Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography

Vu, Daniel M.; Silva, Fabiana Q.; Haseltine, Sarah J.; Ehrlich, Joshua R.; Radcliffe, Nathan M.

doi:10.1007/s00417-013-2311-x

Cited by 29 publications

(28 citation statements)

References 26 publications

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“…After adjusting for CCT, age, and axial length, corneal hysteresis was not associated with RNFL thickness measured by either polarimetry or spectral-domain optical coherence tomography. Vu et al [ 27 ▪ ] conducted a retrospective study of 131 patients with glaucoma. In a univariable model, corneal hysteresis varied as a function of mean deviation and spectral-domain optical coherence tomography RNFL thickness ( β = 0.2, P = 0.001); after multivariable analysis, however, the relationship between corneal hysteresis and RNFL did not hold.…”

Section: Corneal Hysteresis and Structural Markers Of Glaucomamentioning

confidence: 99%

Corneal hysteresis and its relevance to glaucoma

Deol

Taylor

Radcliffe

2015

Current Opinion in Ophthalmology

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108

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Purpose of reviewGlaucoma is a leading cause of irreversible blindness worldwide. It is estimated that roughly 60.5 million people had glaucoma in 2010 and that this number is increasing. Many patients continue to lose vision despite apparent disease control according to traditional risk factors. The purpose of this review is to discuss the recent findings with regard to corneal hysteresis, a variable that is thought to be associated with the risk and progression of glaucoma.Recent findingsLow corneal hysteresis is associated with optic nerve and visual field damage in glaucoma and the risk of structural and functional glaucoma progression. In addition, hysteresis may enhance intraocular pressure (IOP) interpretation: low corneal hysteresis is associated with a larger magnitude of IOP reduction following various glaucoma therapies. Corneal hysteresis is dynamic and may increase in eyes after IOP-lowering interventions are implemented.SummaryIt is widely accepted that central corneal thickness is a predictive factor for the risk of glaucoma progression. Recent evidence shows that corneal hysteresis also provides valuable information for several aspects of glaucoma management. In fact, corneal hysteresis may be more strongly associated with glaucoma presence, risk of progression, and effectiveness of glaucoma treatments than central corneal thickness.

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Section: Corneal Hysteresis and Structural Markers Of Glaucomamentioning

confidence: 99%

Corneal hysteresis and its relevance to glaucoma

Deol

Taylor

Radcliffe

2015

Current Opinion in Ophthalmology

Self Cite

108

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“…[15][16][17] We noted only modest Pearson correlations (À0.15 to À0.20) between CRF and VCDR (clinical and HRT) in our subjects. Although Vu et al 18 showed similar weak associations (r ¼ À0.11 to À0.15) of VCDR with CH, they did not report on the association with CRF. Likewise, Prata et al 19 demonstrated significant correlations with mean cup depth (r ¼ À0.34) and linear cup-disc ratio (r ¼ À0.41) in their evaluation of 42 newly diagnosed POAG patients.…”

Section: Discussionmentioning

confidence: 85%

“…Our study comprised exclusively of subjects with established glaucoma unlike the previous published studies that have included a wider range of subjects encompassing glaucoma suspects and established glaucoma. 7,14,15,18 The wider spectrum in those studies could have resulted in a higher disposition toward an association with disease severity. Therefore, it is likely that an inclusion of angle closure subjects with no evidence of optic neuropathy, such as primary angle closure suspects (PACS) and primary angle closure (PAC), may tilt our findings toward significant associations; however, the primary purpose of our study was to investigate the association of corneal biomechanical properties in PACG subjects with established optic nerve head damage.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma

