Relationship Between Ethanol-Related Diseases and Nutritional Status in Chronically Alcoholic Men

Estruch, Ramón; Nicolás, José M.; Villegas, Eulalia; Junqué, A.; Urbano-Márquez, Á

doi:10.1093/oxfordjournals.alcalc.a045431

Cited by 34 publications

(6 citation statements)

References 22 publications

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“…Some of earliest recognized disturbances are the histological, biochemical, and physiological alterations observed in skeletal muscle (6)(7)(8)(9). In fact, 40%-60% of chronic alcoholics develop alcoholic myopathy, a disorder defined as loss of muscle strength and size that results from excessive alcohol intake (10)(11)(12)(13). Chronic alcoholic myopathy is often characterized by muscle atrophy and weakness that occurs over years of sustained drinking (10,14,15).…”

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confidence: 99%

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Moser

Brown

Ganjayi

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Alcoholics develop muscle atrophy and weakness from excessive ethanol (EtOH) intake. To date, most research has examined outcomes of alcohol-induced atrophy and weakness under basal or unstressed conditions despite physical stress being a normal occurrence in a physiological setting. Therefore, this study set out to determine if recovery of torque is impaired after repetitive bouts of physical stress in skeletal muscle during excessive short-term (experiment 1) and long-term (experiment 2) EtOH consumption. Methods: Twenty male and female mice were assigned to receive either 20% EtOH in their drinking water or 100% water. Short-and long-term consumption was predetermined to be EtOH intake starting at 4 and 26 wk, respectively. Anterior crural muscles performed repeated bouts of physical stress using in vivo eccentric contractions, with tetanic isometric torque being measured immediately pre-and postinjury. A total of 10 bouts were completed with 14 d between each bout within bouts 1-5 (experiment 1) and bouts 6-10 (experiment 2), and 12 wk between bouts 5 and 6. Results: Mice consuming EtOH had blood alcohol concentrations up to 270 mg•dL −1 . In experiment 1, five bouts of eccentric contractions did not reduce recovery of torque, regardless of sex or EtOH treatment (P ≥ 0.173). Similarly, in experiment 2, preinjury torques did not differ from day 14 values regardless of sex or treatment (P ≥ 0.322). However, there was a group effect in female mice for bouts 6 and 10 during experiment 2, with female EtOH mice being weaker than controls (P ≤ 0.002). Conclusions: Excessive short-or long-term EtOH misuse in a mouse model did not affect the muscle's ability to regain strength after repeated bouts of eccentric contractions, suggesting that EtOH may not be as detrimental to recovery as once predicted.

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confidence: 99%

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Moser

Brown

Ganjayi

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Concerning a direct toxic effect, several studies reported a link between alcohol consumption (disease duration, alcohol intake, drinking pattern) and incidence of neuropathy. 7 The most frequently reported risk factor is TLDE 44,[46][47][48][49][50] with an inverse correlation between TLDE and sural nerve amplitude. 6 In our study, TLDE was not correlated with neuropathy severity (neither NDS nor thermal thresholds) as reported also in other prior studies.…”

Section: Discussionmentioning

confidence: 99%

Somatosensory profiling of patients undergoing alcohol withdrawal: Do neuropathic pain and sensory loss represent a problem?

Fernandez

Graf

Lasserre

et al. 2023

J Peripheral Nervous Sys

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IntroductionChronic heavy alcohol use is known to cause neurological complications such as peripheral neuropathy. Concerning the pathophysiology, few sural nerve and skin biopsy studies showed that small fibers might be selectively vulnerable to degeneration in alcohol‐related peripheral neuropathy. Pain has rarely been properly evaluated in this pathology. The present study aims at assessing pain intensity, potential neuropathic characteristics as well as the functionality of both small and large nerve sensitive fibers.MethodsIn this observational study, 27 consecutive adult patients, hospitalized for alcohol withdrawal and 13 healthy controls were recruited. All the participants underwent a quantitative sensory testing (QST) according to the standardized protocol of the German Research Network Neuropathic Pain, a neurological examination and filled standardized questionnaires assessing alcohol consumption and dependence as well as pain characteristics and psychological comorbidities.ResultsNearly half of the patients (13/27) reported pain. Yet, pain intensity was weak, leading to a low interference with daily life, and its characteristics did not support a neuropathic component. A functional impairment of small nerve fibers was frequently described, with thermal hypoesthesia observed in 52% of patients. Patients with a higher alcohol consumption over the last 2 years showed a greater impairment of small fiber function.DiscussionPatients report pain but it is however unlikely to be caused by peripheral neuropathy given the non‐length‐dependent distribution and the absence of neuropathic pain features. Chronic pain in AUD deserves to be better evaluated and managed as it represents an opportunity to improve long‐term clinical outcomes, potentially participating to relapse prevention.

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“…It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism (Estruch et al, 1993), the most significant of which are disturbances in the dynamics of muscle contraction (Nozdrenko & Bogutska, 2005). Currently, exogenous antioxidants are used in the treatment of muscle pathologies of various nature.…”

Section: Introductionmentioning

confidence: 99%

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

Nozdrenko,

Nan,

Motuziuk

et al. 2024

Biol. Stud.

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Background. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on the contraction parameters of damaged muscles has been established. In addition, administration of C60 fullerene aqueous solution during chronic alcoholization of rats protects muscle tissue from damage caused by oxidative stress. Materials and Methods. Biomechanical parameters such as the values of the minimum and maximum contraction force and the muscle force impulse were evaluated using tensometry. The blood levels of creatine phosphokinase and lactate dehydrogenase, creatinine and lactate as well as the level of oxidative processes in muscle tissue of experimental animals (content of hydrogen peroxide, activity of catalase, glutathione peroxidase and superoxide dismutase) as markers of muscle damage were determined using methods of biochemical analysis. Results. The C60 fullerene aqueous solution effect on the skeletal muscle contraction dynamics in rats after chronic alcoholization for 9 months and cessation of alcohol consumption for 1 month was investigated. It was established that water-soluble C60 fullerenes (daily dose of 1 mg/kg) reduce the effects of chronic alcoholization by 35–40±2 % on the studied biomechanical parameters and by 20±1 % on the studied biochemical parameters compared to the group of alcoholized animals, thus increasing the energy capabilities of the muscular system. Conclusions. The obtained data indicate a pronounced protective effect of C60 fullerenes on the muscle soleus contraction dynamics during the development of alcoholic myopathy, which opens up the potential possibility of their use for the prevention and correction of miotic damage.

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Relationship Between Ethanol-Related Diseases and Nutritional Status in Chronically Alcoholic Men

Cited by 34 publications

References 22 publications

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Excessive Ethanol Intake in Mice Does Not Impair Recovery of Torque after Repeated Bouts of Eccentric Contractions

Somatosensory profiling of patients undergoing alcohol withdrawal: Do neuropathic pain and sensory loss represent a problem?

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

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