Relationship between circulating irisin levels and overweight/obesity: A meta-analysis

Jia, Junjing; Fan, Yu; Wei, Weiping; Yang, Ping; Zhang, Ren; Sheng, Yue; Shi, Yong-Qin

doi:10.12998/wjcc.v7.i12.1444

Cited by 45 publications

(30 citation statements)

References 39 publications

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“…The results in the present study revealed that there are high significant differences in each BMI, WC, FBS, insulin, HOMA-IR, and HOMA-B 2 between the normal weight group and obese group, suggesting that obesity has a role in impair of glucose-insulin homeostasis. Consistent with the previous study [ 8 , 12 ], there is a significant increase in the irisin level in the obese group compared to the normal weight group. The potential explanation could be because hypersecretion of irisin in the obese group is as a compensatory mechanism to combat irisin resistance in the obese [ 12 , 16 , 17 , 21 ].…”

Section: Discussionsupporting

confidence: 92%

“…FNDC5 is a type I trans-membrane protein which is predominantly present in cardiac and skeletal muscles and is secreted into the blood circulation [ 7 ]. Recently, a meta-analysis study found that the irisin level is higher in obese than normal weight individuals [ 8 ]. It is believed that irisin has a significant role in exercise-induced browning of white adipose tissues and stimulating the metabolic gene expression.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men

Rashid

Abbas²,

Naser

et al. 2020

The Scientific World Journal

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Background. Irisin is a myokine that has a beneficial effect on obesity and glucose metabolism by increasing energy expenditure. This study aims to investigate the effect of long-term moderate physical exercise on irisin levels and its correlations with body mass index (BMI), waist circumferences (WC), and metabolic parameters in normal weight and obese males. Material and method. A follow-up case-control study of sixty male participants, comprised of thirty normal weight and thirty obese, who had undergone supervised long-term moderate physical exercises for six months. Serum irisin levels, fasting blood glucose, serum insulin, homeostatic model assessment of the insulin resistance index (HOMA-IR), and β-cell function (HOMA-B2) were assessed. Results. Long-term moderate exercise induced elevation of the irisin level significantly (P<0.0001) with significant reduction of the BMI, WC, fasting blood glucose, insulin, HOMA-IR, and HOMA-B2 levels (P<0.0001) in comparison between obese and normal weight groups. There are significant differences for each parameter in each obese and normal weight group before and after physical exercise with exception of the BMI and WC in the normal group. Significant negative correlations were shown between irisin and blood glucose and insulin and HOMA-IR levels in the obese group and normal weight group. Conclusion. Irisin improves glucose homeostasis after long-term moderate physical exercises, suggesting that irisin could have regulatory effect on glucose, insulin resistance, and obesity and it could be used as a potential therapy for obesity and insulin resistance.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men

Rashid

Abbas²,

Naser

et al. 2020

The Scientific World Journal

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“…In addition, the included studies were performed in East Asia, India, and Egypt, and the generalizability of the findings is therefore limited. The association between serum irisin and DN in T2DM patients of other ethnicity, such as the Caucasians, should be determined in the future, since a potential ethnicity-difference in serum irisin level has been reported in previous studies including overweight/obesity population [44]. Besides, we chose eGFR of 60 ml/min as the cutoff value since most of the included studies reported the difference in serum irisin levels between DM patients with eGFR < or > 60 ml/min.…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

Wang

Liu

2021

Horm Metab Res

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Irisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes’ Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48–1.77, p<0.001; I2=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93–2.79, p<0.001; I2=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microalbuminuria (10 studies, SMD: 0.91, 95% CI: 0.44–1.38, p<0.001; I2=90%). In addition, patients with estimated glomerular infiltration rate (eGFR)<60 ml/min 1.73 m2 had lower serum irisin compared to those with eGFR≥60 ml/min 1.73 m2 (4 studies, SMD: 0.89, 95% CI: 0.32–1.46, p=0.002; I2=91%). In conclusion, serum irisin may be associated with albuminuria and reduced eGFR in T2DM patients.

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“…I risin -a novel, exercise-induced, myokine produced by proteolytic cleavage of fibronectin type III domain-containing 5 (FNDC5) -is mainly involved in the regulation of energy metabolism by activating thermogenesis to increase energy expenditure (1). In addition, it has been suggested that the myokine might be associated with glucose and lipid metabolism, insulin sensitivity (2), oxidative stress (3), and variations in body weight (4). Some reports demonstrated an association of irisin with systolic (SBP) (5-7) and diastolic (DBP) (5-8) blood pressure, but other yielded conflicting results (9,10).…”

Section: Introductionmentioning

confidence: 99%

Associations of circulating irisin with 24-h blood pressure, total and visceral fat, and metabolic parameters in young adult hypertensives

Miazgowski

Kaczmarkiewicz

et al. 2021

Archives of Endocrinology and Metabolism

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Objective: Some experimental and clinical studies suggest a possible role of irisin in central and peripheral regulation of blood pressure. The purpose of the study was to assess the associations between serum irisin levels, total and visceral fat, metabolic parameters, and blood pressure pattern during 24-h monitoring (ABPM). Materials and methods: In 206 patients with essential hypertension receiving standard antihypertensive treatments, we assessed anthropometric indices; serum irisin, blood lipids (total cholesterol, LDL-C, HDL-C, and triglycerides), glucose and insulin; body composition including lean mass and total, visceral, android and gynoid fat using a dual-energy x-ray absorptiometry; ABPM; and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Results: Baseline irisin levels were within normal reference ranges and comparable between the genders. There were no significant correlations of irisin with age, anthropometric variables, lipids, HOMA-IR, body composition, as well as 24-h blood pressure and dipping status. In univariate analysis, age, fat mass and distribution, lipids and glucose, HOMA-IR, and nocturnal blood pressure fall were poor predictors of irisin levels. These neutral associations were not affected by age, gender, and treatment modality. Conclusions: In young adult hypertensives, serum concentration of irisin was within a normal range and not associated with total and regional fat, blood lipids, insulin resistance, as well as 24-h blood pressure and the magnitude of its nocturnal fall.

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Relationship between circulating irisin levels and overweight/obesity: A meta-analysis

Cited by 45 publications

References 39 publications

Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men

Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

Associations of circulating irisin with 24-h blood pressure, total and visceral fat, and metabolic parameters in young adult hypertensives

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