Relationship between Condylomata and Laryngeal Papillomata

Abstract

In a survey of 49 papilloma patients accurate maternal condyloma history was obtained in 31 instances and of these, 21 were positive for the presence of condyloma during pregnancy or parturition. Molecular virological studies indicate that positive hybridization could be demonstrated to human papilloma virus 2 in both laryngeal papilloma and condyloma by the Southern blot technique. Immunoperoxidase staining illustrated the presence of virus-related particles only near the surface of the mucous membrane papilloma, which is in contrast to the definite staining of the stratum granulosum and stratum corneum of verrucae. Collectively this provides convincing evidence for an etiological relationship between condyloma acuminata and some laryngeal papillomata. The highly contagious nature of human papilloma virus infection is discussed and the possibility of cesarian section in the presence of active condyloma must be considered.

Human Papillomavirus Infections in Children: the Potential Role of Maternal Transmission

“…The full extent of the complex problems posed by genital warts in small children was fully appreciated only in the early 1990s. Crit Rev Oral Biol Med ic assessment of other sexually transmitted diseases (STDs), and (4) age-adjusted interviews of the child and caretakers by skilled personnel (Gutman et al, 1992(Gutman et al, , 1994 (Cook et al, 1973;Strong et al, 1976;Quick et al, 1980;Hallden and Majmudar, 1986;Abramson et al, 1987). Recently, a case of laryngeal papilloma was reported in a one-year-old child delivered vaginally (Alberico et al, 1995).…”

“…AOP patients reported more lifetime sexual partners and a higher frequency of oral sex than adult controls. A maternal history of genital condyloma at the time of delivery or during pregnancy among RRP patients has been reported to vary from 54% to 67% (Cook et al, 1973;Quick et al, 1980;Hallden and Majmudar, 1986). In a series of 109 JOP patients, only one child was delivered by Caesarean section .…”

The HPV Vaccine Controversy

“…Finally, research indicates that nonsexual modes of HPV transmission include perinatal transmission from an infected mother [53]. Vertical transmission of the virus occurs primarily during vaginal delivery [54], but HPV can also infect infants delivered by caesarean section [55] and can be transmitted transplacentally to the fetus [56].…”

Nosocomial Sexuall Transmitted Disease

“…Babies born to mothers with genital warts have, however, been noted to develop laryngeal papillomata, and some workers, believing that the papilloma virus may be acquired during the birth process, have suggested that extensive vaginal venereal warts may be an indication for delivery by Cesarean section. 34 Babies born to mothers with venereal warts need not be subject to special isolation in the nursery, nor need one take special precautions concerning rooming-in.…”