Relationship Between Collagen-induced and Adjuvant Arthritis in the Lewis Rat

Hunt, David W. C.; Corson, L.; Barker, H.; Levy, J G; Petty, Ross E.

doi:10.1006/jaut.1993.1058

Cited by 7 publications

(2 citation statements)

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“…In the animal model, symptoms of disease were only inducible by immunization with the respective peptides in complete Freund's adjuvant (CFA), while adjuvant induced arthritis was observed only in very rare cases (about 3 %) of rats immunized with other antigens in CFA or CFA alone, indicating that the arthritis was caused by specific immune reactions to these peptide antigens. Immunization of Lewis rats with arthritogenic peptides in incomplete Freund's adjuvant (IFA) was not performed, since immunization of Lewis rats with autoantigen in IFA does not cause autoimmune diseases 25. In our hands, rats never developed uveitis after injection of retinal S‐Antigen peptide in IFA (unpublished observations).…”

Section: Discussionmentioning

confidence: 66%

Induction of arthritis and uveitis in Lewis rats by antigenic mimicry of peptides from HLA-B27 and cytokeratin

2002

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Ankylosing spondylitis (AS) is highly associated with HLA‐B27. We have previously shown that peripheral blood lymphocytes from AS patients respond to stimulation with a peptide from the sequence of HLA‐B27. Here we report on molecular mimicry of peptides from HLA‐B27 and cytokeratin, the latter being specifically expressed in synovial membranes and eyes, the main targets of the autoaggressive immune response in AS patients. Immunization of rats with these peptides induced an inflammatory response in joints, spine and eyes, resembling the symptoms in AS. Furthermore, both HLA‐B27‐ and cytokeratin‐derived peptides, are effective oral tolerogens: feeding these peptides ameliorated arthritis and uveitis induced with the cytokeratin peptide. Our model might elucidate the role of peptides from the sequence of HLA‐B27 as an antigen of the immune response in AS, introducing a new aspect of antigenic mimicry between HLA‐B27 and tissue‐specific antigens. We propose this as a mechanism directing a systemic autoimmune response to specific target organs by antigenic mimicry of T cell epitopes.

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Section: Discussionmentioning

confidence: 66%

Induction of arthritis and uveitis in Lewis rats by antigenic mimicry of peptides from HLA-B27 and cytokeratin

2002

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“…The above findings prompted us to investigate whether specific peptides of HSP60 might activate lymphocyte responses, as has been found in other autoimmune diseases (Hunt et al 1993, Anderton et al 1995, Elias et al 1995. Thirty-eight peptide fragments of human HSP60, each of 18-21 amino acids, were assayed for lymphocyte stimulation.…”

Section: Resultsmentioning

confidence: 96%

Elevated Cellular Immune Response to Human Heat-Shock Protein-60 in Schizophrenic Patients

Leykin¹,

Spivak²,

Weizman

et al. 1999

European Archives of Psychiatry and Clinical Neurosciences

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Heat shock protein-60 (HSP60) is implicated in several autoimmune diseases as a triggering antigen. Based on the autoimmune hypothesis of schizophrenia, we examined cellular and humoral responses against HSP60 and a series of its peptide fragments with peripheral blood samples of schizophrenic patients and healthy subjects each of group size between 12 to 32 participants. The average stimulation indices of peripheral blood mononuclear cells (PBMC) to HSP60 were 3.17 +/- 0.36 (mean +/- SE) for schizophrenic patients and 2.23 +/- 0.24 (mean +/- SE) for healthy subjects, with a significant difference between the groups (P = 0.0457). In parallel, 38 synthetic peptide fragments of HSP60, each of 18-21 amino acids, were tested for in vitro sensitization of PBMC. With one peptide (p32) the average stimulation index of PBMC from schizophrenic patients was significantly higher than that obtained for PBMC of control subjects (P = 0.0006). Comparing the cellular immune response to p32 between patients who were distinctive responders (n = 10) or non-responders (n = 10) to neuroleptic treatment indicated a similar elevation of cellular response in these groups. Antibodies against HSP60 were screened by dot-blot and ELISA in the sera of the above blood samples. Titers of IgG and IgM against HSP60 were found to be of similar magnitude in schizophrenic patients and in controls. Titers of IgA against HSP60 were somewhat higher in the sera of schizophrenic patients in comparison to sera of control subjects (P = 0.0605).

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Adjuvant Arthritis

Cohen

1998

Encyclopedia of Immunology

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Relationship Between Collagen-induced and Adjuvant Arthritis in the Lewis Rat

Cited by 7 publications

References 0 publications

Induction of arthritis and uveitis in Lewis rats by antigenic mimicry of peptides from HLA-B27 and cytokeratin

Induction of arthritis and uveitis in Lewis rats by antigenic mimicry of peptides from HLA-B27 and cytokeratin

Elevated Cellular Immune Response to Human Heat-Shock Protein-60 in Schizophrenic Patients

Adjuvant Arthritis

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