Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and <i>β</i>-Cell Dysfunction

Liu, Yiwen; Ma, Chifa; Lv, Le; Li, Pingping; Ma, Chunxiao; He, Song; Zeng, Jing; Ping, Fan; Zhang, Huabing; Li, Wei; Xu, Lingling; Li, Yuxiu

doi:10.1155/2020/5384909

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…SOD-Cu/Zn did not show a significant difference, and this suggests a possible damage to the mitochondria in the kidney cells. This antioxidant enzyme (SOD-Mn) is located in the mitochondrial matrix and participates in the dismutation of the O 2 − to H 2 O 2 [ 46 ]. A decrease in the SOD activity is associated with MS regardless of cellular aging, OS markers and dietary risk factors.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

et al. 2021

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Metabolic syndrome (MS) is the association of three or more pathologies among which obesity, hypertension, insulin resistance, dyslipidemia, and diabetes are included. It causes oxidative stress (OS) and renal dysfunction. Hibiscus sabdariffa L. (HSL) is a source of natural antioxidants that may control the renal damage caused by the MS. The objective of this work was to evaluate the effect of a 2% HSL infusion on renal function in a MS rat model induced by the administration of 30% sucrose in drinking water. 24 male Wistar rats were divided into 3 groups: Control rats, MS rats and MS + HSL rats. MS rats had increased body weight, systolic blood pressure, triglycerides, insulin, HOMA index, and leptin (p ≤ 0.04). Renal function was impaired by an increase in perfusion pressure in the isolated and perfused kidney, albuminuria (p ≤ 0.03), and by a decrease in clearance of creatinine (p ≤ 0.04). The activity of some antioxidant enzymes including the superoxide dismutase isoforms, peroxidases, glutathione peroxidase, glutathione-S-transferase was decreased (p ≤ 0.05). Lipoperoxidation and carbonylation were increased (p ≤ 0.001). The nitrates/nitrites ratio, total antioxidant capacity, glutathione levels and vitamin C were decreased (p ≤ 0.03). The treatment with 2% HSL reversed these alterations. The results suggest that the treatment with 2% HSL infusion protects renal function through its natural antioxidants which favor an improved renal vascular response. The infusion contributes to the increase in the glomerular filtration rate, by promoting an increase in the enzymatic and non-enzymatic antioxidant systems leading to a decrease in OS and reestablishing the normal renal function.

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Section: Discussionmentioning

confidence: 99%

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

et al. 2021

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“…The decrease in SOD activity can be attributable to a rise in endogenous ROS generation, as indicated by an increase in MDA and ROS byproducts. Furthermore, Liu study demonstrated that there is an independent association between decreased SOD activity and MS as well as possible mediating effect of impaired insulin sensitivity and β-cell dysfunction on the relationship between decreased SOD activity and MS (Liu et al, 2020).…”

Section: Antioxidant Statusmentioning

confidence: 88%

Hormone Disorders And Its Correlation with Lipid Profile And Oxidative Stress Biomarkers in Metabolic Syndrome Patients

M. Khaleel,

A. Mosa

2023

UOD

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Background and aims: Metabolic syndrome" (MS) refers to a group of interrelated metabolic risk factors of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The aim of this work is investigation the correlation of melatonin and sprosin hormones with lipid profile and oxidant/antioxidant status in sera of MS patients and to assess the potential of these parameters as diagnostic biomarkers for metabolic syndrome using receiver-operating characteristic (ROC) curve analysis Methods: This case-control study involved 82 MS patients and 60 controls. The study examined serum levels of glucose, melatonin, asprosin, lipid profile, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione-S-transferase (GST), reduced glutathione (GSH), and total antioxidant activity (AOA). Results:The patients group had significantly lower serum levels of melatonin hormone, SOD, GST, GSH, and AOA. While, glucose and asprosin levels increased in MS patients compared to the controls. Similarly, the lipid profile, including cholesterol, very low density lipoprotein (VLDL), and triglyceride (TG), and low density lipoprotein (LDL), were significantly increased. Furthermore, correlation analysis revealed that levels of melatonin were negatively associated with cholesterol and positively associated with TG. Asprosin has negative significant correlation with GSH. Regarding ROC curve analysis, glucose, asprosine, VLDL, TG, and MDA were demonstrated as diagnostic biomarkers for metabolic syndrome. Conclusions: The study found that melatonin hormone was negatively associated with cholesterol and positively associated with TG, while Asprosin has negative significant correlation with GSH. Additionally, this study proved also that glucose, asprosin, VLDL, TG, and MDA can be used as metabolic syndrome's predictive biomarkers.

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“…In addition, Suriyaprom et al found significantly lower SOD activity and vitamin C concentration and higher white blood cell counts in Thais with metabolic syndrome [66]. What is more, Liu et al indicated that SOD activity can be an independent predictor of metabolic syn-drome, as the decrease in SOD activity was found to be independent of cell aging and pro-oxidants, as well as calorie intake and dietary antioxidants [67].…”

Section: Oxidative Stress and Inflammation Markers In Elderly Individ...mentioning

confidence: 99%

Inflammation and Oxidative Stress in Frailty and Metabolic Syndromes—Two Sides of the Same Coin

Dzięgielewska-Gęsiak

Muc-Wierzgoń

2023

Metabolites

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In developed countries, aging is often seen as typical, but it is made complicated by many disorders and co-morbidities. Insulin resistance seems to be an underlying pathomechanism in frailty and metabolic syndromes. The decline in insulin sensitivity leads to changes in the oxidant–antioxidant balance and an accelerated inflammatory response, especially by adipocytes and macrophages in adipose tissue, as well as muscle mass density. Thus, in the pathophysiology of syndemic disorders—the metabolic syndrome and frailty syndrome—an extremely important role may be played by increased oxidative stress and pro-inflammatory state. Papers included in this review explored available full texts and the reference lists of relevant studies from the last 20 years, before the end of 2022; we also investigated the PubMed and Google Scholar electronic databases. The online resources describing an elderly population (≥65 years old) published as full texts were searched for the following terms: “oxidative stress and/or inflammation”, “frailty and/or metabolic syndrome”. Then, all resources were analyzed and narratively described in the context of oxidative stress and/or inflammation markers which underlie pathomechanisms of frailty and/or metabolic syndromes in elderly patients. So far, different metabolic pathways discussed in this review show that a similar pathogenesis underlies the development of the metabolic as well as frailty syndromes in the context of increased oxidative stress and acceleration of inflammation. Thus, we argue that the syndemia of the syndromes represents two sides of the same coin.

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Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

Cited by 10 publications

References 43 publications

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

Hormone Disorders And Its Correlation with Lipid Profile And Oxidative Stress Biomarkers in Metabolic Syndrome Patients

Inflammation and Oxidative Stress in Frailty and Metabolic Syndromes—Two Sides of the Same Coin

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