Nongpiur

Png

Chiew

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Citation: Nongpiur ME, Png O, Chiew JW, et al. Lack of association between corneal hysteresis and corneal resistance factor with glaucoma severity in primary angle closure glaucoma. Invest Ophthalmol Vis Sci. 2015;56:6879-6885. DOI:10.1167/ iovs.15-17930 PURPOSE. We investigated the association between corneal hysteresis (CH) and corneal resistance factor (CRF) with glaucoma severity in primary angle closure glaucoma (PACG). METHODS.We recruited 204 subjects with PACG. Each subject underwent CH and CRF measurements using the Ocular Response Analyzer (ORA), optic nerve head topography measurement using scanning laser ophthalmoscopy, and visual field assessment. Glaucoma severity was based on the visual field mean deviation (MD) and classified as mild (71), moderate (55), and severe (78).RESULTS. The mean age 6 SD of study subjects was 68.7 6 8.9 years, with most being Chinese (n ¼ 186; 91.2%). Corneal hysteresis and CRF were lowest in the severe PACG group (9.32 6 1.86 and 9.50 6 1.67 mm Hg) followed by moderate PACG (9.38 6 1.88 and 9.73 6 1.88 mm Hg) and mild PACG (9.47 6 1.90 and 9.85 6 1.75 mm Hg) respectively, but the differences were not significant (P ¼ 0.89 and P ¼ 0.46, respectively). There was a significant positive correlation between CH and central corneal thickness (CCT; correlation coefficient [r] ¼ 0.26, P < 0.001), CRF and CCT (r ¼ 0.43, P < 0.001), and negative correlation between CRF and vertical cup-disc ratio (VCDR; r ¼ À0.20, P ¼ 0.004), and CRF with cup-disc area (r ¼ À0.14, P ¼ 0.04). Corneal hysteresis and CRF were not correlated with MD (r ¼ 0.01 for CH, r ¼ 0.1 for CRF). After multivariate analyses, adjusting for age, sex, CCT, axial length, intraocular pressure, and number of glaucoma medication, no significant associations were noted between CH and CRF with MD, VCDR, disc area, rim area, or cup area.CONCLUSIONS. Corneal biomechanical parameters measured by the ORA are not associated with severity of glaucoma in PACG.

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“…Our results indicate that the modulus of cornea and sclera can be measured non-invasively and non-destructively using vibrational OCT. This will assist clinicians to better understand the influence of biomechanics on the outcome of refractive surgery [25] and some common eye diseases such as glaucoma [26]- [32], myopia [33], and keratoconus [34] [35] [36]. It has been observed that the modulus of keratoconus corneas is lower than that of normal tissue [7] and that scleral stiffening occurs in glaucoma [37] associated with increased collagen alignment and birefringence [38].…”

Section: Resultsmentioning

confidence: 99%

Non-Invasive and Non-Destructive Determination of Corneal and Scleral Biomechanics Using Vibrational Optical Coherence Tomography: Preliminary Observations

Silver¹,

Shah²,

Benedetto³

2018

MSA

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Experimental measurements made in this study on human and porcine eyes suggest that the resonant frequency for both cornea and sclera varies from 130 to 150 Hz and increases slightly with increasing intraocular pressure. The values of the moduli calculated using the experimental values of the thickness are close to 2 MPa. Similar values of the modulus for cornea and sclera suggest that there is very little stress concentration at the cornea-scleral junction and that any stress concentration that occurs probably resides at the scleral attachment laterally and posteriorly. These moduli are close to those measured in vivo on human skin suggesting that the mechanism of tensile deformation of skin, cornea and sclera are similar. Our results suggest that the modulus of cornea and sclera can be measured non-invasively and non-destructively using vibrational OCT. Results of these studies will assist clinicians to better understand the influence of biomechanics on the outcome of corneal refractive surgery as well as the pathogenesis of eye disorders such as glaucoma, myopia and keratoconus.

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Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography

Abstract: In patients under evaluation and treatment for glaucoma, CH was more closely related to visual field MD than to structural markers of glaucoma damage as measured by SD-OCT.

Cited by 29 publications

References 26 publications

Corneal hysteresis and its relevance to glaucoma

Corneal hysteresis and its relevance to glaucoma

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma

Non-Invasive and Non-Destructive Determination of Corneal and Scleral Biomechanics Using Vibrational Optical Coherence Tomography: Preliminary Observations

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