Relationship between circulating VCAM-1, ICAM-1, E-selectin and MMP9 and the extent of coronary lesions

Abstract

OBJECTIVES:Inflammatory molecules play a role in the development of atherosclerosis, which is the primary origin of cardiovascular disorders. However, to the best of our knowledge, no study has attempted to investigate the relationship between these circulating molecules and the prediction of cardiovascular risk. The present study aimed to investigate the relationships of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and matrix metalloproteinase 9 serum concentrations with the extent of coronary lesions.METHODS:Seventy-four individuals who were undergoing coronary angiography for the first time for diagnostic purposes were enrolled in this study. The extent of the coronary lesion was assessed using the Friesinger Index, and subjects were classified into four groups: no lesions, minor lesions, intermediate lesions and major lesions. Serum biochemical parameters and serum concentrations of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and matrix metalloproteinase 9 were analyzed.RESULTS:The vascular cell adhesion molecule-1 concentration was higher than 876 ng/mL in individuals with intermediate and major lesions (p<0.001 and p=0.020, respectively). Moreover, logistic regression analysis showed that these patients had an increased risk of having an intermediate lesion (p=0.007). Interestingly, all individuals with major lesions had vascular cell adhesion molecule-1 concentrations higher than 876 ng/mL. No association was found between the concentrations of the other proteins and the Friesinger Index.CONCLUSIONS:Serum vascular cell adhesion molecule-1 may be associated with the extent of coronary lesions. Moreover, it may represent an alternative to improve the cardiovascular risk classification in patients without acute coronary syndrome.

Resveratrol prevents TNF-α-induced VCAM-1 and ICAM-1 upregulation in endothelial progenitor cells via reduction of NF-κB activation

“…The primary cause of CAD is atherosclerosis, a chronic inflammatory process in which adhesion molecules are upregulated at the endothelial membrane. 7 Adhesion molecules including VCAM-1, ICAM-1 and E-selectin induce the adhesion of leukocytes as well as their migration into the intima. 7 EC VCAM-1 represents a pro-atherogenic adhesion molecule essential for both atherosclerosis initiation and progression to plaque instability.…”

“… 7 Adhesion molecules including VCAM-1, ICAM-1 and E-selectin induce the adhesion of leukocytes as well as their migration into the intima. 7 EC VCAM-1 represents a pro-atherogenic adhesion molecule essential for both atherosclerosis initiation and progression to plaque instability. 23 Serum VCAM-1 levels likely control the degree of coronary injury.…”

“… 23 Serum VCAM-1 levels likely control the degree of coronary injury. 7 Patients with intermediate and major lesions tend to have high VCAM-1 concentrations. 7 VCAM-1 levels on ECs are directly correlated with inflammation during myocardial infarction.…”

“… 7 Patients with intermediate and major lesions tend to have high VCAM-1 concentrations. 7 VCAM-1 levels on ECs are directly correlated with inflammation during myocardial infarction. 24 In addition to atherosclerotic plaque formation, adhesion molecules might also be involved in the generation of restenotic neointima.…”

Up-regulated lncRNA-PVT1 Expression in Peripheral Blood Mononuclear Cells of Patients with Coronary Artery Disease is Correlated with Decreased Interleukin-10 Production

“…Therefore, MMP-9 can be evaluated in several clinical situations in which in ammation is an underlying contributor, e.g. CAD (8).…”