Relationship Between Endoscopic and Clinical Disease Activity With Fatigue in Inflammatory Bowel Disease

Kamp, Kendra; Clark‐Snustad, Kindra; Barahimi, Mitra; Lee, Scott

doi:10.1097/sga.0000000000000600

Cited by 3 publications

(3 citation statements)

References 40 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Liu et al [21] found no statistically significant differences in CDAI scores among CD patients in different age groups. Similarly, a study by Kamp et al [22] on the correlation between disease activity and fatigue in inflammatory bowel disease patients did not find an impact of age. Although our study results differ from previous research, this discrepancy may be attributed to various factors, including sample size, study design, and differences in study populations.…”

Section: Relationship Between Age and Disease Activity In CD Particip...mentioning

confidence: 85%

Influential factors on disease activity in Crohn’s disease and their Roc curve evaluation: a cross-sectional study

Wang,

Tong,

2024

BMC Gastroenterol

View full text Add to dashboard Cite

Objective This study aims to investigate the factors influencing disease activity in patients with Crohn’s disease (CD) and provide insights and references for the management and prevention of CD. Methods We recruited CD patients who met the inclusion and exclusion criteria and were treated at the First Affiliated Hospital of Soochow University from November 2022 to June 2023. Generalized linear mixed models were used to analyze the factors affecting disease activity in CD patients. Receiver operating characteristic (ROC) curve analysis was employed to assess the predictive value of these factors for disease activity. Results A total of 268 CD participants aged 18 to 65 were included in the study, with over 68% of them in remission or experiencing mild disease activity, indicating relatively good disease control. The results of the generalized linear mixed models showed that older age, absence of diabetes, high levels of physical activity, and a low dietary inflammatory index (DII) were protective factors for lower disease activity in CD patients (p < 0.05). ROC curve analysis demonstrated that physical activity level, age, and DII all had ROC areas greater than 0.6 in predicting disease activity in CD patients (p < 0.05). Conclusion The factors influencing the disease activity of CD patients are numerous and should be given attention. CD patients who are younger, have low levels of physical activity, high DII, and have diabetes are at a higher risk of increased disease activity. By reducing or avoiding the mentioned risk factors and leveraging protective factors, it is possible to mitigate the disease activity of CD to some extent.

show abstract

Section: Relationship Between Age and Disease Activity In CD Particip...mentioning

confidence: 85%

Influential factors on disease activity in Crohn’s disease and their Roc curve evaluation: a cross-sectional study

Wang,

Tong,

2024

BMC Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Based on published literature and our prior work in chronic pain populations, morning light treatment has the potential to improve not only mood and sleep in IBD, but also improve gastrointestinal symptoms and possibly even intestinal inflammation. Even if morning light treatment were to only improve mood and sleep in patients with IBD, this treatment would assist at least 50% of IBD patients who suffer from such symptoms [4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with IBD suffer from relapsing and remitting flares with gastrointestinal symptoms such as diarrhea, rectal bleeding, and abdominal pain as well as extraintestinal symptoms such as sleep and mood disturbances [3]. In fact, an estimated 56% of IBD patients report poor sleep quality [4] and mood disorders such as depression affects at least 20-30% of patients with IBD [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Morning light treatment for inflammatory bowel disease: a clinical trial

Cohen-Mekelburg,

Goldstein,

Rizvydeen

et al. 2024

BMC Gastroenterol

View full text Add to dashboard Cite

Background Inflammatory bowel disease (IBD) affects over 3 million Americans and has a relapsing and remitting course with up to 30% of patients experiencing exacerbations each year despite the availability of immune targeted therapies. An urgent need exists to develop adjunctive treatment approaches to better manage IBD symptoms and disease activity. Circadian disruption is associated with increased disease activity and may be an important modifiable treatment target for IBD. Morning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, but no studies have explored these potential therapeutic benefits in IBD. Therefore, in this study, we aim to test the effectiveness of morning light treatment for patients with IBD. Methods We will recruit sixty-eight individuals with biopsy-proven IBD and clinical symptoms and randomize them to 4-weeks of morning light treatment or 4-weeks of treatment as usual (TAU), with equivalent study contact. Patient-reported outcomes (IBD-related quality of life, mood, sleep), clinician-rated disease severity, and a biomarker of gastrointestinal inflammation (fecal calprotectin) will be assessed before and after treatment. Our primary objective will be to test the effect of morning light treatment versus TAU on IBD-related quality of life and our secondary objectives will be to test the effects on clinician-rated disease activity, depression, and sleep quality. We will also explore the effect of morning light treatment versus TAU on a biomarker of gastrointestinal inflammation (fecal calprotectin), and the potential moderating effects of steroid use, restless leg syndrome, and biological sex. Discussion Morning light treatment may be an acceptable, feasible, and effective adjunctive treatment for individuals with active IBD suffering from impaired health-related quality of life. Trial registration The study protocol was registered on ClinicalTrials.gov as NCT06094608 on October 23, 2023, before recruitment began on February 1, 2024.

show abstract

Deficits in geriatric assessment are important in relation to fatigue in older patients with Inflammatory Bowel Disease

Fons,

Asscher,

Stuyt

et al. 2024

Digestive and Liver Disease

View full text Add to dashboard Cite

Relationship Between Endoscopic and Clinical Disease Activity With Fatigue in Inflammatory Bowel Disease

Cited by 3 publications

References 40 publications

Influential factors on disease activity in Crohn’s disease and their Roc curve evaluation: a cross-sectional study

Influential factors on disease activity in Crohn’s disease and their Roc curve evaluation: a cross-sectional study

Morning light treatment for inflammatory bowel disease: a clinical trial

Deficits in geriatric assessment are important in relation to fatigue in older patients with Inflammatory Bowel Disease

Contact Info

Product

Resources

About