Relationship between coronary arterial 18F-sodium fluoride uptake and epicardial adipose tissue analyzed using computed tomography

Kitagawa, Toshiro; Nakamoto, Yumiko; Fujii, Yoshiaki; Sasaki, Ko; Tatsugami, Fuminari; Awai, Kazuo; Hirokawa, Yutaka; Kihara, Yasuki

doi:10.1007/s00259-019-04675-z

Cited by 13 publications

(32 citation statements)

References 28 publications

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“…We found 35 eligible articles. Three on the aortic valve ( n = 3) and seven on methodology ( n = 7) were excluded based on the abovementioned criteria, leaving 25 dealing with the coronary arteries [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], femoral artery [ 12 , 13 , 14 , 15 ], abdominal aorta [ 16 , 17 , 18 ], carotid arteries [ 19 , 20 ], thoracic aorta [ 21 ], and intracranial [ 22 ], renal [ 23 ], and penile arteries [ 24 ]. One study focused on the carotid and cerebral arteries [ 25 ], another on the carotids, the aortic arch, and coronary arteries [ 26 ], and a third on several major arteries [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study focused on the carotid and cerebral arteries [ 25 ], another on the carotids, the aortic arch, and coronary arteries [ 26 ], and a third on several major arteries [ 27 ]. Below (and in Supplementary Materials Tables S1–S5 ), the literature is summarized in six sections before being debated in the discussion: Disease mechanisms and targeting [ 10 ], Early detection and prevalence of NaF uptake in the heart and major arteries [ 5 , 23 , 24 , 25 , 27 ], NaF uptake in vulnerable, high risk, and ruptured plaque [ 6 , 7 , 8 , 9 , 19 , 20 ], Influence of age, sex, and other factors on NaF uptake [ 3 , 16 , 22 ], Association between NaF uptake and cardiovascular risk factors [ 4 , 15 , 21 ], NaF uptake and disease progression [ 11 , 12 , 13 , 14 , 17 , 18 , 26 ]. …”

Section: Resultsmentioning

confidence: 99%

“…TBR was in general about 50% higher in lesions with low attenuation than in those without [ 7 ]. Kitagawa et al demonstrated in 40 patients undergoing cardiac CT for suspected coronary artery disease that peri-lesional epicardial adipose tissue was positively associated with coronary TBRmax [ 8 ]. Finally, in an ex vivo study of two samples per nine autopsied patients and a total of 101 coronary plaques, Youn et al demonstrated three times as high NaF uptake in plaques with compared to without microcalcification.…”

Section: Resultsmentioning

confidence: 99%

“…Among adverse plaque features, low attenuation had a sensitivity of 39% and a specificity of 98% for predicting NaF uptake, but positive NaF uptake was often seen in the absence of low attenuation plaque [ 6 , 7 ]. Finally, Kitagawa et al found that perilesional epicardial adipose tissue density correlated positively with cardiac NaF TBRmax in patients with known or suspected CVD, even if the volume of epicardial adipose tissue was similar in patients with coronary arterial uptake above and below their TBR cut-off [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Atherosclerosis Imaging with 18F-Sodium Fluoride PET

et al. 2020

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The evidence on atherosclerosis imaging with 18F-sodium-fluoride (NaF) positron emission tomography (PET) is hotly debated because of the different patient characteristics, methodology, vascular beds, etc. in reported studies. This review is a continuation of a previous review on this topic, which covered the period 2010–2018. The purpose was to examine whether some of the most important questions that the previous review had left open had been elucidated by the most recent literature. Using principles of a systematic review, we ended analyzing 25 articles dealing with the carotids, coronary arteries, aorta, femoral, intracranial, renal, and penile arteries. The knowledge thus far can be summarized as follows: by targeting active arterial microcalcification, NaF uptake is considered a marker of early stage atherosclerosis, is age-dependent, and consistently associated with cardiovascular risk. Longitudinal studies on NaF uptake, conducted in the abdominal aorta only, showed unchanged uptake in postmenopausal women for nearly four years and varying uptake in prostate cancer patients over 1.5 years, despite constant or increasing calcium volume detected by computed tomography (CT). Thus, uncertainty remains about the transition from active arterial wall calcification marked by increased NaF uptake to less active or consolidated calcification detected by CT. The question of whether early-phase atherosclerosis and calcification can be modified remains also unanswered due to lack of intervention studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Atherosclerosis Imaging with 18F-Sodium Fluoride PET

