13 ], stroke [ 14 ], and kidney stones [ 15 ] compared to counterparts who did not have CircS.…”