Relationship between exposure duration, tissue residues, growth, and mortality in rainbow trout (Oncorhynchus mykiss) juveniles sub-chronically exposed to copper

Hansen, James A.; Lipton, Joshua; Welsh, Paul G.; Morris, Jeffrey M.; Cacela, Dave; Suedkamp, Michael J.

doi:10.1016/s0166-445x(01)00234-x

Cited by 61 publications

(33 citation statements)

References 16 publications

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“…Hansen et al (2002) observed 20% and 33% reductions in growth rates in rainbow trout Oncorhynchus mykiss exposed to 22.2 and 54.1 µg/L of Cu, respectively, over 56 days. Similarly, Seim et al (1984) observed that fish exposed to 31 µg/L Cu were approximately flounder was approximately 23 and 34 times higher in the 150 and 320 µg/L Cu exposure groups, respectively, compared to the control diet group.…”

Section: Discussionmentioning

confidence: 87%

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

Kim¹,

Jang²,

Lee³

et al. 2011

Fisheries and aquatic sciences

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Olive flounder, Paralichthys olivaceus were exposed to waterborne Cu (control, 50, 80, 150, and 320 µg/L) for 30 days and then depurated for 20 days to investigate the effects of waterborne Cu exposure on growth, accumulation, and elimination. The weightspecific growth rate was significantly negatively related to waterborne Cu concentrations at 150 and 320 µg/L. The order of Cu accumulation in different tissues of exposed fish was liver>intestines>gills>kidneys>muscle, suggesting that the liver is more important than other tissues for the storage of Cu in olive flounder. The accumulation factor for the gills, intestines, liver, and muscle increased with increasing exposure time, and accumulation was negatively related to exposure concentration for the gills, kidneys, and muscle. Cu concentrations in the gills, intestines, and liver continuously decreased for 20 days of depuration. The fastest elimination rate occurred in the intestines at all exposure concentrations, and the order of Cu elimination in the different tissues was intestines>liver>gills.

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Section: Discussionmentioning

confidence: 87%

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

Kim¹,

Jang²,

Lee³

et al. 2011

Fisheries and aquatic sciences

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“…Although several studies investigated the acclimation process, using for example survival parameters (Hansen et al, 2002), this study is first to address the issue of acclimation to a metal in fish endocrine cells. When cells were exposed in vitro to Cu, cortisol secretion was reduced in fish from all the in vivo treatments, in controls and in fish pre-exposed to Cu for 30 days.…”

Section: Discussionmentioning

confidence: 99%

“…Other investigators demonstrated that acclimation to Cu enhances tolerance to acute challenges with Cu and other metals, partly through metallothionein induction (Carvalho et al, 2004;van Heerden et al, 2004). Hansen et al (2002) reported that while naïve trout suffered over 80% mortality when subjected to an acute 96 h challenge with 91 g/l Cu, trout acclimated to 36 g/l Cu for 56 days suffered only 20% mortality when challenged. Although it is known that liver, gill and the gut are the organs that mediate acclimation to Cu (Kamunde et al, 2002;Niyogi and Wood, 2003), how the acclimation processes influence sensitivity to Cu in other tissues has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cu on plasma cortisol and cortisol secretion by adrenocortical cells of rainbow trout (Oncorhynchus mykiss)

2006

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Fish are exposed to multiple stressors, often acting concurrently, in their environment. To evaluate the potential of Cu to act as a chemical stressor, rainbow trout (Oncorhynchus mykiss) were exposed to Cu (30 or 80 g/l) for 30 days in the laboratory and they were subjected to a physical stressor (1 min air exposure) before sampling. Physiological stress indicators in the whole fish as well as cortisol secretion by adrenocortical cells in vitro were measured. Fish exposed to Cu had a lower condition factor, hepatosomatic index, plasma glucose, hepatic glycogen and gill Na + /K + -ATPase activity compared to controls. Exposure to Cu did not have an effect on basal plasma cortisol (fish sampled without air exposure stress) however, the air exposure-induced increase in plasma cortisol was lower in fish exposed to Cu. Cortisol secretion stimulated by ACTH in vitro was greater in adrenocortical cells isolated from fish exposed to Cu in vivo but in vitro exposure to Cu consistently impaired cortisol secretion. Our results indicate that Cu at high concentrations disrupts cortisol secretion through a direct toxic effect on adrenocortical cells while low concentrations resulting from a 30-day exposure to environmentally relevant Cu concentrations enhances cortisol secretion in response to ACTH in vitro.

