Relationship between electrocardiogram changes and myocardial edema in tako-tsubo syndrome

Abstract

Introduction During the acute phase of Tako-tsubo syndrome (TTS) electrocardiogram (ECG) features change and myocardial edema is a common finding in Cardiac Magnetic Resonance (CMR). However, the relationship between ECG changes and myocardial edema is still unclear. Purpose To define if the presence and extension of myocardial edema might be predicted by electrocardiographic changes since admission to CMR. Methods Consecutive patients with TTS undergoing CMR during hospitalization were included. All patients underwent serial electrocardiography during the acute phase. Myocardial edema presence and extension was assessed by expert observers using the 17-segments cardiac segmentation model. ECG were analysed by expert observers blinded to the presence of myocardial edema. ECG pattern as predictors of myocardial edema presence and its extension were analysed by a binary regression and Student's t test. Results A total of 42 patients were included. Admission cQT was 472±60 ms. Thirty patients (71%) developed widespread negative T-waves and 55% showed cQT prolongation (cQT 476±58 ms) by the time of CMR. The median (IQR) time from admission to CMR imaging was 5 days (2–7 days). Myocardial edema was found in 30 patients (71%) and mean number of myocardial segments affected by edema was 4.8±2.5. Widespread negative T-wave development at the time of CMR imaging was associated with a smaller number of myocardial segments with edema. However no significant correlation was found between extension of myocardial edema and QT prolongation. No ECG pattern predicted a full recovery of myocardial edema (Table). Conclusions Development of widespread negative T-wave at the time of CMR predicts smaller myocardial edema extension. However, no other ECG features by the time of CMR were able to predict the full recovery of myocardial edema. Funding Acknowledgement Type of funding source: None