Relationship between epicardial adipose tissue and prognosis of cardiovascular events

Лосик, Д. В.; Nikitin, Nikita; Минин, С. М.; Fisher, EW; Mikheenko, I.; Chernyavsky, Alexander; Romanov, Alexander

doi:10.17116/kardio202114041253

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…В нашем исследовании было показано, что у пациентов с ХСН есть достоверные различия в объеме периатриального и общего ЭЖТ в зависимости от формы ФП. В связи с активным применением методов КТ в диагностике сердечно-сосудистых заболеваний в последние годы стали активно изучать влияние и изменения объемов ЭЖТ при различных клинических состояниях [16,17]. Так, исследование под руководством Beyer C продемонстрировало прогностическую значимость объема ЭЖТ у пациентов после катетерной аблации по поводу ФП.…”

Section: характеристика кардиоспецифических биомаркеров и показателей...unclassified

The role of cardiac biomarkers and epicardial fat in the diagnosis of heart failure in patients with various types of atrial fibrillation

et al. 2022

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Aim. To assess the level of various cardiac biomarkers and the volume of epicardial adipose tissue (EAT) in patients with heart failure (HF) depending on the type of atrial fibrillation (AF).Material and methods. This prospective observational study included 69 patients with symptomatic AF, as well as with manifestations of New York Heart Association (NYHA) class II-III HF. All patients were examined before catheter ablation for AF. The following investigations were performed: echocardiography, computed tomography, myocardial perfusion scintigraphy, immunochemical analysis of cardiac biomarkers (brain natriuretic peptide (BNP), high-sensitivity troponin I (hs-TnI)), as well as biochemical analysis of high-sensitivity C reactive protein (hsCRP). Patients were divided into 2 groups, depending on the AF type, into paroxysmal and non-paroxysmal (persistent and long-standing persistent).Results. The analysis included 69 patients with various AF types and symptomatic HF. There were significantly more patients with HF confirmed by an elevated BNP level in the group with non-paroxysmal type (27 (71%) vs 5 (16%), p<0,00001). Comparison analysis showed that in group 2 the mean BNP level was significantly higher than in group 1 (135,5 pg/ml [75,2;303,2] vs 40 pg/ml [20,7;56,9], respectively, p<0,00001). The hs-TnI level was higher in group 2 (2,5 [1,7;5,1] vs 1,9 [0,8;3,9], respectively, p=0,19), but there was no significant difference between the groups. The level of hsCRP did not differ in both groups. In group 1, the EAT volume was 139 [117,5;171] vs 169 [130;209,5] in group 2 (p=0,03).Conclusion. The type of AF plays a role in the interpretation of cardiac specific enzymes, and BNP levels and EAT volume are higher in patients with the non-paroxysmal form.

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Section: характеристика кардиоспецифических биомаркеров и показателей...unclassified

The role of cardiac biomarkers and epicardial fat in the diagnosis of heart failure in patients with various types of atrial fibrillation

et al. 2022

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“…Всем пациентам выполняли коронароангиографию на ангиографическом аппарате INNOVA 3100 (США) при наличии III ФК стенокардии, нарастании клинических проявлений стенокардии или ее эквивалентов, наличии суммарной оценки гипоперфузии миокарда ≥10% по результатам визуализирующих методик, положительный 20% сердечной массы, однако увеличение ее объема запускает патологические механизмы, которые связаны с вазокринной или паракринной секрецией провоспалительных адипокинов и свободных жирных кислот, чему способствует отсутствие фасций, разделяющих ЭЖТ и миокард [3].…”

Section: Introductionunclassified

“…1 , Лукинов В. Л. 3 1 ФГБОУ ВО "Новосибирский государственный медицинский университет" Минздрава России. Новосибирск; 2 ГБУЗ Новосибирской области "Новосибирский областной клинический кардиологический диспансер".…”

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“…Новосибирск; 2 ГБУЗ Новосибирской области "Новосибирский областной клинический кардиологический диспансер". Новосибирск; 3 ФГБУН "Институт вычислительной математики и математической геофизики Сибирского отделения РАН". Новосибирск, Россия Цель.…”

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Anxiety-depressive disorders in patients with coronary artery disease with borderline coronary artery stenosis and visceral obesity

Yakhontov,

Ostanina,

Dunicheva

et al. 2024

Cardiovasc Ther Prev

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Aim. To assess the prevalence of anxiety-depressive disorders in patients with coronary artery disease (CAD) with borderline coronary artery (CA) stenosis and visceral obesity.Material and methods. The study involved 201 patients with stable CAD with class I-III angina pectoris with borderline (50-70%) coronary stenosis. The first group consisted of patients with stable borderline CAD with increased epicardial fat thickness (EFT) — 57 (28,4%) people, the second group — patients without increased EFT — 144 (71,6%) people. Blood biochemical tests, levels of inflammatory markers (high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, tumor necrosis factor alpha, N-terminal pro-brain natriuretic peptide) were assessed. Cardiac ultrasound was used to determine EFT. All patients underwent coronary angiography. Levels of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS).Results. The average EFT in group 1 was 6,00 [5,00; 6,50] mm, in group 2 — 3,00 [2,30; 4,00] mm (p<0,001). In group 1 patients, hypertension (p<0,001), coronary artery disease (p<0,001) in general and myocardial infarction (p=0,003) in particular debuted at a younger age. The groups did not differ significantly in the incidence of obesity, type 2 diabetes, functional class of angina, or the intake rate of all 4 main drug groups. Patients with increased EFT were more likely to have elevated levels of N-terminal pro-brain natriuretic peptide (p=0,002), high-sensitivity C-reactive protein (p=0,027), as well as higher values (p=0,005) and a higher frequency of increasing (p<0,001) the antiinflammatory cytokine IL-10. When analyzing the anxiety-depressive profile, the sum of depression scores and the incidence of subclinical depression were significantly (p<0,001) higher in the group of patients with increased EFT.Conclusion. Patients with stable CAD with borderline coronary artery stenosis and increased EFT, which is a marker of visceral obesity, are characterized by an earlier age of manifestation of hypertension and coronary artery disease, the presence of a pro-inflammatory phenotype and a higher level of subclinical depression.

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Problems and prospects of medical care for obese patients

Monisov,

Rugol,

Zaletova

2024

Rus. J. Prev. Med.

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Relationship between epicardial adipose tissue and prognosis of cardiovascular events

Cited by 4 publications

References 20 publications

The role of cardiac biomarkers and epicardial fat in the diagnosis of heart failure in patients with various types of atrial fibrillation

The role of cardiac biomarkers and epicardial fat in the diagnosis of heart failure in patients with various types of atrial fibrillation

Anxiety-depressive disorders in patients with coronary artery disease with borderline coronary artery stenosis and visceral obesity

Problems and prospects of medical care for obese patients

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