Introduction: Epistaxis is the most common otorhinolaryngological emergency. Whether there is an association relationship between epistaxis and hypertension is a subject of longstanding controversy. Objective: The aim of our study is to evaluate the relationship between epistaxis and hypertension. Materials and methods: This study was conducted at,U.P during the period between June 2016 and January 2017. A total of 40 patients were divided into two groups: Group A consisted of 20 patients who presented with epistaxis, and Group B consisted of 20 patients who served as a control group. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed for all patients. Patients were followed up for a period of two months. Results: Readings of blood pressure (BP) were similar between the two groups regarding BP at presentation, ABPM, and BP at two months. There was a higher number of attacks in patients with history of hypertension. There was highly significant positive correlation between number of attacks of epistaxis and BP readings. Systolic BP at presentation was higher in patients who needed more complex interventions such as pack or cautery than those managed by first aid. Conclusion: We found no definite association between epistaxis and hypertension.