Relationship between cytokine storm and SARS-CoV-2 infection's worsening

Guermouche, Baya; Dali-Sahi, Majda; Dennouni-Medjati, Nouria; Kachekouche, Youssouf; Merzouk, Hafida

doi:10.24875/aidsrev.21000070

“…In clinically severe cases of COVID-19, an excessive immune response due to an overreaction of the immune system or because the immune system is too weak to control the replication of the virus, causes an in ammatory storm process, also called cytokine storm 42 , which aggravates the lung damage and causes death. It has been reported that VitD can delay the progression of pulmonary brosis 43 , and can be used as an adjuvant therapy for patients with pulmonary brosis 44 , although the underlying mechanisms are not clear.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin D

Liu

¹

,

Song

²

,

Cai

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with insufficient VitD including patients with osteoporosis are more susceptible to SARS-COV-2 infection and patients with COVID-19 worsened or developed osteoporosis. It is currently unknown, however, whether osteoporosis and COVID-19 are linked by VitD insufficiency. In this study, 42 common targets for VitD on both COVID-19 and osteoporosis were identified among a total of 243 VitD targets. Further bioinformatic analysis revealed 8 core targets (EGFR, AR, ESR1, MAPK8, MDM2, EZH2, ERBB2 and MAPT) in the VitD-COVID-19-osteoporosis network. These targets are involved in the ErbB and MAPK signaling pathways critical for lung fibrosis, bone structural integrity, and cytokines through a crosstalk between COVID-19 and osteoporosis via the VitD-mediated conventional immune and osteoimmune mechanisms. Molecular docking confirmed that VitD binds tightly to the predicted targets. These findings support that VitD may target common signaling pathways in the integrated network of lung fibrosis and bone structural integrity as well as the immune systems. Therefore, VitD may serve as a preventive and therapeutic agent for both COVID-19 and osteoporosis.

show abstract

“…In clinically severe cases of COVID-19, an excessive immune response due to an overreaction of the immune system or because the immune system is too weak to control the replication of the virus, causes an www.nature.com/scientificreports/ inflammatory storm process, also called cytokine storm 38 , which aggravates the lung damage and causes death. It has been reported that VitD can delay the progression of pulmonary fibrosis 39 , and can be used as an adjuvant therapy for patients with pulmonary fibrosis 40 , although the underlying mechanisms are not clear.…”

Section: Discussionmentioning

confidence: 99%

Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D

Liu

¹

,

Song

²

,

Cai

³

et al. 2022

Sci Rep

4

0

View full text Add to dashboard Cite

Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with insufficient VitD including patients with osteoporosis are more susceptible to SARS-COV-2 infection and patients with COVID-19 worsened or developed osteoporosis. It is currently unknown, however, whether osteoporosis and COVID-19 are linked by VitD insufficiency. In this study, 42 common targets for VitD on both COVID-19 and osteoporosis were identified among a total of 243 VitD targets. Further bioinformatic analysis revealed 8 core targets (EGFR, AR, ESR1, MAPK8, MDM2, EZH2, ERBB2 and MAPT) in the VitD-COVID-19-osteoporosis network. These targets are involved in the ErbB and MAPK signaling pathways critical for lung fibrosis, bone structural integrity, and cytokines through a crosstalk between COVID-19 and osteoporosis via the VitD-mediated conventional immune and osteoimmune mechanisms. Molecular docking confirmed that VitD binds tightly to the predicted targets. These findings support that VitD may target common signaling pathways in the integrated network of lung fibrosis and bone structural integrity as well as the immune systems. Therefore, VitD may serve as a preventive and therapeutic agent for both COVID-19 and osteoporosis.

show abstract

Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome

Gunturk,

Seydel,

Yazici

et al. 2024

Turkish Journal of Biochemistry

0

View full text Add to dashboard Cite

Objectives The aim of this study was to evaluate the potential roles of plasma gelsolin (pGSN), transforming growth factor-beta1 (TGF-β1), and lysophosphatidic acid (LPA) as profibrotic and immune modulatory markers in patients with acute respiratory distress syndrome (ARDS) and patients with mild to moderate disease. Methods The study included 60 COVID-19 RT-PCR (+) patients who were divided into two groups as those who developed ARDS and those who did not and 18 non-COVID-19 volunteers. The pGSN, LPA and TGF-β1 levels were measured in the obtained plasma samples and evaluated together with routine laboratory parameters. Prognostic factors were assessed by multivariate analysis, and the predictive values of pGSN, TGF-β1 and LPA for developing ARDS were compared. Results While increased pGSN levels in COVID-19 patients were found to be decreased with the onset of ARDS; TGF-β1 and LPA levels were lower in patients than in control group, and the lowest levels were observed in patients who developed ARDS. In multivariate analyses, CRP and pGSN were identified as independent risk factors for developing ARDS. The cut-off value of the pGSN was 4,573 ng/mL (90 % sensitivity, 99 % specificity), (area under the curve: 0.977). The predictive values of pGSN is higher than TGF-β1 and LPA. Conclusions It can be said that the low concentrations of pGSN, TGF-β1 and LPA contribute to the development of ARDS due to the associated immunosuppressive role in COVID-19 patients.

show abstract

Relationship between cytokine storm and SARS-CoV-2 infection's worsening

Cited by 3 publications

References 0 publications

COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin D

COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin D

Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D

Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome

Contact Info

Product

Resources

About