Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes

Abstract

Background: The protein netrin-1 has demonstrated anti-inflammatory, tissue regeneration, and immune modulation properties. Although inflammation is a major contributing factor in the development of insulin resistance and type 2 diabetes, little is known about a possible relationship between serum netrin-1 and type 2 diabetes. Therefore, we investigated the association between circulating levels of netrin-1 and glycometabolic parameters predictive of type 2 diabetes.Methods: Serum samples were collected from 41 normal controls, 85 subjects with impaired fasting glucose (IFG), and 92 subjects with newly diagnosed type 2 diabetes. Clinical and laboratory parameters were assessed and netrin-1 levels were measured by commercial enzyme-linked immunosorbent assay. Spearman correlation analyses and multivariable-adjusted regression analyses were conducted to examine the relationship between serum netrin-1 levels and glycometabolic parameters.Results: Serum netrin-1 levels in subjects with type 2 diabetes or IFG were significantly higher compared to normal controls (441.0, 436.6, and 275.9 pg/mL, respectively; P for trend < 0.001). Serum netrin-1 levels were significantly positively correlated with fasting glucose, HbA1c, and insulin resistance index (all Ps < 0.01). Serum netrin-1 levels were independently associated with IFG or type 2 diabetes (standardized β = 0.405, P < 0.001) after adjusting for covariates and potential confounders. In addition, the receiver operating characteristic (ROC) analysis showed that serum netrin-1 levels could identify the presence of IFG and type 2 diabetes with the area under the ROC curve (AUC) of 0.784 (P < 0.001).Conclusions: Our results suggest that elevated serum netrin-1 levels are significantly associated with the presence of IFG and type 2 diabetes.

Netrin‐1 and its receptor Unc5b as markers of periodontal disease

“…Liu, et al reported that plasma Netrin‐1 levels were lower in newly diagnosed type 2 diabetes mellitus patients than those in healthy controls and also the levels were negatively correlated with blood glucose levels and insulin resistance. Conversely, increased serum Netrin‐1 concentrations in patients with type 2 diabetes have been reported in recent studies . Our results demonstrated decreased serum Netrin‐1 and Unc5b levels in periodontitis patients and also the levels were negatively correlated with the whole mouth inflammatory clinical parameters.…”

“…Conversely, increased serum Netrin-1 concentrations in patients with type 2 diabetes have been reported in recent studies. 32,33 Our results demonstrated decreased serum Netrin-1…”

Níveis Elevados de Netrina-1 e IL-1β em Mulheres Idosas com SCA: Pior Prognóstico no Acompanhamento de Dois Anos

“…Esse possível aumento pode estar relacionado à maior frequência de fatores de risco cardiovasculares neste grupo no presente estudo, fatores que podem levar a um aumento dos níveis de marcadores inflamatórios. 36 No entanto, mesmo após o ajuste desses fatores, níveis elevados de Netrina 1 e IL-1β permaneceram associados a pior prognóstico, demonstrando que esses marcadores inflamatórios estão independentemente associados a pior prognóstico e podem estar relacionados à redução da capacidade arterial já observada em mulheres idosas, quando comparados aos homens.…”

Protective factors as biomarkers and targets for prevention and treatment of diabetic nephropathy: From current human evidence to future possibilities

“…The anti-oxidant factors were previously reported in the context of DKD, although mainly in functional or small cross-sectional studies [49][50][51][52][53] . In addition, investigation of other protective factors in diabetes patients, such as growth factors, adenosine, immune proteins, fibroblast growth factor receptors and netrins, is in early stages [54][55][56][57][58][59][60][61] .…”