Relationship Between Fatty Degeneration of Thigh Muscles and Vitamin D Status in the Elderly: A Preliminary MRI Study

Tagliafico, Alberto; Ameri, Pietro; Bovio, Marta; Puntoni, Matteo; Capaccio, Enrico; Murialdo, Giovanni; Martinoli, Carlo

doi:10.2214/ajr.09.3130

Cited by 49 publications

(40 citation statements)

References 27 publications

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“…21 In addition, two studies reported an association between low 25(OH)D levels and fatty degeneration of thigh and rotator cuff muscles. 23,24 This potential effect of vitamin D on muscle biology is likely to affect creatinine production. Indeed, an increase in creatininemia due to enhanced creatinine production without variation in GFR has been reported under calcitriol therapy.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

100

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Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between January 2005 and June 2010. In this cohort, low 25-hydroxyvitamin D concentrations 3 months after transplantation did not predict early death or graft loss but were independently associated with lower measured GFR at 12 months (P=0.001) and higher risk for interstitial fibrosis and tubular atrophy (P=0.01). In contrast, levels of calcium, phosphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associated with any of the studied outcomes. In conclusion, low 25-hydroxyvitamin D concentration measured 3 months after transplantation is an independent risk factor for interstitial fibrosis progression and is associated with a lower GFR 1 year after transplantation. 24: 831-841, 201324: 831-841, . doi: 10.1681 Kidney transplantation is the preferred treatment for the increasing number of patients with ESRD. Transplantation allows patients to avoid the heavy constraints associated with dialysis therapy and is associated with a lower mortality and morbidity than is hemodialysis. 1 Evolution of GFR in transplant recipients appears to be imprinted at an early stage after the surgery. Indeed, the estimated GFR (eGFR) reached 1 year after transplantation is critically associated with allograft outcome. 2,3 This observation prompts research on modifiable factors affecting GFR in the first year after transplantation. J Am Soc NephrolVitamin D is a critical hormone controlling mineral homeostasis. It promotes phosphate and calcium absorption by the gut and increases calcium reabsorption by the renal distal tubule, thereby providing the positive calcium and phosphorus flux required for bone mineralization.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

100

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“…Biopsy and imaging findings consistent with muscular atrophy have been associated with 25-OH vitamin D deficiency [34,35]. Furthermore, supplementation with calcium and vitamin D improves the number and size of muscle fibers [13] as well as lower extremity function [36].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency, self-reported physical activity and health-related quality of life: the Comprehensive Dialysis Study

Anand¹,

Kaysen²,

Chertow³

et al. 2011

Nephrology Dialysis Transplantation

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Background. As research has identified a wide array of biological functions of vitamin D, the consequences of vitamin D deficiency in persons with chronic kidney disease has attracted increased attention. The objective of this study was to determine the extent of 25-hydroxyvitamin D (25-OH vitamin D) deficiency and its associations with self-reported physical activity and health-related quality of life (HRQoL) among participants of the Comprehensive Dialysis Study (CDS). Methods. The nutrition substudy of the CDS enrolled patients new to dialysis from 68 dialysis units throughout the USA. Baseline 25-OH vitamin D concentration was measured using the Direct Enzyme Immunoassay (Immunodiagnostic Systems Inc.). Physical activity was measured with the Human Activity Profile (HAP); the Medical Outcomes Study Short Form-12 (SF-12) was employed to measure HRQoL. Results. Mean age of the participants (n ¼ 192) was 62 years. There were 124 participants (65%) with 25-OH vitamin D concentrations < 15 ng/mL, indicating deficiency, and 64 (33%) with 25-OH vitamin D! 15 to <30 ng/mL, indicating insufficiency. After adjusting for age, sex, race/ ethnicity, diabetes, season and center, lower 25-OH vitamin D concentrations were independently associated with lower scores on the HAP and on the Mental Component Summary of the SF-12 (P < 0.05 for both), but not with the Physical Component Summary of the SF-12. Conclusion. In a well-characterized cohort of incident dialysis patients, lower 25-OH vitamin D concentrations were associated with lower self-reported physical activity and poorer self-reported mental health.

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“…Subjects with mutations of the VDR or severe vitamin D deficiency show generalized muscle atrophy, even before biochemical signs of bone disease appear 36, 47. Changes in muscle morphology include derangement of the intermyofibrillar network, increases in intramuscular lipids, and atrophy of the fast‐twitch white (type 2) fibres,11, 44, 48, 49 which are the first to be recruited when preventing a fall. All these changes seem to be reversible,50 supporting co‐ordinated effects of vitamin D in musculoskeletal physiology 51, 52, 53, 54…”

Section: Vitamin D Physiologymentioning

confidence: 99%

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Molina

Carrero

Bover

et al. 2017

J cachexia sarcopenia muscle

102

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The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.

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Relationship Between Fatty Degeneration of Thigh Muscles and Vitamin D Status in the Elderly: A Preliminary MRI Study

Abstract: In elderly adults, fatty degeneration of thigh muscles was associated with vitamin D deficiency and impaired balance and gait. Selective complete fatty degeneration of single muscles was observed.

Cited by 49 publications

References 27 publications

Vitamin D Status and Outcomes After Renal Transplantation

Vitamin D Status and Outcomes After Renal Transplantation

Vitamin D deficiency, self-reported physical activity and health-related quality of life: the Comprehensive Dialysis Study

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

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