Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients

Abstract

ObjectiveTo compare clinical and laboratory features of elderly patients with and without diverticulosis and assess factors related to hepatosteatosis.MethodThis retrospective case–control study analysed the clinical and laboratory data, colonoscopy and abdominal ultrasonography records of patients >65 years who underwent colonoscopies. Subjects were categorized according to the presence and absence of colonic diverticulosis. Univariate/multivariate logistic regression analyses were performed to evaluate the independent predictive factors of hepatosteatosis.ResultsA total of 355 patients were enrolled in the study: 169 had colonic diverticulosis; and 186 without colonic diverticulosis formed the control group. Age, sex and chronic disorders associated with the metabolic syndrome did not differ between the diverticulosis and control groups. The rate of hepatosteatosis was lower in patients with diverticulosis compared with the control group (27% versus 42%, respectively). Diabetes mellitus, hyperlipidaemia and hepatosteatosis were more common among patients aged <75 years. In the multivariate logistic regression analysis, diverticulosis remained an independent predictor of hepatosteatosis (odds ratio 0.529; 95% confidence interval 0.323, 0.866). Other independent predictive factors in the multivariate analysis were triglyceride and albumin.ConclusionDiverticulosis in the elderly was found to be a negative predictor of hepatosteatosis. Higher values of albumin and triglyceride in conjunction with the absence of diverticulosis may be suggestive of nonalcoholic fatty liver disease in the elderly.

Evolution of Viscosity and Structure Property of Vanadium Slag during Iron‐Extracting Reduction Process

“…To determine the composition of the experimental slag system at 1873 K, the pseudo‐hexahydric phase diagram of FeO−SiO 2 −Cr 2 O 3 −CaO (10 wt%)−TiO 2 (10 wt%)−MnO (12 wt%) at an oxygen partial pressure of 10 −8 was calculated using FACTSage 7.0 based on the compositions of the samples, using the normalized method, [ 28–30 ] and A1−A5 corresponded to S1–S5, as shown in Figure 4 . The solid–liquid ratio of the slag decreased from 21.5% to 1.9% when the FeO content decreased from 37 to 11 wt%, calculated using the Equilib Module in FACTSage 7.0, [ 31 ] consistent with the XRD and SEM results. Considering the extremely limited thermodynamic data available for V, the pseudo‐hexahydric phase diagram does not exhaustively reflect the experimental slag system; however, it provides a relatively accurate phase distribution for the complex slag system.…”

Recovery of Precious Metals (Au, Ag, Pt, and Pd) from Urban Mining Through Copper Smelting

“…[1,2] It has been reported that about 600 million tons of copper were produced during the past two hundred years, of which around 20 pct was produced by Outotec flash smelting technology. [3] However, because of continuous depletion of ore-based copper mineral resources, as well as tighter environmental regulations and stronger demands for actions towards circular economy, [4] secondary copper resources such as industrial copper scrap and waste electrical and electronic equipment (WEEE) are increasingly being regarded as important copper resources.…”

The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

“…This study reported that moderate and severe fatty liver disease, as well as waist-hip ratio, were risk factors for ADD, highlighting the possible role of central obesity and NAFLD in the pathogenesis of ADD [18]. Contrary to these findings, Sahin et al [21] found that in elderly patients, diverticulosis is a negative predictor of liver steatosis. According to this study, diverticulosis could be an indirect sign of malnutrition in patients over 75 years of age, since higher values of albumin and triglycerides, were identified as independent predictors of liver steatosis [21].…”

“…Contrary to these findings, Sahin et al [21] found that in elderly patients, diverticulosis is a negative predictor of liver steatosis. According to this study, diverticulosis could be an indirect sign of malnutrition in patients over 75 years of age, since higher values of albumin and triglycerides, were identified as independent predictors of liver steatosis [21]. The age difference between the patients included in these studies may be the reason for these conflicting findings.…”

“…Both NAFLD and CD are more severe in the elderly [8]. Additionally, the incidence of NAFLD has an 'inverted U-shape' distribution, with a decreasing rate of newly diagnosed cases after the 6 th decade in men and the 7 th decade in women [21,22]. Nevertheless, NASH and cirrhosis that result from chronic inflammation typically develop in advanced age [23].…”