Relationship between epstein-barr virus and lymphoepithelioma-like carcinoma of the lung: A clinicopathologic study of 6 cases and review of the literature

Castro, Claudia Y.; Ostrowski, Mary L.; Barrios, Roberto; Green, Linda K.; Popper, H.; Powell, Suzanne Zein-Eldin; Cagle, Phillip T.; Ro, Jae Y.

doi:10.1053/hupa.2001.26457

Cited by 134 publications

(100 citation statements)

References 66 publications

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“…13,12 However, the neoplastic cells had an extremely low 7 LMP1 expression, and in situ hybridization for EBV early RNA (EBER) and clonal episomal EBV sequences have been demonstrated in tumour tissue, but only in Asian 9,23,12,25,26 and in two caucasic patients. 18,19 We agree with these data because our five cases of pure lymphoepitheliomalike carcinomas have been negative for EBV.…”

Section: Discussionmentioning

confidence: 99%

“…It is defined as an undifferentiated carcinoma that shows a typical syncytial growth pattern of undifferentiated neoplastic epithelial cells, with vesicular nuclei and prominent nucleoli, similar to the nasopharynx counterpart. 5 Primary lymphoepithelioma-like carcinoma of the lung is very rare and most of reports come from Chinese or Taiwanese patients, [6][7][8] and to date the association of EBV with these kind of lung carcinomas is restricted to Asian patients 9,10 (Table 1).…”

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confidence: 99%

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Epstein–Barr virus-associated adenocarcinomas and squamous-cell lung carcinomas

et al. 2009

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The association of Epstein-Barr virus with pulmonary neoplasms has been restricted to lymphoepithelioma-like carcinomas in Asian patients. We have selected 19 pulmonary adenocarcinomas and squamous-cell carcinomas from 1545 pulmonary neoplasms diagnosed from 1996 to 2007 in an occidental population. All of them showed a low-power appearance confusing between an epithelial and a lymphoid neoplasm, with a dense lymphocytic infiltrate intermingled with neoplastic cells giving an image akin to lymphoepithelial complexes. Five carcinomas presented typical features of Lymphoepithelioma-like lung carcinomas; but six cases could be classified as squamous-cell carcinomas and eight as adenocarcinomas. A semiquantitative polymerase chain reaction method, Early RNA genes 1 and 2 in situ hybridization as well as Latent membrane protein immunostaining for Epstein-Barr virus DNA, RNA and protein detection methods were used in every case. None of Lymphoepithelioma-like carcinomas showed positivity for Epstein-Barr virus in any used method. Otherwise four squamous-cell carcinomas and eight adenocarcinomas (12 cases) demonstrated viral sequences in polymerase chain reaction and/or in situ hybridization analysis in neoplastic cells. Moreover two adenocarcinomas also displayed human herpesvirus 6 DNA sequences coamplification in molecular analysis. Protein immunostaining was focally positive in only three cases. We performed the same analysis in 70 more cases of conventional pulmonary squamous-cell carcinomas and adenocarcinomas that gave negative results. In conclusion, a subset of pulmonary squamous-cell carcinomas and adenocarcinomas show Epstein-Barr DNA and/or RNA sequences in neoplastic cells. This finding expands the spectra of epithelial cell common tumours Epstein-Barr virus associated.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Epstein–Barr virus-associated adenocarcinomas and squamous-cell lung carcinomas

et al. 2009

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“…Latent EBV infection has been implicated in the pathogenesis of both NPC and LELC. However, the carcinogenesis of LELC is still debated and the association with EBV is variable [11]. Most of the literature is published on the Asian population.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Lymphoepithelioma-like Carcinoma on FDG PET/CT

Aktaş

Can

Demir

et al. 2016

Nucl Med Mol Imaging

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A 69-year-old male smoker was referred to 18 Ff l u o r o d e o x y g l u c o s e ( F D G ) p o s i t r o n e m i s s i o n tomography-computed tomography (PET/CT) with the indication of a suspicious solitary pulmonary nodule. FDG PET/CT determined a 2.5 × 2-cm soft-tissue lesion (SUVmax, 16.2) with spiculated margins in the hilum of the right lung. A 1-cm diameter lymphadenopathy on the right hilum with an SUVmax of 3.2 was also determined. Transbronchial biopsy of the right hilar lymphadenopathy did not reveal any malignant features in histopathologic examination, and it was determined to be reactive. The patient underwent a right upper lobe segmentectomy, and the histopathologic evaluation revealed that the tumor was a primary lymphoepithelioma-like carcinoma (LELC) of the lung with negative Epstein-Barr virus (EBV) on in situ hybridization studies. In this case report, we mainly focus on the FDG avidity of this very rare kind of tumor comparatively with previous reports and possible explanations of discordancy in FDG avidity in relation to histopathologic characteristics.

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“…5 In contrast to the non small cell carcinomas of the lung, primary LELC has been found to have minimal association with cigarette smoking. 5,8,9 Metastasis tends to occur less frequently and late in the course of primary LELC. 4,10 As per the data of two large case series, about one-third of the patients were asymptomatic at the time of the diagnosis.…”

Section: Discussionmentioning

confidence: 99%