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“…Metal acclimation has been defined as the ability to tolerate typically lethal metal exposures while maintaining normal physiological function (McDonald and Wood, 1993). Development of the acclimatory response has been shown to be dependant upon exposure time (Marr et al, 1995;Sellin et al, 2005) and exposure concentration (Dixon and Sprague, 1981;Benson and Birge, 1985;Taylor et al, 2000;Hansen et al, 2002). This study further investigates the relationship between metal concentration and the development of enhanced tolerance specifically focusing on the development of enhanced tolerance in juvenile fathead minnows exposed to different exposure doses of Cu.…”

Section: Introductionmentioning

confidence: 99%

“…Reductions in mortality have been used previously to infer enhanced Cu tolerance in rainbow trout (Dixon and Sprague, 1981;Taylor et al, 2000;Hansen et al, 2002) and fathead minnows (Sellin et al, 2005). Likewise, the ability of fish to maintain physiologically normal levels of whole-body Na + has also been used to infer enhanced Cu tolerance in rainbow trout and fathead minnows (Laurén and McDonald, 1987a;Kolok et al, 2002;Croke and McDonald, 2002).…”

Section: Introductionmentioning

confidence: 99%

Copper acclimation in juvenile fathead minnows: Is a cycle of branchial damage and repair necessary?

Tate-Boldt

Kolok

2008

Aquatic Toxicology

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Fathead minnows exposed to sublethal Cu concentrations may undergo branchial damage followed by repair, and may also develop enhanced Cu tolerance. The primary objective of this study was to determine whether the cycle of damage and repair was necessary for the development of enhanced Cu tolerance. Inferences regarding damage and repair were made from changes in the whole body Na + of juvenile (0.5 g) fathead minnows (Pimephales promelas). Two experiments were conducted in which juvenile minnows were exposed to various sublethal Cu concentrations for 16 d. In the first experiment, fish were exposed to one of four different Cu concentrations (0, 73, 118, 189 μg/L Cu) then challenged with an 8-d exposure at 302 μg Cu/L. Only the fish exposed to the highest Cu dose experienced enhanced Cu tolerance relative to the other three doses. In the second experiment, whole body Na + was monitored in fish exposed to one of five different Cu exposures (0, 70, 127, 202, 289 μg/L Cu). Fish exposed to 70 μg/L Cu did not experience a significant decline in whole body Na + at any point during the 16-d exposure period. The reduction in whole body Na + was short lived and moderate (17%) in the fish exposed to 127 μg/L Cu, but more severe (>30%) and longer lasting in the fish exposed to 202 μg/L Cu. At 289 μg/L Cu, the fish experienced irreversible reductions in whole body Na + and ultimately died. When taken together, results from these two experiments suggest that enhanced tolerance will only develop in fathead minnows that have experienced a pronounced, relatively long-term cycle of branchial damage and repair.

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Relationship between exposure duration, tissue residues, growth, and mortality in rainbow trout (Oncorhynchus mykiss) juveniles sub-chronically exposed to copper

Cited by 61 publications

References 16 publications

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

Cu Accumulation and Elimination in the Tissues of the Olive Flounder Paralichthys olivaceus

Effects of Cu on plasma cortisol and cortisol secretion by adrenocortical cells of rainbow trout (Oncorhynchus mykiss)

Copper acclimation in juvenile fathead minnows: Is a cycle of branchial damage and repair necessary?

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