Relationship between dietary carbohydrates intake and circulating sex hormone‐binding globulin levels in postmenopausal women

Huang, Mengna; Liu, Jinjie; Lin, Xiaochen; Goto, Atsushi; Song, Yiqing; Tinker, Lesley F.; Chan, Kei Hang Katie; Liu, Simin

doi:10.1111/1753-0407.12550

Cited by 15 publications

(11 citation statements)

References 43 publications

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“…Diet and nutritional status contribute to the etiology of the disease by influencing blood estrogen levels [ 19 ]. Huang et al showed that dietary factors can influence serum sex-hormone activity and concentrations [ 20 ]. Certain dietary fats have the potential to alter endogenous hormone metabolism, and fatty acid intake has been associated with increased levels of endogenous estrogen [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Low Diet Quality and Nutritional Knowledge in Women with Endometriosis: A Pilot Study

Bogusz,

Górnicka

2024

Healthcare

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Endometriosis is a chronic gynecological disease characterized by ectopic endometrial tissue outside the uterus that can cause chronic pain, dysmenorrhea, fatigue, and infertility. The aim of this study was to assess diet quality and nutritional knowledge of women with endometriosis. A questionnaire was used to collect data on lifestyle, dietary habits and nutritional knowledge from 90 women. More than 80% of women with endometriosis (82.2%) confirmed that diet and lifestyle are related to the progression of endometriosis. After being diagnosed with endometriosis, 77.3% of respondents reported a change in their dietary habits and made various changes to their diet by increasing or eliminating the consumption of certain foods. The majority declared reducing pro-inflammatory products, increasing anti-inflammatory foods, including the consumption of vegetables and fruits, avoiding white/or red/or processed meat, and avoiding sweets. Nevertheless, diet quality as assessed by the pro-healthy diet index (pHDI-10) and the Mediterranean Diet Score (MDS) showed a low intensity of consumption of pro-healthy food (average pHDI-10 value 31.4%; MDS 7.55/14 points, p = 0.0001). Women with endometriosis reported lower than recommended consumption of fruits, vegetables, dairy products and whole grains. A higher percentage of healthy controls had a “good” level of nutritional knowledge than women with endometriosis. The results of our study highlight the need to improve diet quality and nutritional knowledge among women with endometriosis as well as developing targeted dietary recommendations to help improve well-being and reduce the pain symptoms of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Low Diet Quality and Nutritional Knowledge in Women with Endometriosis: A Pilot Study

Bogusz,

Górnicka

2024

Healthcare

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“…Experimental studies have shown that a high-fiber diet has a down-regulation role on inflammation and reduces CRP level (24). A diet rich in fiber could elevate SHBG levels (25) and thus decrease the level of bioavailable estrogens. On the contrary, in the study of Savaris, high dietary fiber-intake was associated with an increased risk of endometriosis (26).…”

Section: Discussionmentioning

confidence: 99%

The association of food consumption and nutrient intake‎ with endometriosis risk in Iranian women: A case-control study

Youseflu

Sadatmahalleh

Mottaghi

et al. 2019

IJRM

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Background: Endometriosis, defined as the attendance of endometrial-like lesions in extra uterine locations, causes pain, infertility, and reduced quality of life. Objective: To evaluate the relationship between food consumption and nutrient intake with risk of endometriosis. Materials and Methods: Of the 156 women approached for the study, 78 women had endometriosis and 78 healthy women were included in the control group. Dietary data were collected using a validated 147-item semi-quantitative Food Frequency Questionnaire (FFQ) with the standard serving size. A logistic regression model was used to determine the association of macronutrients and energy intake with the risk of endometriosis. Results: In women with higher intake of protein, especially animal protein, monounsaturated fatty acids, soluble and insoluble fiber, oleic acid, eicosapentaenoic acid, and docosahexaenoic acid endometriosis is less common (p < 0.05). High consumption of vegetables, fruits, red meat, yellow vegetables, potatoes, legumes, dairy products, liquid oil, and low intake of fried potatoes was associated with a lower risk of endometriosis (p < 0.05). Conclusion: Regarding the association of dietary intake on endometriosis risk, counseling about improving the dietary structure can contribute toward the prevention and control of endometriosis. Key words: Endometriosis, Macronutrient, Diet, Case-control study.

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“…11 On the contrary, low-carbohydrate diets, insulin sensitizers, and phytoestrogens can increase SHBG production by reducing liver fat production and ameliorating fatty liver so as to prevent the progression of ovarian pathology and restore reproductive function. [51][52][53] SHBG Levels and Lipid Metabolism Disorders in Women with PCOS PCOS with lipid metabolism disorders has been attracting increasing attention. PCOS patient dyslipidemia is mainly characterized by elevated levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL).…”

Section: Shbg Levels and Ovarian Dysfunction In Women With Pcosmentioning

confidence: 99%

Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome: Mechanisms, Manifestations, Genetics, and Treatment

Xing¹,

Zhang²,

Zhao³

et al. 2022

IJWH

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases causing infertility in women of childbearing age. It is characterized by hyperandrogenemia (HA), chronic anovulation, and polycystic ovary morphology (PCOM). Most women with PCOS have metabolic abnormalities. Sex hormone-binding globulin (SHBG), a transport carrier that binds estrogen and androgens and regulates their biological activity, is usually used as an indicator of hyperandrogenism in women with PCOS. Low serum SHBG levels are considered a biomarker of metabolic abnormalities and are associated with insulin resistance (IR), HA, and abnormal glucose and lipid metabolism in PCOS patients. SHBG is also related to the long-term prognosis of PCOS, whereas SHBG gene polymorphism is associated with PCOS risk. In addition, the administration of metformin (MET), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), thiazolidinediones (TZDs), compound oral contraceptives (COCs), as well as nutrient supplements such as inositol (MI), vitamin D, and synbiotics can regulate SHBG levels to ameliorate PCOS complications and improve prognosis. This review focuses on the interaction between SHBG and various PCOS complications as well as the regulation of SHBG by various drugs and nutrients and its therapeutic effects on PCOS.

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Relationship between dietary carbohydrates intake and circulating sex hormone‐binding globulin levels in postmenopausal women

Abstract: The findings suggest that low GL or GI diets with low sugar and high fiber content may be associated with higher serum SHBG concentrations among postmenopausal women. Future studies investigating whether lower GL or GI diets increase SHBG concentrations are warranted.

Cited by 15 publications

References 43 publications

Low Diet Quality and Nutritional Knowledge in Women with Endometriosis: A Pilot Study

Low Diet Quality and Nutritional Knowledge in Women with Endometriosis: A Pilot Study

The association of food consumption and nutrient intake‎ with endometriosis risk in Iranian women: A case-control study

Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome: Mechanisms, Manifestations, Genetics, and Treatment

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