Relationship between coronary artery calcium score and bleeding events after percutaneous coronary intervention in chronic coronary syndrome

Komaki, Soichi; Ishii, Masanobu; Kaichi, Ryota; Takae, Masafumi; Mōri, Takayuki; Toida, Reiko; Kurogi, Kazumasa; Matsuura, Yukiko; Yamamoto, Nobuyasu; Tsujita, Kenichi; Tsuruda, Toshihiro; Kaikita, Koichi

doi:10.1007/s00380-023-02248-7

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…In fact, our current study showed a higher occurrence of gastrointestinal bleeding events in patients with CLTI. In the field of coronary artery research, a recent study demonstrated a significant association between a high calcium score and bleeding events 16) .…”

Section: Discussionmentioning

confidence: 99%

Chronic Limb-Threatening Ischemia is a Residual Bleeding Risk Factor among Patients with Lower Extremity Artery Disease

Tokuda,

Yoshioka,

Koyama

et al. 2024

JAT

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Aim: Lower-extremity artery disease (LEAD) is a high-risk factor for bleeding. However, the specific risk factors for bleeding in patients with LEAD remain unclear. We aimed to identify risk factors for bleeding in patients with LEAD after endovascular treatment (EVT). Methods: This multicenter, retrospective, observational study included 732 consecutive patients with LEAD who underwent EVT between January 2018 and December 2019. Patient characteristics, laboratory data, target lesions, and medications were compared between patients with and without chronic limb-threatening ischemia (CLTI). Predictive bleeding risk factors were explored using Cox regression analysis with differential models. Results: In model 1, a body mass index (BMI) ＜18.5 kg/m 2 , prior heart failure, high bleeding risk, use of single antiplatelet therapy (SAPT) plus warfarin, and CLTI were predictive bleeding risk factors (hazard ratio [HR] 2.05; 95% confidence interval [CI] 1.13-3.52; p ＜0.01; HR 2.15; 95% CI 1.28-3.55; p ＜0.01; HR 3.40; 95% CI 1.28-3.55; p ＜0.01; HR 2.05; 95% CI 1.33-5.84; p ＜0.01; respectively). In model 2, a BMI ＜18.5 kg/m 2 , prior heart failure, anemia (＜11 g/dL), low platelet count (＜10*10 4 /µL), chronic kidney disease, use of single antiplatelet therapy (SAPT) plus warfarin, and CLTI were independent risk factors for bleeding (model 2: HR 2.05; 95% CI 1.12-3.56; p =0.02; HR 2.35; 95% CI 1.39–3.90; p ＜0.01; HR 2.71; 95% CI 1.64–4.50; p ＜0.01; HR 2.66; 95% CI 1.00–5.89; p =0.05; HR 2.47; 95% CI 1.25–5.45; p ＜0.01; HR 2.79; 95% CI 1.24-5.63; p =0.01; respectively) Conclusions: CLTI is a residual and predictive risk factor for bleeding in patients with LEAD. We have to pay attention to the bleeding events of patients with CLTI after EVT during follow-up.

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Section: Discussionmentioning

confidence: 99%

Chronic Limb-Threatening Ischemia is a Residual Bleeding Risk Factor among Patients with Lower Extremity Artery Disease

Tokuda,

Yoshioka,

Koyama

et al. 2024

JAT

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“…In particular, AF patients are at greater risk than SR patients. This is because the study targets patients with severe CAC, which requires RA, but AF patients generally have higher CAC scores [34], associated with complications such as bleeding and periprocedural MI [35,36], compared to SR patients. The present study also showed the same trend.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Atrial Fibrillation in Patients with Heavily Calcified Coronary Artery Disease Receiving Rotational Atherectomy

Jung,

Seo,

Her

et al. 2023

Medicina

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Background and Objectives: Although both rotational atherectomy (RA) and atrial fibrillation (AF) have a high thrombotic risk, there have been no previous studies on the prognostic impact of AF in patients who undergo percutaneous coronary intervention (PCI) using RA. Thus, the aim of the present study was to determine the prognostic impact of AF in patients undergoing PCI using RA. Materials and Methods: A total of 540 patients who received PCI using RA were enrolled between January 2010 and October 2019. Patients were divided into AF and sinus rhythm groups according to the presence of AF. The primary endpoint was net adverse clinical events (NACEs) defined as a composite outcome of all-cause death, myocardial infarction, target vessel revascularization, cerebrovascular accident, or total bleeding. Results: Although in-hospital adverse events showed no difference between those with AF and those without AF (in-hospital events, 54 (11.0%) vs. 6 (12.2%), p = 0.791), AF was strongly associated with an increased risk of NACE at 3 years (NACE: hazard ratio, 1.880; 95% confidence interval, 1.096–3.227; p = 0.022). Conclusions: AF in patients who underwent PCI using RA was strongly associated with poor clinical outcomes. Thus, more attention should be paid to thrombotic and bleeding risks.

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Relationship between coronary artery calcium score and bleeding events after percutaneous coronary intervention in chronic coronary syndrome

Cited by 2 publications

References 24 publications

Chronic Limb-Threatening Ischemia is a Residual Bleeding Risk Factor among Patients with Lower Extremity Artery Disease

Chronic Limb-Threatening Ischemia is a Residual Bleeding Risk Factor among Patients with Lower Extremity Artery Disease

Prognostic Impact of Atrial Fibrillation in Patients with Heavily Calcified Coronary Artery Disease Receiving Rotational Atherectomy

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