Relationship Between Family Caregiver Burden and Medication Adherence in Patients with Mechanical Valve Replacement: A Structural Equation Model

Abstract

Background: Oral anticoagulant is a necessary long-term treatment after mechanical valve replacement (MVR), and medication adherence has a great impact on patients with MVR. Although family caregiver burden is negatively correlated with medication adherence, little is known about the underlying mechanism. Purpose: To test whether family caregiver burden influences medication adherence through post-traumatic growth or medication literacy in patients with MVR. Patients and Methods: A total of 206 patients after MVR were included in this cross-sectional study from July 2021 to December 2021. Data regarding medication adherence, family caregiver burden, post-traumatic growth, and medication literacy were collected by questionnaires. Data were analyzed through SPSS, and pathway analysis was conducted by using AMOS, based on the bootstrapping method. Results: Post-traumatic growth was positively associated with medication adherence (r = 0.284, P < 0.05). Post-traumatic growth independently mediated the association of family caregiver burden on medication adherence [β = 0.32, 95% confidence intervals: (−0.016, −0.008)]. The mediated effect value for post-traumatic growth was 0.07, accounting for 24.14% of the total effect. The model's fit indices were adequate. Conclusion:The mediating effect of post-traumatic growth between family caregiver burden and medication adherence existed in patients with MVR. Interventions considering post-traumatic growth may be useful to increase medication adherence and improve patient rehabilitation.

Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study

“…Some studies indicated that medication adherence was lower among those with financial difficulties and consideration of the medical expenses as high, which matched those observed in our study ( Liu et al, 2022 ; Drouin et al, 2023 ). Most medications for CPP are the original brands with expensive prices in China, and our study showed that 49.6% of families considered that the medication was expensive and 21.6% of them had difficulty in paying for the medical expenses.…”

“…Our results also found that caregivers in the poor medication adherence group had a worse cognition of the harm of noncompliance with medication, which is in agreement with Zhang et al's findings (Zhang et al, 2022). Caregivers with a lower cognition of medication adherence were more likely to present Some studies indicated that medication adherence was lower among those with financial difficulties and consideration of the medical expenses as high, which matched those observed in our study (Liu et al, 2022;Drouin et al, 2023). Most medications for CPP are the original brands with expensive prices in China, and our study showed that 49.6% of families considered that the medication was expensive and 21.6% of them had difficulty in paying for the medical expenses.…”

Promoting Post-Traumatic Growth in Colorectal Cancer Patients: Exploring the Role of Social Support through a Chain Mediation Model

“…Such factors directly influence the development of PsyCap in CRC patients. In this study, there exists a significant positive association between positive PsyCap and PTG, conforming to the research among medical workers [39] and patients with mechanical valve replacement [40], further confirming the mediating role of positive PsyCap between social support and PTG of CRC patients. Based on these results, it is important for social support to affect PTG by enhancing positive PsyCap in CRC cases.…”

A survey on medication adherence and influencing factors among 226 peritoneal dialysis patients in a primary hospital in China

“…Therefore, the compliance of elderly PD patients in this centre was higher. Indeed, the caregivers' medication adherence level affects the patient's medication taking and treatment effectiveness (Muellers et al, 2019, Liu et al, 2022. However, the medication literacy and adherence levels of caregivers of PD patients are rarely reported and can be explored in future studies.…”