Relationship between Dry Eye Parameters and Anterior Corneal Higher-Order Aberrations Measured by Two Different Instruments

Abstract

Purpose:To compare the corneal first surface higher-order aberrations (HOAs) of normal subjects and patients with dry eye using KR-1W ® (Topcon Corp., Tokyo, Japan) and Pentacam ® HR (Oculus Inc., Dutenhofen, Germany). We analyzed the relationship between the aberrations and the diagnostic parameters of dry eye. Methods:We evaluated anterior corneal HOAs in 71 normal eyes and 71 dry eyes using KR-1W ® and Pentacam ® . Dry eye patients were examined for fluorescein staining, tear break-up time (TBUT), and Schirmer I test. Ocular Surface Disease Index (OSDI) was used for assessment of subjective symptoms in dry eye patients. Results: HOAs measured by both instruments were greater in the dry eye group than in the control group, although HOAs using KR-1W ® only achieved statistical significance. The anterior corneal HOAs measured by the 2 instruments were significantly correlated with superficial punctate keratitis. Moreover, TBUT and the Shirmer I test negatively correlated, and OSDI positively correlated, with anterior corneal HOAs. Conclusions:The HOAs in patients with dry eye were significantly different from controls and tended to increase with disease severity. KR-1W ® might be more useful than Pentacam ® to detect tear film instabilities.J Korean Ophthalmol Soc 2015;56(1):6-12