Relationship Between Crevicular Aspartate Aminotransferase Levels and Periodontal Disease Progression

Oringer, Richard J.; Howell, T. Howard; Nevins, M; Reasner, David S.; Davis, G. H. G.; Sekler, J; Fiorellini, Joseph P.

doi:10.1902/jop.2001.72.1.17

Cited by 28 publications

(21 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cells release AST into the extracellular space during periods of tissue necrosis or trauma, resulting in a detectable enzyme quantity in the peripheral circulation. Higher levels of AST are found in the GCF of diseased sites than in healthy sites, and have been reported as a possible marker of periodontally active sites (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Significant AST levels have also been found in human gingival epithelial cells, human gingival fibroblasts and human periodontal ligament fibroblasts (14).…”

Section: Introductionmentioning

confidence: 99%

Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Silva

Salvador

Fogo

et al. 2003

Journal of Oral Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Silva

Salvador

Fogo

et al. 2003

Journal of Oral Science

View full text Add to dashboard Cite

“…The characteristics of the selected trials are summarised below (see also Table 3). In terms of experimental design, the majority [17][18][19][20][21][22][23][24][25][26][27][28][29] were conventional parallel trials with either two or three treatment arms. In addition, there were some [30][31][32] split-mouth trials.…”

Section: Resultsmentioning

confidence: 99%

“…The other 33,34 trials employed crossover designs. All trials except for three 23,27,32 stated that some form of randomisation was employed. …”

Section: Resultsmentioning

confidence: 99%

“…The other trials in this review employed p-value-corrected interim analyses (four trials), 18,22,24,28 sequential treatment allocation (five trials) 17,20,21,23,29 or CUSUM tests 27 . Interim analyses, with p value corrections for multiple looks , are a group sequential method.…”

Section: Present Resultsmentioning

confidence: 99%

“…The last trial 27 applied the CUSUM methodology in a nongraphical form. The authors made no mention of randomisation.…”

Section: Present Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Sequential analysis applied to clinical trials in dentistry: a systematic review

Bogowicz¹,

Flores-Mir²,

Major³

et al. 2008

Evid Based Dent

View full text Add to dashboard Cite

Clinical trials employ sequential analysis for the ethical and economic benefits it brings. In dentistry, as in other fields, resources are scarce and efforts are made to ensure that patients are treated ethically. The objective of this systematic review was to characterise the use of sequential analysis for clinical trials in dentistry. We searched various databases from 1900 through to January 2008. Articles were selected for review if they were clinical trials in the field of dentistry that had applied some form of sequential analysis. Selection was carried out independently by two of the authors. We included 18 trials from various specialties, which involved many different interventions. We conclude that sequential analysis seems to be underused in this field but that there are sufficient methodological resources in place for future applications.www.nature.com/ebd

show abstract

Clinical usability of aspartate aminotransferase to evaluate the prognosis of periodontal regeneration therapies: prospective, longitudinal study

et al. 2017

View full text Add to dashboard Cite

To evaluate the degree of periodontal tissue destruction, aspartate aminotransferase (AST) levels in the gingival crevicular fluid (GCF) are utilized as a predictor of periodontal therapy. We have previously shown that the usefulness of AST activities [periodontal tissue monitor (PTM) values] using a PTM-kit to evaluate the effects of initial periodontal therapy and periodontal regeneration therapy by enamel matrix derivative (EMD). This prospective, longitudinal study was conducted using 38 healthy and 80 periodontitis sites with probing depth (PD) of 5-10 mm for guided tissue regeneration (GTR) and EMD from 36 patients. GCF samples were used to evaluate PTM values at base line (BL) and after 6 months of surgeries (re-evaluation: RE), and periodontal examinations were performed concurrently. PTM values at BL were statistically improved at RE, accompanied by the improvement of periodontal parameters in both groups. PTM values and PD, and the clinical attachment level (CAL) showed high correlations. PD, CAL and bleeding on probing (BOP) were highly correlated with PTM values in both groups, whereas only PD showed a significant correlation with PTM values at RE in the GTR group. Change in the amounts of PD, CAL and BOP between BL and RE in both groups showed no correlation with PTM values. In the negative PTM value sites at BL in EMD group, the mean PD was significantly reduced at RE compared with positive PTM sites at BL. PTM values are able to be utilized as the biochemical predictor of prognosis after periodontal regeneration therapy.

show abstract

Relationship Between Crevicular Aspartate Aminotransferase Levels and Periodontal Disease Progression

Cited by 28 publications

References 23 publications

Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Sequential analysis applied to clinical trials in dentistry: a systematic review

Clinical usability of aspartate aminotransferase to evaluate the prognosis of periodontal regeneration therapies: prospective, longitudinal study

Contact Info

Product

Resources

About