Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer’s disease

Thientunyakit, Tanyaluck; Thongpraparn, Thonnapong; Sethanandha, Chakmeedaj; Yamada, Takahiro; Kimura, Yuichi; Muangpaisan, Weerasak; Ishii, Kazunari

doi:10.1007/s11604-021-01132-6

Cited by 7 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The middle occipital gyrus is a key brain region in the visual cognitive network, involved in facial recognition and emotional cognition, and plays an important role in visual information integration (Tu et al, 2013). Once damaged, it can lead not only to visual impairment but also to memory deficits and motor perception impairment (Thientunyakit et al, 2021). Therefore, in this study, the abnormal nodal efficiency of the middle occipital gyrus may have played a role in interfering with attention ability.…”

Section: The Important Role Of the Occipital Lobe In The Pathogenesis...mentioning

confidence: 80%

Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder

Geng

Wang

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

PurposeThis study investigates the topological properties of brain functional networks in patients with isolated rapid eye movement sleep behavior disorder (iRBD).Participants and MethodsA total of 21 patients with iRBD (iRBD group) and 22 healthy controls (HCs) were evaluated using resting-state functional MRI (rs-fMRI) and neuropsychological measures in cognitive and motor function. Data from rs-fMRI were analyzed using graph theory, which included small-world properties, network efficiency, network local efficiency, nodal shortest path, node efficiency, and network connectivity, as well as the relationship between behavioral characteristics and altered brain topological features.ResultsRey-Osterrieth complex figure test (ROCFT-copy), symbol digital modalities test (SDMT), auditory verbal learning test (AVLT)-N1, AVLT-N2, AVLT-N3, and AVLT-N1-3 scores were significantly lower in patients with iRBD than in HC (P < 0.05), while trail making test A (TMT-A), TMT-B, and Unified Parkinson’s Disease Rating Scale Part-III (UPDRS-III) scores were higher in patients with iRBD (P < 0.05). Compared with the HCs, patients with iRBD had no difference in the small-world attributes (P > 0.05). However, there was a significant decrease in network global efficiency (P = 0.0052) and network local efficiency (P = 0.0146), while an increase in characteristic path length (P = 0.0071). There was lower nodal efficiency in occipital gyrus and nodal shortest path in frontal, parietal, temporal lobe, and cingulate gyrus. Functional connectivities were decreased between the nodes of occipital with the regions where they had declined nodal shortest path. There was a positive correlation between TMT-A scores and the nodal efficiency of the right middle occipital gyrus (R = 0.602, P = 0.014).ConclusionThese results suggest that abnormal behaviors may be associated with disrupted brain network topology and functional connectivity in patients with iRBD and also provide novel insights to understand pathophysiological mechanisms in iRBD.

show abstract

Section: The Important Role Of the Occipital Lobe In The Pathogenesis...mentioning

confidence: 80%

Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder

Geng

Wang

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Mean cortical SUV ratios (SUVRs) for each subject for both dhPET and wbPET images were calculated using centiloid volumes of interest: voi_CerebGry_2 mm and voi_ctx_2 mm ( http://www.gaain.org/centiloid-project ). For regional SUVR, we used 4 volumes of interest in the major regions specific to Alzheimer disease (frontal, temporal, posterior cingulate, and parietal cortices), which were produced for a previous study ( 14 ). A paired t test was used to compare the mean cortical SUVRs of the 18 F-FDG and 18 F-flutemetamol images between dhPET and wbPET acquisitions.…”

Section: Methodsmentioning

confidence: 99%

High-Resolution Silicon Photomultiplier Time-of-Flight Dedicated Head PET System for Clinical Brain Studies

et al. 2022

Self Cite

View full text Add to dashboard Cite

We acquired brain positron emission tomography (PET) images of fluorodeoxyglucose (FDG) and flutemetamol PET using a time-of-flight-PET system dedicated for the head (dhPET) and a conventional whole-body PET/computed tomography (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. Methods: There were 18 subjects for the FDG-PET study and 17 subjects for the flutemetamol PET study. FDG-PET images were first obtained using wbPET, followed by dhPET. Flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxelwise analysis, and standard uptake value ratio (SUVR). Results: All FDG and flutemetamol images acquired using dhPET were judged as better by visual inspection than those acquired using wbPET. The voxel-wise analysis demonstrated that accumulations in the cerebellum, lateral occipital cortices, and around the central sulcus area in dhPET FDG images were lower than those in wbPET FDG images, whereas accumulations around the ventricle systems were higher in dhPET FDG images than those in wbPET FDG images. Accumulations in the cerebellar dentate nucleus, midbrain, lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET flutemetamol images than those in wbPET flutemetamol images. Mean cortical SUVRs of FDG and flutemetamol dhPET images were significantly higher than those of FDG and flutemetamol wbPET images, respectively. Conclusion: The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.

show abstract

“…Application for Alzheimer's disease AD is an irreversible, progressive brain disease that gradually damages the healthy brain, affecting memory, cognitive abilities, emotions, behavior, and mood. [8][9][10][11][12][13] Impairment of cerebral ISF dynamics in AD was reported in an early paper by Iliff et al 1 Fluorescent-tagged amyloid β (Aβ) was transported along this route, and deletion of the aquaporin-4 (AQP4) gene suppressed the clearance of soluble Aβ, suggesting that this pathway may remove Aβ from the central nervous system. Thus, AD is considered one of the CNS (central nervous system) interstitial fluidopathies.…”

Section: Application Of Dti-alpsmentioning

confidence: 99%

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Taoka,

Ito,

Nakamichi

et al. 2024

MRMS

View full text Add to dashboard Cite

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this moment.The ALPS-index was found to be an indicator of a number of conditions related to the glymphatic system. Thus, although this was expected in the original report, the results of the ALPS method are often interpreted as uniquely corresponding to the function of the glymphatic system. However, a number of subsequent studies have pointed out the problems on the data interpretation. As they rightly point out, a higher ALPS-index indicates predominant Brownian motion of water molecules in the radial direction at the lateral ventricular body level, no more and no less. Fortunately, the term "ALPS-index" has become common and is now known as a common term by many researchers. Therefore, the ALPS-index should simply be expressed as high or low, and whether it reflects a glymphatic system is better to be discussed carefully. In other words, when a decreased ALPS-index is observed, it should be expressed as "decreased ALPS-index" and not directly as "glymphatic dysfunction". Recently, various methods have been proposed to evaluate the glymphatic system. It has become clear that these methods also do not seem to reflect the entirety of the extremely complex glymphatic system. This means that it would be desirable to use various methods in combination to evaluate the glymphatic system in a comprehensive manner.

show abstract

Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer’s disease

Cited by 7 publications

References 37 publications

Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder

Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder

High-Resolution Silicon Photomultiplier Time-of-Flight Dedicated Head PET System for Clinical Brain Studies

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Contact Info

Product

Resources

About