Relationship between Early-Onset Neonatal Sepsis and Red Blood Cell Distribution Width (RDW)

Cosar, Hese; Yılmaz, Özgür; Temür, Muzaffer; P, Ozun Ozbay; Bulut, Yasemin; Karakulak, Murat

doi:10.4172/2329-8790.1000266

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…10 Low birth weight and prematurity are associated with immaturity of the cellular and humoral immune system, which are characterized by reduced lymphocyte proliferation and immunoglobulin production. 11 Of the seven laboratory parameters measured, only presepsin level differed significantly between non-survivors and survivors. Median presepsin level was significantly higher in infants who died within seven days of diagnosis than in those who survived.…”

Section: Discussionmentioning

confidence: 90%

Presepsin level as risk factor for mortality in premature infants with neonatal sepsis

Romli¹,

Yuniati²,

Hilmanto³

2021

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Background Prematurity is a risk factor of neonatal sepsis and its associated morbidities and mortality. Most deaths in neonatal sepsis occur within the first seven days. Presepsin has been reported as one of the earliest biomarkers for predicting mortality. Objective To determine the association between presepsin levels and mortality risk, as well as the optimal presepsin cut-off point for predicting mortality, in premature infants with neonatal sepsis .Method This was an observational prospective cohort study on 62 preterm infants born at 28 to <37 weeks’ gestation. We recorded clinical and laboratory characteristics, performed blood culture, and measured presepsin levels at initial diagnosis of sepsis. Subjects were followed for seven days and their outcome (death or survival) recorded. We evaluated the association between clinical and laboratory characteristics, including presepsin levels, with sepsis outcome. We also constructed a receiver-operator characteristics curve to determine the optimal cut-off point of presepsin as a predictor of sepsis mortality. Results Only blood culture results (P=0.006) and presepsin level (P<0.001) were significantly associated with sepsis outcome on the seventh day. The optimal presepsin cut-off value for predicting mortality was 1057 ng/mL, with an area under curve of 80.4%, sensitivity of 60.71%, and specificity of 88.24%. A presepsin level of >1057 ng/mL was associated with increased mortality [RR 3.02; 95%CI 68.3 to 89.4; P<0.001]. Conclusion In preterm infants with neonatal sepsis, an elevated presepsin level at diagnosis is a significant risk factor for mortality within seven days. Presepsin can be used as an early biomarker of sepsis outcome.

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Section: Discussionmentioning

confidence: 90%

Presepsin level as risk factor for mortality in premature infants with neonatal sepsis

Romli¹,

Yuniati²,

Hilmanto³

2021

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A study of red cell distribution width and neonatal sepsis at Soba University Hospital, Khartoum, Sudan

Omer¹,

Mohammed²

2021

Sudan J Paed

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Relationship between Early-Onset Neonatal Sepsis and Red Blood Cell Distribution Width (RDW)

Abstract: Background: Comparative studies have shown the correlation between sepsis, septic shock and red blood cell distribution width (RDW) in the adult population. There is limited information about the association between RDW and neonatal sepsis.

Cited by 2 publications

References 22 publications

Presepsin level as risk factor for mortality in premature infants with neonatal sepsis

Presepsin level as risk factor for mortality in premature infants with neonatal sepsis

A study of red cell distribution width and neonatal sepsis at Soba University Hospital, Khartoum, Sudan

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