Relationship between fat distribution and cardiometabolic risk in Hispanic girls

Hetherington‐Rauth, Megan; Bea, Jennifer W.; Lee, Vinson R.; Blew, Robert M.; Funk, Janet L.; Lohman, Timothy G.; Going, Scott B.

doi:10.1002/ajhb.23149

Cited by 12 publications

(19 citation statements)

References 49 publications

(62 reference statements)

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“…Interestingly, the relationship between CRP and body composition (total and regional) was generally stronger than previously described for various metabolic biomarkers (i.e., insulin, triglycerides, high‐density lipoprotein, low‐density lipoprotein, glucose) and the same body composition and anthropometric measures used in this cohort . Nevertheless, similar to this analysis, any measure of total or regional adiposity performed equally well for predicting metabolic dysfunction in young Hispanic girls . The relatively higher strength of the correlations between CRP and body composition measures further supports their use in predicting cardiovascular disease risk among Hispanic girls, in addition to common lipid measurements already recommended by the American Academy of Pediatrics before and after puberty (at ages 9‐11 years and 17‐21 years, respectively) .…”

Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 62%

“…Maturation was assessed via chronological age, Tanner stage, and maturity offset. In alignment with prior publication in this cohort , and because of limitations in age and Tanner stage to account for between‐subject variation in maturation , we selected maturity offset for the analyses herein. Maturity offset estimates physical maturity from chronological age and anthropometric measures (height, weight, sitting height, and leg length) using the Mirwald equation .…”

Section: Methodsmentioning

confidence: 99%

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Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Bea

Funk

Hetherington‐Rauth

et al. 2018

Obesity

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Objective To compare total and regional estimates of body composition, by direct and indirect techniques, for the optimal prediction of CRP among young (9–12 year old), Hispanic girls ( N =232). Methods Standard anthropometric techniques were used to measure height, weight, and waist circumference. Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) assessed body composition. Fasting serum CRP was measured by the Beckman Coulter AU5812 Clinical Chemistry Analyzer. Associations between each total and regional body composition parameter and CRP were tested using linear regression (log-transformed, continuous CRP) and ordinal logistic regression (CRP < 1.0, ≥1.0–2.9, and ≥ 3.0 mg/L), controlling for maturation, dietary energy, physical activity, and medications. Results All measures of total and regional body fat were positively associated with CRP (P<0.0001), except for intermuscular fat by pQCT. There were no clinically relevant differences in their association with CRP between anthropometric (BMI; waist circumference) and DXA-derived (total fat and regional fat: trunk, gynoid, android fat, leg) measures of fat. Conclusions Measurement of body habitus in Hispanic girls, by multiple commonly available means, predicts CRP equally well.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

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Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Bea

Funk

Hetherington‐Rauth

et al. 2018

Obesity

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“…Another US study on 421 adolescents reported that greater abdominal obesity was associated with increased risk of metabolic syndrome (24). Conversely, Hetherington-Rauth et al showed that among 232 Hispanic girls aged 9 to 12 years, TBF% and regional adiposity were similarly associated with cardiometabolic risk factors (25), although the authors did not include A/G among the parameters assessed.…”

Section: Discussionmentioning

confidence: 98%

“…Several studies have shown an association between A/G and the risk of cardiometabolic disease in adults (20)(21)(22). However, a limited number of studies have focused on children and adolescents (23)(24)(25)(26)(27), with paucity of data on the influence of pubertal development. Further, the reported associations between cardiometabolic risk and total vs. abdominal adiposity is inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Children and Adolescents With Obesity

Jin

Yuan

et al. 2020

Front. Endocrinol.

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Objective: We aimed to assess the role of adipose tissue distribution in cardiometabolic risk (in particular insulin sensitivity) in a population of children and adolescents with obesity. Methods: In this cross-sectional study, participants were 479 children and adolescents with obesity (322 boys and 157 girls) aged 3 to 18 years attending the Children's Hospital at Zhejiang University School of Medicine (Hangzhou, China). Clinical assessments included anthropometry, body composition (DXA scans), carotid artery ultrasounds, and OGTT. Insulin sensitivity was assessed using the Matsuda index. Participants were stratified into groups by sex and pubertal stage. Key predictors were DXA-derived android-to-gynoid-fat ratio (A/G) and total body fat percentage (TBF%). Results: Irrespective of sex and pubertal stage, there was a strong association between increasing A/G (i.e., greater abdominal adiposity) and lower insulin sensitivity. In multivariable models, every 0.1 increase in A/G was associated with a reduction in insulin sensitivity in prepubertal boys [−29% (95% CI −36%, −20%); p < 0.0001], pubertal boys [−13% (95% CI −21%, −6%); p = 0.001], and pubertal girls [−16% (95% CI −24%, −6%); p = 0.002]. In contrast, TBF% was not associated with insulin sensitivity when A/G was adjusted for, irrespective of pubertal stage or sex. In addition, every 0.1 increase in A/G was associated with increased likelihood of dyslipidemia in prepubertal boys [adjusted odds ratio (aOR) 1.62 (95% CI 1.05, 2.49)], impaired glucose tolerance in pubertal boys [aOR 1.64 (95% CI 1.07, 2.51)] and pubertal girls [aOR 1.81 (95% CI 1.10, 2.98)], and odds of NAFLD in both prepubertal [aOR 2.57 (95% CI 1.56, 4.21)] and pubertal [aOR 1.69 (95% CI 1.18, 2.40)] boys. In contrast, higher TBF% was only associated with higher fasting insulin and ALT in pubertal boys, being also predictive of NAFLD in this group Jin et al. A/G and Body Fat% as Cardiometabolic Predictors [aOR 1.15 per percentage point (95% CI 1.06, 1.26)], but was not associated with the likelihood of other cardiometabolic outcomes assessed in any group. Conclusions: A/G is a much stronger independent predictor of cardiometabolic risk factors in children and adolescents with obesity in China, particularly glucose metabolism.

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The Abnormal Ratio of Android-Gynoid Fat, Measured by Dual-Energy X-Ray Absorptiometry (DEXA) Scans, is Moderately Useful for Diagnosing Metabolic Syndrome in Children and Adolescents

Martino

Albanese

et al. 2023

Journal of Clinical Densitometry

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Relationship between fat distribution and cardiometabolic risk in Hispanic girls

Abstract: Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.

Cited by 12 publications

References 49 publications

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Children and Adolescents With Obesity

The Abnormal Ratio of Android-Gynoid Fat, Measured by Dual-Energy X-Ray Absorptiometry (DEXA) Scans, is Moderately Useful for Diagnosing Metabolic Syndrome in Children and Adolescents

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