Relationship between disc margin to fovea distance and central visual field defect in normal tension glaucoma

Lee, Marvin; Jin, Hosung; Ahn, Jae In

doi:10.1007/s00417-013-2513-2

Cited by 9 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing the results obtained in Knaapi´s study and the findings of our investigation, one has to take into account the marked difference between both studies in the age and in the background of the study participants. Lee and colleagues measured the distance between the temporal optic disc margin to the fovea distance in 88 patients with normal-tension glaucoma [ 8 ]. They found that in patients with a sparing of the central field the disc margin-fovea distance (3.88 ± 0.28 mm) was longer ( P = 0.002) than in the group with glaucomatous central visual field loss (3.64 ± 0.40 mm) [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

et al. 2015

View full text Add to dashboard Cite

PurposeTo measure the distance between the optic disc center and the fovea (DFD) and to assess its associations.MethodsThe population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals aged 50+ years. The DFD was measured on fundus photographs.ResultsReadable fundus photographs were available for 2836 (81.8%) individuals. Mean DFD was 4.76 ± 0.34mm (median: 4.74 mm; range: 3.76–6.53mm). In multivariate analysis, longer DFD was associated with longer axial length (P<0.001; standardized correlation coefficient beta: 0.62), higher prevalence of axially high myopia (P<0.001; beta:0.06), shallower anterior chamber depth (P<0.001; beta:-0.18), thinner lens thickness (P = 0.004; beta: -0.06), smaller optic disc-fovea angle (P = 0.02; beta: -0.04), larger parapapillary alpha zone (P = 0.008; beta: 0.05), larger parapapillary beta/gamma zone (P<0.001; beta: 0.11), larger optic disc area (P<0.001; beta: 0.08), lower degree of cortical cataract (P = 0.002; beta: -0.08), and lower prevalence of age-related macular degeneration (P = 0.001; beta: -0.06). Bruch´s membrane opening-fovea distance (DFD minus disc radius minus parapapillary beta/gamma zone width) in non-glaucomatous eyes was not significantly (P = 0.60) related with axial length in emmetropic or axially myopic eyes (axial length ≥23.5 mm), while it increased significantly (P<0.001; r: 0.32) with longer axial length in eyes with an axial length of <23.5mm. Ratio of mean DFD to disc diameter was 2.65 ± 0.30. If the ratio of disc-fovea distance to disc diameter was considered constant and if the individual disc diameter was calculated as the individual disc-fovea distance divided by the constant factor of 2.65, the resulting calculated disc diameter differed from the directly measured disc diameter by 0.16 ±0.13 mm (median: 0.13 mm, range: 0.00–0.89 mm) or 8.9 ± 7.3% (median: 7.4%; range: 0.00–70%) of the measured disc diameter.ConclusionsDFD (mean: 4.76mm) increases with longer axial length, larger parapapillary alpha zone and parapapillary beta/gamma zone, and larger disc area. The axial elongation associated increase in DFD was due to an enlargement of parapapillary beta/gamma zone while the Bruch’s membrane opening-fovea distance did not enlarge with longer axial length. This finding may be of interest for the process of emmetropization and myopization. Due to its variability, the disc-fovea distance has only limited clinical value as a relative size unit for structures at the posterior pole.

show abstract

Section: Discussionmentioning

confidence: 99%

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In contrast to our study, Knaapi and associates did not find significant associations between the disc-fovea distance and refractive error (or axial length), although one child with axially high myopia had an above-average disc-fovea distance of 6.35 mm. Lee and colleagues measured the distance between the temporal optic disc margin to the fovea distance in 88 patients with normal-tension glaucoma [ 40 ]. They found that in patients with a sparing of the central field the disc margin-fovea distance (3.88 ± 0.28 mm) was longer (P = 0.002) than in the group with glaucomatous central visual field loss (3.64 ± 0.40 mm).…”

