2013
DOI: 10.5543/tkda.2013.02058
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Relationship between D-dimer and systemic embolism in patients with infective endocarditis

Abstract: Plasma DD levels are increased in patients with IE who suffered from clinically significant systemic embolism. Further studies are needed to determine the predictive value of DD levels for clinically silent systemic embolism.

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Cited by 8 publications
(5 citation statements)
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“…Among coagulation parameters, D-dimers have received the most interest, and their use in clinical practice is well established. Our results corroborate previous data suggesting a predictive value of D-dimers for the short-term prognosis of IE and the prediction of embolism [16,17,23,24] and septic embolic stroke [18]. Consistently, Meini et al recently found that very high levels of D-dimers signaled a worse in-hospital outcome in patients with acute, severe infections [13].…”
Section: Discussionsupporting
confidence: 92%
“…Among coagulation parameters, D-dimers have received the most interest, and their use in clinical practice is well established. Our results corroborate previous data suggesting a predictive value of D-dimers for the short-term prognosis of IE and the prediction of embolism [16,17,23,24] and septic embolic stroke [18]. Consistently, Meini et al recently found that very high levels of D-dimers signaled a worse in-hospital outcome in patients with acute, severe infections [13].…”
Section: Discussionsupporting
confidence: 92%
“…In a study (n=42) conducted by Bakal et al (7), the DD level of 425ng/dl or higher was seen to predict embolic incidents with a 77.0% sensitivity and 62.0% specificity. In this study, only left heart endocarditis was included, and systemic embolic events were investigated.…”
Section: Discussionmentioning
confidence: 92%
“…There are only a few studies exploring the relationship between the DD level and in-hospital mortality and embolism in patients with IE (7, 19). Turak et al (19), similar to our study, found that there was an association between a high DD level and in-hospital mortality in patients with IE.…”
Section: Discussionmentioning
confidence: 99%
“…To date, however, only four studies have been performed to evaluate the role of D-dimer in outcome prediction in IE. In a study including 42 patients, Bakal et al showed that plasma D-dimer levels were increased in patients with IE who suffered from clinically significant systemic embolism; D-dimer level > 425 ng/dL could predict clinical embolism with a sensitivity of 77% and specificity of 62% [ 28 ]. However, the association of D-dimer level with in-hospital mortality in patients with IE was not studied.…”
Section: Discussionmentioning
confidence: 99%