Relationship between depression and borderline personality disorder

Koenigsberg, Harold W.; Anwunah, Iseoma; New, Antonia S.; Mitropoulou, Vivian; Schopick, Frances; Siever, Larry J.

doi:10.1002/(sici)1520-6394(1999)10:4<158::aid-da4>3.0.co;2-b

Cited by 69 publications

(39 citation statements)

References 74 publications

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“…Major depression typically involves a more fixed depressed mood, whereas depression in BPD tends to be characterized by more mood reactivity. One hypothesis is that low serotonergic activity and high cholinergic sensitivity may be common to both BPD and depression, but different abnormalities in noradrenergic function, which modulates the extent of engagement with the social environment, may result in the differences in reactivity of mood (Koenigsberg et al, 1999). Though this work is preliminary and far from definitive, it illustrates the more general point, which is that two disorders (BPD and depression, in this case) may share some etiologic mechanisms and differ on others.…”

Section: Table 1 Improvement In Axis I Disorders As Predictors Of Remmentioning

confidence: 99%

Associations in the Course of Personality Disorders and Axis I Disorders Over Time.

Shea¹,

Stout²,

Yen³

et al. 2004

Journal of Abnormal Psychology

178

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Whereas personality disorders and Axis I disorders have repeatedly been found to have high rates of co-occurrence (Dolan-Sewell, Krueger, & Shea, 2001), findings regarding specific associations between pairs of personality disorders and Axis I disorders have been less consistent. The lack of consistency may be due largely to methodological factors, particularly the frequent use of cross-sectional studies and the variability across studies in sampling methods, base rates of disorders studied, and assessment instruments.

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Section: Table 1 Improvement In Axis I Disorders As Predictors Of Remmentioning

confidence: 99%

Associations in the Course of Personality Disorders and Axis I Disorders Over Time.

Shea¹,

Stout²,

Yen³

et al. 2004

Journal of Abnormal Psychology

178

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“…7 Several studies have shown that BPD probands have a higher prevalence of affective disorders in their relatives compared to other personality disorders. 8–10 In addition, a multivariate twin study and significant longitudinal associations between BPD and depressive symptoms suggest that the relationship is due to a common latent factor. 11–13 Due to these shared characteristics, some researchers have proposed that chronic depression might be better conceptualized as a personality disorder and others believe that borderline personality is a variant of a mood disorder.…”

mentioning

confidence: 99%

The Relationship Between Borderline Personality Disorder and Major Depression in Later Life: Acute Versus Temperamental Symptoms

Galione

Oltmanns

2013

The American Journal of Geriatric Psychiatry

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Objective A recent issue in the personality disorder field is the prevalence and course of Axis II symptoms in later life. Focusing on the presentation of personality disorder criteria over time may have some utility in exploring the relationship between borderline personality disorder (BPD) and major depression in older adults. Temperamental personality symptoms are relatively resistant to change but tend to be nonspecific to disorders, while acute symptoms remit relatively quickly. We predicted that temperamental BPD symptoms would be positively correlated with a history of depression and did not expect to find a relationship between major depression and acute BPD symptoms. Method One thousand six hundred and thirty participants between the ages of 55 and 64 were recruited to participate in a community-based longitudinal study representative of the St. Louis area. Participants completed a battery of assessments at baseline, including diagnostic interviews for all ten personality disorders and major depressive disorder. Results Temperamental and acute BPD symptoms were significantly correlated with a history of major depression. After adjustments were made for the effects of temperamental symptoms on depression, acute symptoms were no longer correlated with a history of depression. As predicted, temperamental symptoms remained significantly related to depression, even after controlling for the effects of acute symptoms. BPD acute symptoms showed a unique negative correlation with the amount of time following remission from a depressive episode. Conclusions Overall, this study supports associations between major depression and borderline personality in older adults. The findings indicate that a history of major depression is primarily related to stable BPD symptoms related to emotional distress, which are more prevalent in older adults compared to acute features.