et al. 2020

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“…In 40 patients with more than 1 CT-detectable coronary plaque, perilesional EAT density was correlated with higher Na[ 18 F]F uptake. 75 These results imply that Na[ 18 F]F PET provides insights into the association between perivascular fat and atherosclerosis.…”

Section: Na[ 18 F]f Pet Imaging Of Microcalcificatmentioning

confidence: 89%

An Update on [¹⁸F]Fluoride PET Imaging for Atherosclerotic Disease

Lee

Seok

2020

J Lipid Atheroscler

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Atherosclerosis is the leading cause of life-threatening morbidity and mortality, as the rupture of atherosclerotic plaques leads to critical atherothrombotic events such as myocardial infarction and ischemic stroke, which are the 2 most common causes of death worldwide. Vascular calcification is a complicated pathological process involved in atherosclerosis, and microcalcifications are presumed to increase the likelihood of plaque rupture. Despite many efforts to develop novel non-invasive diagnostic modalities, diagnostic techniques are still limited, especially before symptomatic presentation. From this point of view, vulnerable plaques are a direct target of atherosclerosis imaging. Anatomic imaging modalities have the limitation of only visualizing macroscopic structural changes, which occurs in later stages of disease, while molecular imaging modalities are able to detect microscopic processes and microcalcifications, which occur early in the disease process. Na[ 18 F]-fluoride positron emission tomography/computed tomography could allow the early detection of plaque instability, which is deemed to be a primary goal in the prevention of cardiac or brain ischemic events, by quantifying the microcalcifications within vulnerable plaques and evaluating the atherosclerotic disease burden.

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Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives

Woerden

Veldhuisen

Westenbrink

et al. 2022

European J of Heart Fail

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Obesity is very common in patients with heart failure with preserved ejection fraction (HFpEF) and it has been suggested that obesity plays an important role in the pathophysiology of this disease. While body mass index defines the presence of obesity, this measure provides limited information on visceral adiposity, which is probably more relevant in the pathophysiology of HFpEF. Epicardial adipose tissue is the visceral fat situated directly adjacent to the heart and recent data demonstrate that accumulation of epicardial adipose tissue is associated with the onset, symptomatology and outcome of HFpEF. However, the mechanisms by which epicardial adipose tissue may be involved in HFpEF remain unclear. It is also questioned whether epicardial adipose tissue may be a specific target for therapy for this disease. In the present review, we describe the physiology of epicardial adipose tissue and the pathophysiological transformation of epicardial adipose tissue in response to chronic inflammatory diseases, and we postulate conceptual mechanisms on how epicardial adipose tissue may be involved in HFpEF pathophysiology. Lastly, we outline potential treatment strategies, knowledge gaps and directions for further research.

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Relationship between coronary arterial 18F-sodium fluoride uptake and epicardial adipose tissue analyzed using computed tomography

Cited by 13 publications

References 28 publications

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

An Update on [¹⁸F]Fluoride PET Imaging for Atherosclerotic Disease

Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives

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Relationship between coronary arterial 18F-sodium fluoride uptake and epicardial adipose tissue analyzed using computed tomography

Cited by 13 publications

References 28 publications

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

An Update on [18F]Fluoride PET Imaging for Atherosclerotic Disease

Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives

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An Update on [¹⁸F]Fluoride PET Imaging for Atherosclerotic Disease