Relationship Between Circulating Plasma Matrix Metalloproteinase-9 (gelatinase-B) Concentration and Aortic Root Dilatation

Karakaya, Osman; Barutçu, İrfan; Esen, Ali Metin; Doğan, Serkan; Sağlam, Mustafa; Karapınar, Hekim; Akgün, Taylan; Karaveli̇oğlu, Yusuf; Esen, Özlem; Özdemir, Nihal

doi:10.1016/j.amjhyper.2005.08.013

Cited by 28 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Continued excessive MMP-9 production and activation result in increased degradation of aortic wall elastin rather than an increase in its synthesis, with alteration of the mechanical properties of the aortic wall, leading to elevated large arterial stiffness. Our finding that the MMP-9 level is increased and positively correlated with CFPWV in hypertensive patients is in accord with the literature and is consistent with the evidence implying that the composition of the extracellular matrix plays an important role in genesis of vascular changes in hypertension (10,11).…”

Section: Discussionsupporting

confidence: 82%

Impact of the Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 System on Large Arterial Stiffness in Patients with Essential Hypertension

et al. 2007

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Impact of the Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 System on Large Arterial Stiffness in Patients with Essential Hypertension

et al. 2007

View full text Add to dashboard Cite

“…The largest diameter of all measurements was accepted as the aortic root dilatation. The aorta root was defined as dilated when it measured ≥38 mm [11]. …”

Section: Methodsmentioning

confidence: 99%

Diabetes Mellitus: Is It Protective against Aortic Root Dilatation?

et al. 2008

View full text Add to dashboard Cite

Objectives: There is evidence of a negative association between diabetes and both abdominal aortic aneurysm and aortic diameter. However, little information is available on the relation between diabetes and aortic root diameter. Methods: We studied 109 patients with type 2 diabetes. Two-dimensional echocardiography was used to measure the aortic root at the aortic annulus, the sinus of Valsalva, the sinotubular junction and the proximal part of the ascending aorta. Measured mean values were compared with 218 age- and sex-matched patients without diabetes. A comparison of the prevalence of aortic regurgitation between the 2 groups was also performed. Results: In patients with diabetes, the mean aortic root dimensions were significantly smaller than in nondiabetic patients (p < 0.05). The prevalence of aortic root dilatation was significantly higher in nondiabetic subjects than in patients with diabetes (9.63 vs. 2.75%; p = 0.025). In the multivariable regression model, diabetes was a significant negative determinant of aortic root size at all measured sites. The prevalence of aortic regurgitation tended to be higher in nondiabetic subjects than in diabetic participants (11 vs. 18.8%); however, the difference did not achieve statistical significance (p = 0.071). Conclusions: In patients with diabetes, the aortic root dimension is significantly smaller than in patients without diabetes.

show abstract

“…The correlation coefficient for aortic root diameters was 0.95-0.98. The aorta root was defined as dilated when its diameter was measured ≥ 38 mm (Karakaya et al, 2006).…”

Section: Ultrasound Evaluationmentioning

confidence: 99%

Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

Tang

Jiang

Chen

et al. 2010

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: Uric acid (UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome (MS). This study aims to investigate the relation between UA levels and aortic root dilatation. Methods: A total of 348 hypertensive patients [age (67.5±9.8) years] with or without MS were included in the study. The aortic root diameters at the aortic annulus, the sinuses of Valsalva, the sinotubular junction, and the proximal part of the ascending aorta were measured using a two-dimensional (2D) echocardiography. Serum UA levels were also measured for all patients. Results: A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva (P=0.001) and the proximal ascending aorta (P<0.0001) in the hypertensive patients without MS. In contrast, aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS. Furthermore, increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS (sex-adjusted hazard ratio 1.75, 95% confidence intervals (CI) 1.27-2.41), but not in those with MS. Conclusions: This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS. Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.

show abstract

Relationship Between Circulating Plasma Matrix Metalloproteinase-9 (gelatinase-B) Concentration and Aortic Root Dilatation

Cited by 28 publications

References 25 publications

Impact of the Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 System on Large Arterial Stiffness in Patients with Essential Hypertension

Impact of the Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 System on Large Arterial Stiffness in Patients with Essential Hypertension

Diabetes Mellitus: Is It Protective against Aortic Root Dilatation?

Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

Contact Info

Product

Resources

About