Section: Discussionmentioning

confidence: 99%

Macular Bruch´s Membrane Length and Axial Length. The Beijing Eye Study

et al. 2015

View full text Add to dashboard Cite

PurposeTo assess whether macular Bruch´s membrane gets lengthened in axial myopia.MethodsUsing the enhanced depth imaging mode of spectral-domain optical coherence tomography and examining a subgroup of participants of the population-based cross-sectional Beijing Eye Study, we measured the length of Bruch´s membrane (“MacBMLength”) from the fovea to the temporal edge of parapapillary gamma zone, and the distance between the fovea and the temporal optic disc border. Parapapillary gamma zone was defined as the parapapillary region without Bruch´s membrane. We additionally measured ocular biometric parameters and assessed non-ophthalmologic variables.ResultsMeasurements of MacBMLength were performed on 322 individuals. MacBMLength (mean: 3.99±0.33 mm; range: 3.17–4.93 mm) was not significantly associated with any systemic parameter or ocular biometric parameter. Gamma zone width (mean: 0.18±0.30mm; range: 0.00–2.61mm) was associated (multivariate analysis; correlation coefficient r:0.80) with longer axial length (P<0.001; standardized correlation coefficient beta: 0.60; non-standardized correlation coefficient B:0.11; 95%CI: 0.09,0.14) and with longer fovea-optic disc border distance (P<0.001; beta:0.28; B:0.19; 95%CI:0.14,0.25), but not with MacBMLength (P = 0.42). Fovea-temporal disc border distance (mean: 4.16±0.44mm; range: 3.17–5.86mm) was associated (overall correlation coefficient: 0.68) with longer axial length (P<0.001; beta: 0.36; B: 0.10; 95%CI: 0.06, 0.13), after adjusting for flatter anterior chamber depth (P = 0.003; beta:-0.14; B:-0.14; 95%CI: -0.23,-0.05) and wider parapapillary gamma zone (P<0.001; beta:0.42; B:0.62; 95%CI:0.44,0.81).ConclusionsIn contrast to parapapillary gamma zone width and fovea-disc border distance, MacBMLength was not significantly associated with axial length. Axial elongation associated increase in fovea-disc distance may predominantly occur through development or elongation of parapapillary gamma zone, while macular Bruch´s membrane may mostly be independent of axial elongation.

show abstract

“…They characterize the position of the optic nerve head in relationship to the fovea (Mok & Lee 2002;Rohrschneider 2004;Jehtani et al 2010;Jonas et al 2011a;van de Put et al 2013;Shin et al 2013;Choi et al 2014;Lee et al 2014). They characterize the position of the optic nerve head in relationship to the fovea (Mok & Lee 2002;Rohrschneider 2004;Jehtani et al 2010;Jonas et al 2011a;van de Put et al 2013;Shin et al 2013;Choi et al 2014;Lee et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The optic disc-fovea distance (DFD) and optic disc-fovea angle (DFA) are important landmarks of the posterior fundus. They characterize the position of the optic nerve head in relationship to the fovea (Mok & Lee 2002;Rohrschneider 2004;Jehtani et al 2010;Jonas et al 2011a;van de Put et al 2013;Shin et al 2013;Choi et al 2014;Lee et al 2014). The DFD can be of importance as an anatomical measure of the posterior fundus, and the DFA influences the position of the perimetric blind spot in spatial relationship to the visual centre.…”

Section: Introductionmentioning

confidence: 99%

Optic disc–fovea distance and myopia progression in school children: the Beijing Children Eye Study

Yin

Liu

Tang

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

In adolescent school children, axial elongation-associated increase in DFD was mainly due to an enlargement (+300%) of parapapillary gamma zone, while macular BM length increased to minor degree (+18%). Gamma zone enlargement was correlated with axial elongation-associated vertical optic disc rotation, potentially due to an increased backward pull of the optic nerve on the temporal optic disc border.

show abstract

Relationship between disc margin to fovea distance and central visual field defect in normal tension glaucoma

Abstract: Eyes with a shorter DFD should be monitored carefully because central VF involvement appears to be related to shorter DFD in NTG patients with mild VF defects.

Cited by 9 publications

References 25 publications

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

Optic Disc - Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011

Macular Bruch´s Membrane Length and Axial Length. The Beijing Eye Study

Optic disc–fovea distance and myopia progression in school children: the Beijing Children Eye Study

Contact Info

Product

Resources

About