Relationship between estimated glomerular filtration rate and biological half-life of 131I

Abstract

Summary Aim: This retrospective study sought to investigate the relationship between biological half-life (t 1/2 biol ) of 131I and estimated glomerular filtration rate (eGFR) in patients with thyroid carcinoma. Patients, methods: 96 patients with differentiated thyroid carcinoma (69 women, 27 men, mean age 64.0 ± 13.6 years) and diagnostic and therapeutic administration of 131I were considered. Patients with pronounced specific iodine storage were not included in the study. The eGFR was estimated according to the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula, the t 1/2 biol via dosimetry. Patients were subdivided in groups with normal clearance (NC) (n = 37, 38.5%), medium clearance (MC) (n = 48, 50.0%), and low clearance (LC) (n = 11, 11.5%) (eGFR _ 90; 60-89; 15-59 ml/min per 1.73 m2, respectively). The relationship between eGFR and t 1/2 biol of 131I was modeled using a power function. Results: The groups significantly differed in terms of age (NC 53.8, MC 68.6, and 78.0 years, respectively), serum creatinine levels (NC: 0.71; MC: 0.85; LC: 1.18 mg/dl), and t 1/2 biol (NC: 0.53; MC: 0.71; LC: 1.01 days). The t 1/2 biol was significantly influenced only by eGFR, and not by age, gender, or body weight. The relationship between t 1/2 biol of 131I and eGFR was described by the formula t 1/2 biol = 20.3 · eGFR−0.782. Conclusions: The calculated relationship between renal function and t 1/2 biol of 131I can be used in principle to estimate a dose reduction for patients with renal insufficiency. The model, however, gives erroneous results in individual cases and therefore a routine utilization cannot be recommended. Prospective studies are necessary, based on larger patient numbers and more accurate methods for dose rate measurement and GFR.

Urine concentrating ability in cats with hyperthyroidism: Influence of radioiodine treatment, masked azotemia, and iatrogenic hypothyroidism

“…68,69 Therefore, lowered doses of 131 I are generally recommended for human patients with known renal disease to help prevent overdosing with 131 I. [68][69][70] Although further studies of concurrent renal disease as a risk factor for 131 I-induced hypothyroidism are needed, lowering the administered 131 I dosage should be considered in hyperthyroid cats that have pretreatment USG <1.035, especially if they also have other known risk factors for 131 I-induced hypothyroidism. 37 This study had several limitations.…”

“…Since iodine (and therefore 131 I) is removed from the body primarily by renal excretion, 65,66 kidney disease can lead to decreased clearance and increased retention of 131 I, an effect which has been known for over 70 years 67 . The thyroid gland of patients with renal disease can continue to take up 131 I for a longer time than do those without renal disease, because they are presented with higher circulating concentrations of 131 I for a longer time 68,69 . Therefore, lowered doses of 131 I are generally recommended for human patients with known renal disease to help prevent overdosing with 131 I 68‐70 .…”

“…67 The thyroid gland of patients with renal disease can continue to take up 131 I for a longer time than do those without renal disease, because they are presented with higher circulating concentrations of 131 I a longer time. 68,69 Therefore, lowered doses of 131 I are generally recommended for human patients with known renal disease to help prevent overdosing with 131 I. [68][69][70] Although further studies of concurrent renal disease as a risk factor for 131 I-induced hypothyroidism are needed, lowering the administered 131 I dosage should be considered in hyperthyroid cats that have pretreatment USG <1.035, especially if they also have other known risk factors for 131 I-induced hypothyroidism.…”

Relationship between Whole Body Iodine-131 Effective Half-Life and Estimated Glomerular Filtration Rate for Papillary Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

“…Estimated glomerular filtration rate (eGFR) is used in clinical practice to exam renal function status of patients [9]. The body surface area was calculated using the DuBois formula [10].…”