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“…Possible interference of any of these disorders with SERT binding was excluded in our subjects. Depressive symptoms as a common clinical feature in BPD 23 were present in our group of patients, but unlike other studies, 35,36 the respective scores were not associated with SERT availability.…”

Section: Discussionmentioning

confidence: 99%

“…We assessed depressive symptoms as a common feature cooccurring in people with BPD, 23 using the Beck Depression Inventory (BDI), a widely used 21-item self-report rating inventory measuring attitudes and symptoms characteristic of depression. 24 …”

Section: Clinical Assessmentsmentioning

confidence: 99%

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

Schaaff¹,

Koch²,

Pöpperl³

et al. 2007

Pharmacopsychiatry

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Objective: Serotonergic dysfunction is considered to be involved in the pathophysiology of borderline personality disorder (BPD). The aim of this study was to investigate serotonin transporter availability in patients with BPD as a marker of the central serotonergic system. Methods: Eight unmedicated patients with BPD and 9 healthy control subjects received single photon emission computed tomography (SPECT) 4 hours after injection of 185 MBq [I-123] . As a measure of brain serotonin transporter (SERT) availability, ratios of specific-to-nonspecific [I-123] ADAM binding for the brainstem and hypothalamus were calculated with an occipital reference. Levels of impulsiveness and depressive symptoms were assessed with the Barratt Impulsiveness Scale and the Beck Depression Inventory. Results: Mean specific-to-nonspecific ratios showed a 43% higher brainstem and a 12% higher hypothalamus ADAM binding in patients, compared with control subjects. We found significant correlations of ADAM binding with both age and impulsiveness but not depression. Associations of BIS scores with ADAM binding remained significant after controlling for age and depression (r = 0.69, p < 0.01). Conclusion: The study provides evidence of a serotonergic dysfunction in patients with BPD and suggests a serotonergic component in the pathophysiology of the disorder. SERT binding reflected the level of impulsiveness as a common feature in BPD.Objectif : On considère que le dysfonctionnement sérotoninergique joue un rôle dans la pathophysiologie du trouble de personnalité limite (TPL). Cette étude visait à étudier, chez les patients atteints d'un TPL, la disponibilité du transporteur de la sérotonine comme marqueur du système sérotoninergique central. Méthodes : Huit patients atteints d'un TPL qui ne prenaient pas de médicament et neuf sujets témoins en bonne santé ont été soumis à une tomographie d'émission monophotonique (TEM) 4 heures après avoir reçu par injection 185 MBq [I-123] ). Pour mesurer la disponibilité du transporteur de la séroto-nine dans le cerveau (SERT), on a calculé des ratios de fixation spécifique:non spécifique [I-123] d'ADAM dans le tronc cérébral et l'hypothalamus en utilisant un point de référence occipital. On a évalué les niveaux d'impulsivité et de symptômes dépressifs au moyen de l'échelle d'impulsivité de Barratt (EIB) et du questionnaire de dépression de Beck. Résultats : Les ratios de fixation spécifique:non spé-cifique moyens ont montré que la fixation de l'ADAM était plus élevée de 43 % dans le tronc cérébral et de 12 % dans l'hypothalamus chez les patients comparativement aux sujets témoins. Nous avons constaté des liens importants entre la fixation de l'ADAM et à la fois l'âge et l'impulsivité, mais non la dépression. Les liens entre les résultats de l'EIB et la fixation de l'ADAM sont demeurés importants compte tenu de l'âge et de la dépression (r = 0,69, p < 0,01). Conclusion : L'étude présente des preuves de dysfonctionnement séro-toninergique chez les patients atteints de TPL et indique la présence d'un élé...

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Relationship between depression and borderline personality disorder

Cited by 69 publications

References 74 publications

Associations in the Course of Personality Disorders and Axis I Disorders Over Time.

Associations in the Course of Personality Disorders and Axis I Disorders Over Time.

The Relationship Between Borderline Personality Disorder and Major Depression in Later Life: Acute Versus Temperamental Symptoms

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

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