2017
DOI: 10.1159/000471884
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Relationship between Elevated Intraocular Pressure and Divided Peripapillary Sector Retinal Nerve Fiber Layer Thickness in a Cynomolgus Monkey Laser-Induced Ocular Hypertension Model

Abstract: Aims: We investigated the relationship between elevated intraocular pressure (IOP) and changes in global and peripapillary sector retinal nerve fiber layer (RNFL) thickness around the optic nerve head (ONH) in the laser-induced ocular hypertension monkey model. Methods: To induce high IOP, green laser photocoagulation burns were applied around the trabecular meshwork of 1 eye from each of 12 cynomolgus monkeys. The animals had been acclimated to IOP measurement under conscious conditions for more than 2 months… Show more

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Cited by 9 publications
(9 citation statements)
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“…Correlations between cumulative IOP increase and RNFL thickness reduction were statistically significant for the temporal-superior ( p =0.024), nasal-inferior ( p =0.044), and temporal ( p =0.049) sectors. 35 …”
Section: Discussionmentioning
confidence: 99%
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“…Correlations between cumulative IOP increase and RNFL thickness reduction were statistically significant for the temporal-superior ( p =0.024), nasal-inferior ( p =0.044), and temporal ( p =0.049) sectors. 35 …”
Section: Discussionmentioning
confidence: 99%
“…The prospective cohort study consisted of 69 subjects (122 eyes), 32 males (6x one, 26x both eyes) aged 21 to 76 years and 37 females (4x one and 30x both eyes) aged 22 to 75 years, who were measured to have IOP greater than 21 mmHg (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) in routine ambulatory care. IOP was the result of the average of three measurements with the Ocular Response Analyser (ORA).…”
Section: Methodsmentioning
confidence: 99%
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“…Quantitative retinal layer thickness measurements could provide important information for retinal disease detection and diagnosis. Many studies have shown a wide range of eye diseases can lead to thickening of the retina (Bandello et al, ; Leung et al, ; Noguchi et al, ; Rovere et al, ; Tejerina et al, ). Our finding indicates that compared with histological images, DPC‐microCT can be used as a more reliable tool in detecting retinal thickness changes.…”
Section: Discussionmentioning
confidence: 99%
“…RNFL thickness changed differently with elevated intraocular pressure (IOP) among peripapillary sectors. The temporal-superior, nasal-inferior, and temporal sectors showed the greatest decline and were thought to be more sensitive to elevated IOP, which could be used to detect glaucomatous damage to RNFL thickness [ 94 ]. Suić et al [ 95 ] found that there was a considerable decline in inferior RNFL thickness in people with ocular hypertension.…”
Section: Other Confoundersmentioning
confidence: 99%